Proteinuria

1.	Nephrotic Syndrome (Syndrome, Nephrotic)
2.	Hypertension (High Blood Pressure)
3.	Glomerulonephritis
4.	Hematuria
5.	IGA Glomerulonephritis (IGA Nephropathy)

Experts

1.	Arias, M: 7 articles (09/2007 - 11/2001)
2.	Campistol, Josep M: 6 articles (08/2008 - 02/2006)
3.	Diekmann, Fritz: 5 articles (02/2008 - 02/2006)
4.	Ruiz, J C: 5 articles (09/2007 - 02/2002)
5.	Kawachi, Hiroshi: 5 articles (09/2005 - 04/2002)
6.	Shimizu, Fujio: 5 articles (09/2005 - 04/2002)
7.	Saruta, Takao: 4 articles (02/2006 - 02/2003)
8.	van Goor, Harry: 4 articles (01/2006 - 02/2003)
9.	Petrović, Dejan: 4 articles (12/2005 - 03/2002)
10.	Stojimirović, Biljana: 4 articles (12/2005 - 03/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Proteinuria:

1.	CreatinineIBA 07/01/2009 - "METHODS: Patients with biopsy-proven MN, nephrotic-range proteinuria and clearance of creatinine 50 ml/min or more were included in the study. " 07/01/1994 - "PATIENTS: The study subjects comprised 13 patients with biopsy-proven renal disease, a diastolic blood pressure of > 90 mmHg, creatinine clearance of > 60 ml/min and stable proteinuria of > 2.0 g/day. " 05/01/2009 - "G1 patients showed a marked decrease in proteinuria and stabilized serum creatinine with time. " 05/01/2007 - "Patients with severe proteinuria, those with advanced tubulointerstitial changes at renal biopsy and those with increased serum creatinine at presentation have a poorer prognosis, while patients showing complete or even partial remission of proteinuria have a favorable prognosis. " 06/01/2006 - "Renal function, which had been deteriorating before treatment, improved as evidenced by the stabilization of serum creatinine and marked improvement of proteinuria. " Order ALL the reference details at left...
2.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 04/01/1992 - "Patients with recurrent FGS who were treated with ACE inhibitors benefited from a significant reduction of proteinuria. " 01/01/2008 - "Reduction in proteinuria from ARBs and ACE inhibitors is similar, but their combination is more effective than either drug alone. " 05/22/1995 - "RESULTS: In 14 randomized controlled trials, angiotensin-converting enzyme inhibitors caused a greater decrease in proteinuria (pooled mean [95% confidence intervals], -0.51[-0.68 to -0.35], ln [treatment/control]), improvement in glomerular filtration rate (0.13 mL/min per month [0.10 to 0.16 mL/min per month]), and decline in mean arterial pressure (-4.0 mm Hg [-4.9 to -3.0 mm Hg]) compared with controls. " 09/01/2007 - "As it has been demonstrated that angiotensin-converting enzyme inhibitors (ACEi) have a renoprotective effect in adults with proteinuric disease and may be effective in reducing hyperfiltration and proteinuria, they are also frequently used as anti-progression agents in paediatric patients with CKD despite the lack of data confirming their role in the nephropathies peculiar to children. " 03/01/2007 - "ACE inhibitors are effective in controlling proteinuria in patients with microalbuminuria y proteinuria. " Order ALL the reference details at left...
3.	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/01/1996 - "In the third patient, proteinuria relapsed after 9 months of complete remission and persisted in spite of the reintroduction of intravenous cyclosporin. " 03/01/1988 - "Cyclosporine A was started at 7 mg/kg/day and titrated to maintain HPLC level of 100 to 200 ng/ml. Of 20 patients, 14 had a complete remission and the remaining 6 had a reduction in their proteinuria. " 12/01/1987 - "Cyclosporine was started at 7 mg/kg/d and titrated to maintain a serum level of 100 to 200 ng/mL. Of 20 patients, 14 had a complete remission and the remaining six had a reduction in their proteinuria. " 06/01/1989 - "In the three patients who achieved complete remission, relapse of proteinuria occurred within six weeks of ceasing Cyclosporin. " 02/01/1998 - "Our study implies that Neoral appears to be effective in suppressing proteinuria. " Order ALL the reference details at left...
4.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 03/01/1979 - "Full remission in 2 patients in each of the two groups treated with drugs, and diminution of proteinuria in most patients in the cyclophosphamide group showed possible evidence of benefit. " 11/01/2003 - "Recently, intravenous cyclophosphamide (IV-CPM) infusion was shown to be effective, safe, and economical for the treatment of SRNS, particularly minimal change disease (MCD), as it results in more sustained remissions, longer periods without proteinuria, and fewer significant side effects at a lower cumulative dose. " 08/01/2007 - "CONCLUSIONS: A 12-month course of MMF decreased proteinuria and improved renal function in the majority of patients, but did not appear as effective or better tolerated than cyclophosphamide. " 08/01/2007 - "Cumulative incidences of remission of proteinuria at 12 months were 66% in the MMF group versus 72% in the cyclophosphamide group (P = 0.3). " 07/01/2002 - "After the 4th pulse of cyclophosphamide the proteinuria was negative, and the patient remains in clinical and laboratorial remission since the end of the 6 pulses, and after 14 months of follow-up." Order ALL the reference details at left...
5.	Prednisolone (Predate)FDA LinkGeneric 05/01/2003 - "RESULTS: Of the 60 patients, 20 cases (33.3%) (Group 1) reached a complete remission of proteinuria by prednisolone alone. " 08/01/1989 - "Clinically, those patients were divided into four stages as follows: (1) untreated nephrotic stage, (2) prednisolone (PSL) treated nephrotic stage, (3) persistent proteinuria stage (incomplete remission, ICR), and (4) complete remission (CR). " 04/03/1987 - "In the 4 cases with complete remission of proteinuria prednisolone was tapered. " 01/01/2006 - "Maximal proteinuria, total amount of BCL, BCL exposure time, and use of prednisolone or other immunosuppressant agents did not significantly influence time until remission. " 01/01/2005 - "Although she had received prednisolone at an initial dose of 45 mg/day, no significant improvement of proteinuria was achieved. " Order ALL the reference details at left...
6.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 11/01/2009 - "Proteinuria resolved completely following the initiation of a gluten-free diet, without the use of immunosuppressive therapy and despite tapering of angiotensin-converting enzyme inhibitor. " 04/27/1992 - "We have previously reported that angiotensin-converting enzyme (ACE) inhibition in Munich Wistar Fromter/Ztm (MWF/Ztm) rats resulted in a significant reduction of proteinuria, in respect to untreated animals, and that treated animals were protected against the development of glomerular sclerotic lesions. " 07/01/2003 - "Remission of nephrotic range proteinuria has also been reported in some patients with type 1 diabetes from the Collaborative Study Group during a median follow-up of 3 years of angiotensin-converting enzyme (ACE) inhibitor administration; no deterioration of renal function was observed in these patients. " 04/01/2005 - "[Influence of angiotensin-converting enzyme gene polymorphism on the anti-proteinuria efficacy of angiotensin-converting enzyme inhibitor in Han nationality of southern Sichuan province in China]" 07/01/2007 - "The maximum mean percent reduction was attained at 3 months (47% +/- 27%), was not influenced by the levels of baseline proteinuria, and was similar in patients receiving or not receiving angiotensin-converting enzyme inhibition at the start of the study. " Order ALL the reference details at left...
7.	Serum AlbuminIBA 09/01/2008 - "RESULTS: (1) Complete remission (proteinuria < or = 0.1 g/d or negative by dipstick for 3 consecutive days), partial remission (proteinuria between 0.1 g/d and 50 mg/(kg.d), serum albumin > or = 30 g/L) and resistance to CsA (proteinuria > or = 50 mg/(kg.d), or > or = 3+ by dipstick, after 6 months of CsA treatment over a trough level of 100 microg/L) were observed in 65%, 20% and 15%, respectively. " 04/01/2003 - "At the end of 6 months treatment, 7 (29.2%) patients each had complete remission (absent proteinuria, normal serum albumin) and partial remission (1-2+ proteinuria, normal serum albumin). " 08/01/1998 - "A significant reduction of proteinuria and a significant rise in serum albumin were noted 1 month after initiation of treatment. " 09/01/2000 - "We will consider satisfactory remission the reduction of proteinuria below 1 g/day, improvement of renal function, normalization of serum albumin level (> 3.5 g/dl). " 09/01/2000 - "Partial remission will be considered: proteinuria below 3 g/day, stable renal function, serum albumin level between 3 and 3.5 g/dl. " Order ALL the reference details at left...
8.	SteroidsIBA 01/01/2006 - "Steroids seem to be the best treatment for patients with proteinuria, as drugs in this class ameliorate this symptom and protect against deterioration of renal function. " 05/01/1987 - "Eighteen patients were treated with steroids; ten of these had complete remission of proteinuria and seven a significant reduction of their proteinuria. " 01/01/2008 - "The treatment with steroids was the only factor that forecasted a high renal survival (hazard ratio or HR: 0.07, 0.01-0.9) and proteinuria remission (HR: 0.2, 0.04-0.9). " 01/01/2004 - "Cox multivariate regression analyses showed that, in addition to steroids, a low baseline histologic score, a reduction in proteinuria after 6 mo, and no increase in proteinuria during follow-up all were independent predictors of a beneficial outcome. " 02/01/1996 - "Patients who received higher total dosage of steroids and CsA had significantly greater proteinuria. " Order ALL the reference details at left...
9.	Losartan (Cozaar)FDA Link 07/01/2004 - "In case 2, losartan with steroid and immunosuppressant led to the complete remission of proteinuria, improvement of renal dysfunction and reduction of the glomerular injury score from repeat biopsy specimen by approximately 20%. " 01/01/2004 - "Proteinuria reduction was significantly greater in patients receiving combined therapy in comparison with losartan treatment after 3 months of therapy (p = 0.02). " 03/01/2005 - "HYPOTHESIS: This post hoc analysis examined whether baseline proteinuria was predictive of cardiovascular outcomes, and whether losartan modifies the risk of cardiovascular outcomes in these patients given its renal-protective effects. " 04/01/2009 - "RESULTS: Short-term losartan treatment, besides antihypertensive effect, improved glomerular filtration rate and ameliorated glomerulosclerosis resulting in decreased proteinuria. " 09/01/2008 - "The investigators found that patients with type 2 diabetes and proteinuria who have the D allele have an unfavorable renal prognosis, which is improved by losartan treatment (vs placebo) when given together with conventional antihypertensive treatment. " Order ALL the reference details at left...
10.	Immunoglobulin G (IgG)IBA 07/01/1991 - "Glomerular permselective dysfunction (proteinuria) was measured as the fractional clearance of albumin (fractional clearance of albumin) and of IgG. Stepwise multiple regression analysis revealed the percentage of the glomerular basement membrane occupied by dense deposits, slit number/glomerular basement membrane, and glomerular basement membrane thickness statistically explained most (81%) of the variation in fractional clearance of albumin and IgG. These results suggest that epithelial slit length is the most important structural determinant of GFR and that the increase in MGV maintains filtration surface area despite evidence of an extensive inflammatory insult. " 07/01/2008 - "Compared with control mice, IL-18R-deficient mice showed a significant reduction of proteinuria, renal pathological findings including glomerular IgG and C3 deposits, and leukocyte infiltrates. " 09/01/2009 - "Treatment of NZB/W mice with the beta-galactosylceramide ameliorated lupus disease activity as judged by improvement in proteinuria, renal histopathology, IgG anti-dsDNA antibody formation, and survival. " 02/01/2006 - "Neither absolute levels of urinary IgG, beta(2)M or alpha(1)M at baseline or at 12 months nor the percentage reduction between baseline and 12 months clearly predicted the occurrence of a remission or a relapse to nephrotic range proteinuria. " 09/01/1988 - "A corresponding increase in fractional clearance of anionic (pI 4.5-5.0) over neutral (pI 7.0-7.5) IgG species was observed in patients with subnephrotic-range proteinuria. " Order ALL the reference details at left...

Therapies and Procedures

1.	Transplants (Transplant) 01/01/2000 - "A significant reduction in proteinuria without adversely affecting graft function was the main beneficial effect observed. " 07/01/2008 - "In addition, the continuous improvement in pancreas transplant alone, offering the opportunity to reduce cardiovascular risk due to proteinuria and reduced glomerular filtration rate (GFR), is rarely appreciated. " 10/01/2002 - "After remission of the NS, the grafts functioned well without or with minimal proteinuria for several years. " 05/27/1999 - "Renal function and proteinuria spontaneously improved, and a second transplant biopsy performed 8 months after the first one revealed fibrotic organization of half of the glomeruli and of interstitial tissue, and crystal vanishing. " 12/15/1996 - "All treatment regimens decreased the systemic and glomerular capillary pressures and were associated with no loss of function, decreased proteinuria, and a tendency to improved graft function. " Order ALL the reference details at left...
2.	Aftercare (After-Treatment) 07/01/2003 - "Proteinuria and haematuria improved after treatment. " 11/01/2001 - "The study was stopped prematurely after treatment of the first 24 subjects due to proteinuria in five of the 16 subjects who received systemic bFGF, which exceeded 1000 mg/24 h in four of these five subjects. " 01/15/1993 - "STUDY SELECTION: We selected 100 controlled and uncontrolled studies that provided data on renal function, proteinuria, or both, before and after treatment with an antihypertensive agent. " 11/01/2009 - "Data provide support, however, for reducing proteinuria by at least 30% after treatment is initiated in patients with proteinuria. " 10/01/2009 - "Both proteinuria and M-protein disappeared completely, and he is doing well clinically at 19 months after treatment. " Order ALL the reference details at left...
3.	Drug Therapy (Chemotherapy) 06/01/2005 - "Improvement in renal function and proteinuria following VAMP chemotherapy correlated with a reduction in circulating light-chain levels. " 01/01/2003 - "Following the serial chemotherapy his proteinuria improved, and M protein became undetectable in both serum and urine. " 01/01/1989 - "The difference between groups 1 and 2 is not simply due to differences in response to chemotherapy, for many group-1 patients achieve improvement in renal function without or before loss of light chain proteinuria. " 05/01/1999 - "Proteinuria rapidly diminished during chemotherapy. " 01/22/1999 - "Both CZE methods were linear between 2.5 and 50 microg/ml, exhibited satisfactory precision (relative standard deviation <10%) and were suitable for monitor the time course of proteinuria after chemotherapy administration. " Order ALL the reference details at left...
4.	Transplantation (Transplant Recipients) 02/01/2003 - "High P(alb) is associated with recurrence of FSGS after transplantation, but serial studies of P(alb) activity in patients with native kidney FSGS have not been performed, and the relationship between P(alb) and remission of proteinuria is not known. " 01/01/2007 - "Eighteen months after transplantation the patient keeps haematological remission and normal renal function, without proteinuria.Since" 12/01/2008 - "OBJECTIVE: To study the effect of multiglycosides of Tripterygium wilfordii (MTW) for treatment of proteinuria in kidney transplant recipients. " 04/01/2008 - "Because proteinuria is a major predictive factor of poor transplantation outcome, many studies focused on this adverse event during the past years. " 11/01/2007 - "Aim of the study was to find out the impact of successful SKPT on proteinuria and further functioning of the patient's own kidneys after transplantation. " Order ALL the reference details at left...
5.	Plasma Exchange 03/01/2004 - "Plasma exchange (PE) can reduce proteinuria and even induce complete remission of proteinuria. " 11/01/1999 - "Treatment with plasma exchange can lead to complete remission of proteinuria and relapsing patients may respond to repeated sessions. " 11/01/2006 - "To treat recurrent FSGS, plasma exchange was partially effective to reduce proteinuria. " 09/01/2004 - "To treat recurrent FGS, plasma exchange was partially effective, reducing the proteinuria but not stopping the progression of disease. " 01/01/1986 - "In 5 patients renal function and/or proteinuria improved after plasma exchange, and no clinical relapse usually occurred when the procedures were reduced or discontinued. " Order ALL the reference details at left...

Best Treatments:
Research Summary Report
on Proteinuria

CureHunter Patient-Physician Summary Reports collect in one document all the medications ever reported in the US National Library of Medicine—1949 to the present—to be effective against your target disease. CureHunter research summary reports will vary in length from 25 to 250 pages. Analytic charts allow you and your physicians to see at a glance your medication options—including new, promising, off-label and experimental all rated for clinical efficacy.

Free Updates for 1 Year
All 965 Outcomes
Top 200 Key Drugs and Biologics
Top 50 Key Therapies and Procedures
Detailed History Charts
Full Research Reference Details
Sample PDF Report on Psoriasis >>

Price:

$24.00 & Delivery via PDF download
updates for 1 year

Research Interface

Rapidly retrieve summaries of all the evidence for any disease in seconds. Save hours of search and analysis time. CureHunter is unlike any "search engine" you have ever used. Where standard "search engines" produce lists of links, CureHunter quantifies evidence, extracts it from the literature and calculates a result you can use to immediately facilitate evidence based decision making in Real Clinical Time.

Unlimited Disease, Drug and Therapy Search
2 clicks from Disease to Drug to Evidence
Trial References
All the Positive Outcomes
Detailed Relationship Timeline Charts
Full Article Reference Details
Includes Mobile Interface Subscription
One-click to FDA Products/Patents
Request Institution License Details >>

Price:

$490.00 access via web interface
1 year subscription

Proceed to Checkout >>

Mobile Interface

Retrieve summaries of all the evidence for any disease from your Mobile Phone or PDA. Accelerate decision making in the field. Speed up your study of new drug and disease domains. Refresh your knowledge on the road.

Access from any web enabled PDA or Phone
Trial references
All the Positive Outcomes
Drug and Therapy searches
Full Article Reference Details
Try Mobile Interface >>

Price:

$45.00 access via "curehunter.com/m"
1 year subscription

Proceed to Checkout >>