Abstract | BACKGROUND: Evening meals that are rich in nondigestible carbohydrates have been shown to lower postprandial glucose concentrations after ingestion of high-glycemic-index breakfasts. This phenomenon is linked to colonic fermentation of nondigestible carbohydrates, but the underlying mechanism is not fully elucidated. OBJECTIVE: We examined the way in which glucose kinetics and related factors change after breakfast as a result of colonic fermentation. DESIGN: RESULTS: The plasma glucose response after the glucose drink was 29% lower after the BA evening meal (P = 0.019). The insulin response was the same, whereas mean (+/-SEM) tissue glucose uptake was 30% higher (20.2 +/- 1.9 compared with 15.5 +/- 1.8 mL/2 h; P = 0.016) after the BA evening meal, which indicated higher peripheral insulin sensitivity (P = 0.001). The 4-h mean postprandial interleukin-6 (19.7 +/- 5.1 compared with 5.1 +/- 0.7 pg/mL; P = 0.024) and tumor necrosis factor-alpha (7.8 +/- 2.1 compared with 5.3 +/- 1.6 pg/mL; P = 0.008) concentrations after the glucose drink were higher after the WB evening meal. Butyrate concentrations (P = 0.041) and hydrogen excretion (P = 0.005) were higher in the morning after the BA evening meal. CONCLUSION:
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Authors | Marion G Priebe, Hongwei Wang, Desiree Weening, Marianne Schepers, Tom Preston, Roel J Vonk |
Journal | The American journal of clinical nutrition
(Am J Clin Nutr)
Vol. 91
Issue 1
Pg. 90-7
(Jan 2010)
ISSN: 1938-3207 [Electronic] United States |
PMID | 19889821
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Carbon Isotopes
- Dietary Carbohydrates
- Insulin
- Interleukin-6
- Tumor Necrosis Factor-alpha
- Hydrogen
- Glucose
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Topics |
- Blood Glucose
(metabolism)
- Bread
- Breath Tests
- Carbon Isotopes
- Colon
(metabolism)
- Cross-Over Studies
- Dietary Carbohydrates
(metabolism)
- Fermentation
- Glucose
(adverse effects)
- Glucose Tolerance Test
- Hordeum
- Humans
- Hydrogen
(analysis)
- Inflammation
(chemically induced, physiopathology)
- Insulin
(blood)
- Interleukin-6
(blood)
- Isotope Labeling
- Male
- Postprandial Period
- Random Allocation
- Tumor Necrosis Factor-alpha
(blood)
- Young Adult
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