Pneumomediastinum and subcutaneous emphysema secondary to amyopathic dermatomyositis with cryptogenic organizing pneumonia in invasive breast cancer: a case report and review of literature.

Abstract

Amyopathic dermatomyositis (ADM) is recognized as a variant phenotype of dermatomyositis and characterized by typical skin manifestations without evidence of muscular inflammation. While interstitial lung disease (ILD) is occasionally found as one of the lung manifestations in ADM patients, the development of a pneumomediastinum and/or subcutaneous emphysema in this disease entity is one of the extremely rare pulmonary complications. These latter complicated pulmonary manifestations have been usually reported in idiopathic ADM with ILD without any other associated medical conditions. We report a case presented with the spontaneous pneumomediastinum and subcutaneous emphysema in both ADM and cryptogenic organizing pneumonia during adjuvant chemotherapy based on cyclophosphamide for breast cancer.

• Authors: Sung Hwan Park, Yoon-Seup Kum, Kyung-Chan Kim, Jung-Yoon Choe, Sung-Hoon Park, Seong-Kyu Kim
• Journal: Rheumatology international (Rheumatol Int) Vol. 29 Issue 10 Pg. 1231-5 (Aug 2009) ISSN: 1437-160X [Electronic] Germany
• PMID: 19093118 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Immunosuppressive Agents
• Cyclophosphamide

Topics

• Breast Neoplasms (complications, drug therapy, pathology)
• Chemotherapy, Adjuvant (methods)
• Cryptogenic Organizing Pneumonia (diagnosis)
• Cyclophosphamide (therapeutic use)
• Dermatomyositis (complications, diagnosis)
• Female
• Follow-Up Studies
• Humans
• Immunosuppressive Agents (therapeutic use)
• Lung (diagnostic imaging)
• Mediastinal Emphysema (complications, diagnosis, diagnostic imaging)
• Middle Aged
• Neoplasm Invasiveness
• Radiography
• Subcutaneous Emphysema (diagnostic imaging, etiology)
• Time Factors
• Treatment Outcome