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Prostatic Intraepithelial Neoplasia

Subscribe to Selected New Research on Prostatic Intraepithelial Neoplasia
415  relevant articles (6 outcomes, 65 trials/studies) found for this Disease

Description: A premalignant change arising in the prostatic epithelium, regarded as the most important and most likely precursor of prostatic adenocarcinoma. The neoplasia takes the form of an intra-acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia, which corresponds to nuclear grade 2 and 3 invasive prostate cancer.

Also Known As:
Intraepithelial Prostatic Neoplasia; Prostatic Intraepithelial Neoplasms; Intraepithelial Neoplasia, Prostatic; Intraepithelial Neoplasm, Prostatic; Intraepithelial Neoplasms, Prostatic; Intraepithelial Prostatic Neoplasias; Neoplasia, Intraepithelial Prostatic; Neoplasm, Prostatic Intraepithelial; Neoplasms, Prostatic Intraepithelial; Prostatic Intraepithelial Neoplasias; Prostatic Intraepithelial Neoplasm; Prostatic Neoplasia, Intraepithelial; Neoplasia, Prostatic Intraepithelial

Relationship Network

Disease Context: Research Results

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Neoplasms: 387730
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Neoplasms by Histologic Type: 1
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Glandular and Epithelial Neoplasms: 238
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Carcinoma: 89436
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Carcinoma in Situ: 1444
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Prostatic Intraepithelial Neoplasia: 415

Related Diseases

1. Prostatic Neoplasms (Prostate Cancer)
2. Neoplasms (Cancer)
3. Adenocarcinoma
4. Prostatic Hyperplasia (Benign Prostatic Hyperplasia)
5. Carcinoma (Carcinomatosis)

Experts

1. Bostwick, David G: 6 articles (09/2007 - 01/2003)
2. Cheng, Liang: 5 articles (12/2007 - 02/2002)
3. Montironi, Rodolfo: 4 articles (12/2007 - 08/2004)
4. Eble, John N: 4 articles (02/2004 - 02/2002)
5. Zhang, Shaobo: 4 articles (02/2004 - 02/2002)
6. Koch, Michael O: 4 articles (02/2004 - 02/2002)
7. Mazzucchelli, Roberta: 3 articles (12/2007 - 08/2004)
8. Yang, Ximing J: 3 articles (06/2005 - 09/2002)
9. Cardiff, Robert D: 3 articles (06/2004 - 08/2002)
10. Ulbright, Thomas M: 3 articles (02/2004 - 07/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Prostatic Intraepithelial Neoplasia:
1. Prostate-Specific Antigen (Semenogelase)IBA
2. Finasteride (Propecia)FDA LinkGeneric
3. Toremifene (Fareston)FDA Link
4. MucinsIBA
01/01/2007 - "Minor criteria include intraluminal wispy blue mucin, pink amorphous secretions, mitotic figures, intraluminal crystalloids, adjacent high-grade prostatic intraepithelial neoplasia, amphophilic cytoplasm and nuclear hyperchromasia"
08/01/2000 - "Other features associated with malignancy (mitoses, blue-tinged mucin, adjacent high-grade prostatic intraepithelial neoplasia, and perineural invasion) were seen infrequently"
12/01/1997 - "The following histologic features were identified in 54 cases: enlarged nucleoli, 54 (100%); enlarged nuclei, 45 (83%); intraluminal eosinophilic secretions, 40 (74%); infiltrative growth, 37 (68%); small acinar proliferation, 37 (68%); intraluminal basophilic mucin, 23 (42%); amphophilic cytoplasm, 18 (33%); high-grade prostatic intraepithelial neoplasia, 17 (31%); and crystalloids, 12 (22%)"
10/01/1999 - "Histologic features that were helpful in the diagnosis of cancer after radiation therapy included infiltrative growth, perineural invasion, intraluminal crystalloids, blue mucin secretions, the absence of corpora amylacea, and the presence of coexistent high-grade prostatic intraepithelial neoplasia"
12/01/1997 - "These histologic findings included number of biopsy cores (mean 5.5), number of acini per focus of ASAP (mean 7.9), number of foci (mean one), variation in acinar size, nuclear enlargement (none, 12% of cases; mild, 45%; moderate, 33%; severe, 10%), nucleolar enlargement (none, 27%; mild, 46%; moderate, 27%), luminal mucin (39%), crystalloids (6%), focal chronic inflammation (64%), adjacent atrophy (100%), and adjacent high-grade prostatic intraepithelial neoplasia (PIN) (42%)"
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5. celecoxib (Celebrex)FDA Link
6. Selective Estrogen Receptor Modulators (SERM)IBA
7. SeleniumIBA
8. Messenger RNA (mRNA)IBA
9. Biological Markers (Surrogate Marker)IBA
10. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA

Therapies and Procedures

1. Chemoprevention
2. Prostatectomy (Retropubic Prostatectomy)
3. Aftercare (After-Treatment)
4. Transurethral Resection of Prostate (TURP)
5. Lasers (Laser)

Best Treatments:
Research Summary Report
on Prostatic Intraepithelial Neoplasia
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