Serum vascular adhesion protein-1 predicts 10-year cardiovascular and cancer mortality in individuals with type 2 diabetes.

Abstract

OBJECTIVE:

Vascular adhesion protein-1 (VAP-1) participates in inflammation and catalyzes the breakdown of amines to produce aldehyde, hydrogen peroxide, and ammonia. Serum VAP-1 correlates positively with both acute hyperglycemia and diabetes. We conducted a cohort study to evaluate whether serum VAP-1 predicts 10-year survival in type 2 diabetic patients.

RESEARCH DESIGN AND METHODS:

Between July 1996 and June 2003, we enrolled 661 type 2 diabetic subjects at National Taiwan University Hospital. Serum VAP-1 in the samples obtained at enrollment was measured by time-resolved immunofluorometric assay. The vital status of all subjects was ascertained by linking their data with computerized death certificates in Taiwan.

RESULTS:

The medium follow-up period was 10.4 years. Subjects with serum VAP-1 in the highest tertile had a hazard ratio (HR) of 2.19 (95% CI 1.17-4.11) for all-cause mortality adjusted for age, sex, smoking, history of cardiovascular disease, obesity, hypertension, hemoglobin A(1c), diabetes duration, total cholesterol, use of statins, abnormal ankle-brachial index, estimated glomerular filtration rate (eGFR), and proteinuria. The adjusted HRs for logarithmically transformed serum VAP-1 were 5.83 (95% CI 1.17-28.97) for cardiovascular mortality, 6.32 (95% CI 1.25-32.00) for mortality from cardiovascular and diabetic causes, and 17.24 (95% CI 4.57-65.07) for cancer mortality. There were four variables, including age, serum VAP-1, proteinuria, and eGFR, which could enhance mortality prediction significantly.

CONCLUSIONS:

Serum VAP-1 can predict 10-year all-cause mortality, cardiovascular mortality, and cancer mortality independently in type 2 diabetic subjects. Serum VAP-1 is a novel biomarker that improves risk prediction over and above established risk factors.

• Authors: Hung-Yuan Li, Yi-Der Jiang, Tien-Jyun Chang, Jung-Nan Wei, Mao-Shin Lin, Cheng-Hsin Lin, Fu-Tien Chiang, Shyang-Rong Shih, Chi Sheng Hung, Cyue-Huei Hua, David J Smith, Jani Vanio, Lee-Ming Chuang
• Journal: Diabetes (Diabetes) Vol. 60 Issue 3 Pg. 993-9 (Mar 2011) ISSN: 1939-327X [Electronic] United States
• PMID: 21282368 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cell Adhesion Molecules
• AOC3 protein, human
• Amine Oxidase (Copper-Containing)

Topics

• Aged
• Amine Oxidase (Copper-Containing) (blood)
• Analysis of Variance
• Cardiovascular Diseases (blood, mortality)
• Cell Adhesion Molecules (blood)
• Chi-Square Distribution
• Diabetes Mellitus, Type 2 (blood, mortality)
• Female
• Humans
• Male
• Middle Aged
• Neoplasms (blood, mortality)
• Predictive Value of Tests
• Prospective Studies
• Risk Factors
• Taiwan (epidemiology)