Abstract | PURPOSE: The cancer cell microenvironment includes complex interactions between the cell and the extracellular matrix. Expression of the CCN family of extracellular matrix associated proteins is often modified in disease states. Depending on cancer type these changes are linked with enhanced or inhibited tumor growth. We characterized Cyr61 in prostate cancer. Cyr61 is an integrin binding matricellular protein with altered expression in many cancer types. MATERIALS AND METHODS: RESULTS: On genomic analysis Cyr61 up-regulation was observed in prostate cancer tissue and in normal prostate tissue adjacent to tumor vs that in prostate donor tissue. In 174 matched tumors and normal prostate tissues adjacent to tumor tissue microarray revealed significantly up-regulated Cyr61 protein expression in cancer tissue vs normal prostate tissue adjacent to tumor. Also, increased Cyr61 expression correlated with Gleason sum 8 or greater cancer. Staining in high grade prostatic intraepithelial neoplasia was moderately up-regulated vs that in normal prostate tissue adjacent to tumor but generally less intense than in carcinoma tissue. CONCLUSIONS: In addition to the correlation with more advanced disease, the strong association between Cyr61 expression and prostate cancer supports the potential usefulness of Cyr61 as a novel biomarker for prostate cancer. This warrants further analysis to determine the mechanisms by which Cyr61 may contribute to prostate cancer development and progression.
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Authors | Katherine B D'Antonio, Antoun Toubaji, Roula Albadine, Alison M Mondul, Elizabeth A Platz, George J Netto, Robert H Getzenberg |
Journal | The Journal of urology
(J Urol)
Vol. 183
Issue 4
Pg. 1604-10
(Apr 2010)
ISSN: 1527-3792 [Electronic] United States |
PMID | 20172544
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright (c) 2010 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- CCN1 protein, human
- Cysteine-Rich Protein 61
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Topics |
- Adult
- Aged
- Cysteine-Rich Protein 61
(analysis, biosynthesis, physiology)
- Humans
- Male
- Microarray Analysis
- Middle Aged
- Prostatic Neoplasms
(chemistry, etiology)
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