The cardiopulmonary continuum systemic inflammation as 'common soil' of heart and lung disease.

Abstract

Coronary artery disease (CAD), chronic heart failure (CHF) or chronic obstructive pulmonary disease (COPD) occur commonly in the presence of each other and are associated with similar systemic inflammatory reactions. Inflammation plays a central role in the pathogenesis of these diseases. C-reactive protein (CRP) could represent the sentinel biomarker to all chronic diseases. Also, interleukin (IL)-6 may play a causal role in systemic inflammatory diseases. These complex interactions between heart and lung can be denoted as 'cardiopulmonary continuum'. Common risk factors induce systemic inflammatory processes which lead to progression of atherosclerotic diseases as well as COPD.

• Authors: Christian Ukena, Felix Mahfoud, Michael Kindermann, Ingrid Kindermann, Robert Bals, Adriaan A Voors, Dirk J van Veldhuisen, Michael Böhm
• Journal: International journal of cardiology (Int J Cardiol) Vol. 145 Issue 2 Pg. 172-176 (Nov 19 2010) ISSN: 1874-1754 [Electronic] Netherlands
• PMID: 20570377 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

Topics

• Animals
• Coronary Artery Disease (complications, pathology)
• Heart Failure (complications, pathology)
• Humans
• Inflammation (complications, pathology)
• Pulmonary Disease, Chronic Obstructive (complications, pathology)
• Systemic Inflammatory Response Syndrome (complications, pathology)