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Integrins

A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors (RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.
Also Known As:
Integrin
Networked: 14304 relevant articles (440 outcomes, 1734 trials/studies)

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Experts

1. Chen, Xiaoyuan: 91 articles (01/2022 - 01/2004)
2. Davis, Paul J: 69 articles (06/2022 - 11/2006)
3. Lin, Hung-Yun: 54 articles (06/2022 - 11/2006)
4. Mousa, Shaker A: 51 articles (04/2022 - 08/2002)
5. Wang, Fan: 45 articles (01/2021 - 03/2007)
6. Kessler, Horst: 42 articles (01/2022 - 07/2003)
7. Sheppard, Dean: 40 articles (01/2022 - 01/2002)
8. Tang, Chih-Hsin: 39 articles (04/2022 - 01/2004)
9. Ivaska, Johanna: 37 articles (06/2022 - 02/2002)
10. Liu, Shuang: 35 articles (09/2017 - 08/2004)

Related Diseases

1. Neoplasms (Cancer)
2. Crohn Disease (Crohn's Disease)
3. Ulcerative Colitis
4. Inflammation (Inflammations)
5. Multiple Sclerosis

Related Drugs and Biologics

1. vedolizumab
2. Monoclonal Antibodies
3. Peptides (Polypeptides)
4. Natalizumab (Tysabri)
5. Ligands
6. Proteins (Proteins, Gene)
7. arginyl-glycyl-aspartic acid
8. Integrins
9. Fibronectins (Fibronectin)
10. Collagen

Related Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Lasers (Laser)
4. Radiotherapy
5. Immunotherapy