Acute-Phase Reaction

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2604 relevant articles (39 outcomes, 207 trials/studies) found for this Disease

Description: An early local inflammatory reaction to insult or injury that consists of fever, an increase in inflammatory humoral factors, and an increased synthesis by hepatocytes of a number of proteins or glycoproteins usually found in the plasma.

Also Known As:

Acute Phase Reaction; Acute Phase State; Acute-Phase Response; Reaction, Acute Phase; Response, Acute Phase; State, Acute-Phase; Acute-Phase State; Reaction, Acute-Phase; Response, Acute-Phase

Relationship Network

Disease Context: Research Results

Signs and Symptoms Pathological Conditions

Pathologic Processes: 2442

Inflammation: 76220

Acute-Phase Reaction: 2604

Related Diseases

1.	Pain (Aches)
2.	Abscess
3.	Inflammation
4.	Neoplasms (Cancer)
5.	Stroke (Strokes)

Experts

1.	Grunfeld, Carl: 6 articles (09/2007 - 04/2002)
2.	Feingold, Kenneth R: 5 articles (09/2007 - 04/2002)
3.	Moser, Arthur H: 4 articles (09/2007 - 04/2002)
4.	Shigenaga, Judy K: 4 articles (09/2007 - 04/2002)
5.	Jeschke, M G: 4 articles (05/2000 - 02/2000)
6.	Herndon, D N: 4 articles (05/2000 - 02/2000)
7.	Barrow, R E: 4 articles (05/2000 - 02/2000)
8.	Poznanović, Goran: 3 articles (01/2008 - 09/2005)
9.	Petrović, Miodrag: 3 articles (01/2008 - 09/2005)
10.	Bogojević, Desanka: 3 articles (01/2008 - 09/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Acute-Phase Reaction:

1.	Interleukin-6 (Interleukin 6)IBA 04/01/1994 - "The serum concentration of TNF of IL-6 does not correlate with the presence of an acute-phase response, whereas rates of cytokine production by peripheral blood mononuclear cells are significantly greater in patients with such a response. " 11/01/2006 - "Interleukin-6 (IL-6) is a major regulator of the acute phase reaction in the liver and is thought to mediate protective effects in response to hepatotoxins. " 02/01/2004 - "The goal of this study was to determine if there is a relationship between urine albumin excretion and interleukin-6, a key mediator of acute phase reaction. " 03/01/2001 - "Physical examination was noncontributory, and extensive studies revealed only a marked acute-phase response associated with increased serum IL-6 levels. " 03/01/1996 - "Serum levels of albumin and interleukin-6 (IL-6) were compared with CRP levels in order to study the acute phase response. " Order ALL the reference details at left...
2.	C-Reactive ProteinIBA 02/01/2004 - "The decreased PLP levels occurred despite a significant improvement in the acute phase response (increased albumin [P < 0.001] and reduced C-reactive protein levels [P < 0.01]). " 01/01/1995 - "A C-reactive protein level is helpful in identifying the acute-phase response. " 03/01/2005 - "The aim of the present study was to evaluate (1) the relation between the MBL pathway and postoperative infectious complications and survival of patients resected for CRC, and (2) the role of MBL in acute phase response compared to C-reactive protein (CRP). " 10/06/1997 - "It is often of great clinical value to monitor the acute phase response in humans but the assays used to measure the acute response in man (e.g., erythrocyte sedimentation rate and C-reactive protein) is less well suited for experimental studies in the rat. " 12/01/1979 - "Studies of the acute phase response were carried out in nine patients following elective surgery, with C-reactive protein (CRP) used as the control protein: six patients showed no rise in beta 1H levels and three showed a small (20%) rise whereas all exhibited a gross rise in CRP. " Order ALL the reference details at left...
3.	Fibrinogen (Factor I)IBA 11/01/2007 - "They were found to be significantly younger and lean, had an improved lipid profile and an attenuated acute-phase response in terms of lower erythrocyte sedimentation rate and fibrinogen concentration as well as white blood cell count. " 01/01/2007 - "Our conclusion is that the pro-aggregating properties of fibrinogen following intense physical activity are probable counterbalanced by the anti-aggregatory properties of an improved lipid profile and an attenuated acute phase response." 08/01/1993 - "The results of these studies confirmed the induction of the acute-phase response by mrIL-6, as reflected in an approximate doubling in circulating levels of fibrinogen and C3. " 08/01/1986 - "The technique was then employed in a limited clinical study of nine patients undergoing infrainguinal vascular reconstruction to evaluate the effect of operation and the associated increase in serum fibrinogen levels, resulting from the acute phase reaction, on blood viscosity. " 08/01/2007 - "Fibrinogen is an essential component of the coagulation cascade and the acute phase response. " Order ALL the reference details at left...
4.	TurpentineIBA 07/01/2007 - "In the present study, turpentine oil was injected in the hind limb muscle of the rat to stimulate an acute-phase response (APR). " 01/15/2006 - "METHODS: To study the way in which the acute-phase response induced by sterile tissue injury influences pulmonary host defense, mice were injected subcutaneously with turpentine or saline in both hind limbs either 2 or 5 days before intranasal inoculation with A. " 04/01/2004 - "These in vitro results were confirmed by in vivo studies in IL-6(-/-) mice injected with turpentine, an experimental model of acute-phase response. " 01/01/1996 - "In this study, an acute phase response was induced by subcutaneous turpentine injection in rats. " 01/01/2009 - "To this end, we compared a female Wistar rat model of 50% 6-week-long dietary restriction with the standard laboratory model for the acute phase response induced by turpentine administration. " Order ALL the reference details at left...
5.	Interleukin-1 (Interleukin 1)IBA 07/01/1999 - "Our data suggest that centrally injected IL-1 induces higher circulating and hepatic IL-1 levels and contributes to the fact that the i.c.v. route of administration is particularly effective in inducing a liver acute-phase response." 12/01/1997 - "The objective was to study the relationship between the levels of interleukin-1 receptor antagonist (IL-1Ra) and disease activity and the acute-phase response in SLE patients with and without renal involvement. " 01/01/2008 - "In the liver, IL-1 initiates the acute phase response resulting in an increase in hepatic protein synthesis and decreased albumin production IL-1 also plays an important role in immune functions, having effects on macrophages/monocytes, T lymphocytes, B lymphocytes, NK cells, and LAK cells. " 02/16/2007 - "Interleukin-1 receptor antagonist induction as an additional mechanism for liver receptor homolog-1 to negatively regulate the hepatic acute phase response." 06/28/2004 - "Interleukin-1 (IL-1) is the principal pro-inflammatory cytokine participating in the initiation of acute phase response. " Order ALL the reference details at left...
6.	NF-kappa B (NF-kB)IBA 01/01/2007 - "CONCLUSION: T(3) administration involving transient oxidative stress in the liver exerts significant protection against IR injury, a novel preconditioning maneuver that is associated with NF-kappaB and STAT3 activation and acute-phase response." 06/01/2009 - "Both Stat3 and NF-kappaB have been shown to regulate the expression of genes involved in inflammatory signalling and the acute phase response. " 09/01/2007 - "The upcoming group of NF-kappaB inhibitors may have a place in the treatment of the acute-phase response." 09/01/2002 - "NF-kappaB plays a role in immune response, cellular adhesion or acute phase response. " 03/01/2000 - "In the adult liver, activation of the NF-kappaB heterodimer RelA/p50 can cause hepatocyte proliferation, apoptosis, or the induction of acute-phase response genes. " Order ALL the reference details at left...
7.	Insulin-Like Growth Factor I (IGF-1)IBA 03/01/2000 - "Although IGF-1 has been shown to improve cell recovery and play a major role in liver regeneration, its effect on the hepatic acute phase response is not known. " 03/01/1997 - "Measurement of plasma IGF-1 may be helpful in the presence of an acute-phase response, but this requires further validation. " 07/01/2002 - "We conclude that this model of enteric disease invokes an acute phase response accompanied by decreases in feed intake and serum IGF-I. Furthermore, dietary QS, at the levels fed in this study, appears to offer little benefit to growth performance or immune function in the presence or absence of ST-challenge." 02/01/1997 - "Treatment with a therapeutic dose of rHuGH can rectify the IGF-1 deficiency within 4 days, but its effect is adversely influenced by the acute-phase response, as reflected by an elevated CRP level." 02/01/1995 - "GH and IGF-I plasma concentrations were measured in lambs during an acute phase response induced by an intrathoracic injection of yeast. " Order ALL the reference details at left...
8.	CytokinesIBA 08/01/2002 - "The possibility of a decreased renal clearance of CRP and/or cytokines as a cause of an activated acute-phase response is discussed. " 07/07/2005 - "Irradiation is likely to cause an acute phase response, and the cytokines studied may be used to monitor this clinically important response in further trials." 01/01/2004 - "Several in vivo studies have demonstrated an acute-phase reaction after the first administration of aminobisphosphonates, with a significant increase in the main pro-inflammatory cytokines. " 11/01/1998 - "In the present study, we have analyzed the direct effects of cytokines, which mediate the acute-phase response in liver, on connexin expression and gap-junctional intercellular communication in immortalized MHSV12 mouse hepatocytes. " 03/01/1998 - "Blood samples were taken to study temporal relationships between changing plasma levels of proinflammatory cytokines and the periparturient acute phase response following prostaglandin (PG)-induced luteolysis at Day 275 of gestation. " Order ALL the reference details at left...
9.	Acute-Phase Proteins (Acute-Phase Protein)IBA 11/01/2006 - "The study demonstrates that the effects of MIF upon the acute phase response are complex and can differentially modulate the production of acute phase proteins depending on the presence of other factors." 10/01/2004 - "However, multiple studies have shown that a sustained or increased acute phase response is detrimental with the uncontrolled and prolonged action of acute phase proteins. " 03/27/2004 - "As part of a study of the development of hoof horn haemorrhages in first-lactation heifers, measurements were made of acute phase reactants to investigate the link between the acute phase response and the development of the haemorrhages. " 06/01/1993 - "Studies on the relationship between acute-phase protein (APP) production, clinical disease activity and progression of radiological damage in RA have been hampered by three factors: patients are studied at different stages of the disease; APP levels are taken incidentally rather than serially; and inter-individual differences in the relationship between the extent of the acute-phase reaction and the progression of radiological damage are not accounted for. " 06/01/1991 - "This rat model was used to study acute phase protein synthesis and the role of Kupffer cells in acute phase response (APR). " Order ALL the reference details at left...
10.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/01/1995 - "The impressive potential of anti-TNF alpha which was already illustrated by the immediate suppression of the acute phase response in open studies could be confirmed by a recently completed controlled trial. " 10/01/2008 - "Results reinforce the hypothesis that TNF-alpha is involved in physiological sleep regulation but plays a limited role in the acute-phase response induced by influenza virus." 04/01/2007 - "Tumor necrosis factor-alpha production due to stimulation by fecal precipitates obtained during LKM512 yogurt consumption tended to be higher than due to stimulation by precipitates obtained from preconsumption (P=0.0827), although acute phase response was suppressed by LKM512 yogurt consumption. " 04/01/2005 - "Despite the reports of muscle damage and soreness, no evidence of an acute phase response was observed (p > 0.05), which may be explained by the failure of the race to induce a plasma TNF-alpha response. " 03/01/2002 - "Role of the maternal acute phase response and tumor necrosis factor alpha in the developmental toxicity of lipopolysaccharide in the CD-1 mouse." Order ALL the reference details at left...

Therapies and Procedures

1.	Transplants (Transplant) 03/15/2003 - "The aim of this study is to investigate the gene expression pattern of acute phase response in relation to graft size in a rat-liver transplantation model. " 01/01/1992 - "Due to the stress imposed by the process of bone marrow transplantation (BMT), we hypothesized that individuals receiving such a transplant underwent an acute phase response (APR). " 12/01/2001 - "Endovascular stent-graft placement versus conventional open surgery in infrarenal aortic aneurysm: a prospective study on acute phase response and clinical outcome." 04/01/2009 - "In contrast, microarray studies in human renal transplant implantation biopsies indicate a strong acute phase response in the deceased donor kidney, associated with a significant upregulation of oncostatin M receptor beta (OSMR). " 01/01/1997 - "This I-R injury can contribute to graft dysfunction which stems in part from the acute phase response and a resultant host of cytokines. " Order ALL the reference details at left...
2.	Intraperitoneal Injections 02/01/2006 - "METHODS: First, a mouse model of acute phase response was established by intraperitoneal injection of LPS. " 03/01/2002 - "Induction of an acute phase response in connexin-32-deficient mice by intraperitoneal injection of lipopolysaccharide increased dye coupling by 33%, probably due to upregulation of connexin-26-containing gap junction channels." 04/01/2000 - "Although intraperitoneal injection of mIL-1, mIL-6 as well as mTNF-alpha did not induce an acute-phase response, Cx32 protein expression was diminished, suggesting that post-transcriptional downregulation of Cx32 preceded the acute-phase response. " 04/01/2000 - "Acute-phase response was triggered by intraperitoneal injection of lipopolysaccharide (LPS). " 10/01/1991 - "The acute-phase reaction was induced by intraperitoneal injections of bacterial lipopolysaccharide (LPS). " Order ALL the reference details at left...
3.	Enteral Nutrition (Feeding, Tube) 03/01/1998 - "The acute phase response and disease severity scores were significantly improved following enteral nutrition (CRP: 156 (117-222) to 84 (50-141), p < 0.005; APACHE II scores 8 (6-10) to 6 (4-8), p < 0.0001) without change in the CT scan scores. " 03/13/2005 - "Enteral feeding seems to be the only proven tool in attenuating acute phase response and improving disease severity." 01/01/2003 - "Modulation by enteral nutrition of the acute phase response and immune functions." 03/01/1998 - "Compared with parenteral nutrition, enteral feeding attenuates the acute phase response and improves disease severity in acute pancreatitis." 12/01/2002 - "BACKGROUND: In patients with major trauma and burns, total enteral nutrition (TEN) significantly decreases the acute phase response and incidence of septic complications when compared with total parenteral nutrition (TPN). " Order ALL the reference details at left...
4.	Cardiopulmonary Bypass (Heart-Lung Bypass) 12/01/2007 - "This study characterized compositional changes in LDL and HDL during the acute phase response following cardiac surgery with cardiopulmonary bypass. " 08/01/1996 - "This study demonstrated a marked acute-phase response to operation; the greater response to procedures with cardiopulmonary bypass was abrogated by intraoperative steroid administration. " 07/01/2008 - "BACKGROUND: Cardiac surgery with cardiopulmonary bypass (CPB) induces an acute phase reaction that is implicated in the pathogenesis of several postoperative complications. " 08/01/2007 - "OBJECTIVE: Cardiopulmonary bypass-induced acute liver injury is a life-threatening complication thought to be associated with the inflammatory response and the acute-phase response. " 06/01/2007 - "OBJECTIVE: Cardiopulmonary bypass (CPB)-induced acute liver injury is a life-threatening complication after cardiac surgery and is thought to be associated with inflammatory response and acute-phase response (APR). " Order ALL the reference details at left...
5.	Hepatectomy 05/01/2009 - "Effect of excessive acute-phase response on liver regeneration after partial hepatectomy in rats." 10/01/2002 - "CONCLUSIONS: After partial hepatectomy, plasma vWf is increased, probably due to both acute-phase reaction and decreased degradation. " 06/01/2001 - "Kinetics and mechanisms of hepatic acute phase response to subtotal partial hepatectomy and cultural impact on environmental hepatic end-stage liver injury in the homeless." 01/01/1996 - "Reduction of hepatic acute phase response after partial hepatectomy in elderly patients." 01/05/1988 - "Partial hepatectomy of adult rats induced both an acute phase response and regenerative growth in liver. " Order ALL the reference details at left...

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