Abstract | BACKGROUND: OBJECTIVE: METHODS: 129 d gestational age lambs (n = 5-8/gp; term = 150 d) were operatively delivered and ventilated after exposure to either 1) no medication, 2) antenatal maternal IM Betamethasone 0.5 mg/kg 24 h prior to delivery, 3) 0.5 mg/kg Dexamethasone IV at delivery or 4) Cortisol 2 mg/kg IV at delivery. Lambs then were ventilated with no PEEP and escalating tidal volumes (VT) to 15 mL/kg for 15 min and then given surfactant. The lambs were ventilated with VT 8 mL/kg and PEEP 5 cmH20 for 2 h 45 min. RESULTS: CONCLUSIONS:
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Authors | Noah H Hillman, J Jane Pillow, Molly K Ball, Graeme R Polglase, Suhas G Kallapur, Alan H Jobe |
Journal | Respiratory research
(Respir Res)
Vol. 10
Pg. 124
(Dec 15 2009)
ISSN: 1465-993X [Electronic] England |
PMID | 20003512
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adrenal Cortex Hormones
- Anti-Inflammatory Agents
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Topics |
- Adrenal Cortex Hormones
(administration & dosage)
- Animals
- Anti-Inflammatory Agents
(administration & dosage)
- High-Frequency Ventilation
(adverse effects)
- Lung Injury
(etiology, prevention & control, veterinary)
- Prenatal Care
(methods)
- Sheep
- Treatment Outcome
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