Bronchial diffusing capacity of nitric oxide is increased in patients with allergic rhinitis.

Abstract

BACKGROUND:

Exhaled nitric oxide (NO) measurement at multiple exhalation flow rates allows calculation of flow-independent NO parameters: alveolar NO concentration, bronchial NO flux, bronchial diffusing capacity of NO and bronchial wall NO concentration.

METHODS:

In the present study, we measured the flow-independent NO parameters and inflammatory markers in exhaled breath condensate (EBC) and in serum in 14 patients with seasonal allergic rhinitis (AR) without asthma, and in 14 age- and sex-matched healthy volunteers.

RESULTS:

At symptomatic stage before the treatment, patients with AR had higher bronchial wall diffusing capacity of NO than healthy volunteers (p = 0.024), but there were no differences in bronchial wall NO concentration or alveolar NO concentration. Patients with AR had also increased 8-isoprostane levels in the EBC (p = 0.040), and increased serum levels of IgE (p = 0.002) and eosinophil cationic protein (ECP; p = 0.027). Two-week treatment with nasal glucocorticoid mometasone decreased symptom scores and serum ECP levels but had no effect on NO parameters or 8-isoprostane levels in EBC.

CONCLUSIONS:

Noninvasive markers of airway inflammation showed subclinical lower airway inflammation in patients with AR without asthma, but short-term treatment with nasal glucocorticoids did not affect most of the markers of lower airway inflammation.

• Authors: Tarja Makinen, Lauri Lehtimäki, Hannele Kinnunen, Riina Nieminen, Hannu Kankaanranta, Eeva Moilanen
• Journal: International archives of allergy and immunology (Int Arch Allergy Immunol) Vol. 148 Issue 2 Pg. 154-60 ( 2009) ISSN: 1423-0097 [Electronic] Switzerland
• PMID: 18802360 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2008 S. Karger AG, Basel.

Chemical References

• Biomarkers
• Glucocorticoids
• Pregnadienediols
• Mometasone Furoate
• 8-epi-prostaglandin F2alpha
• Nitric Oxide
• Dinoprost
• Eosinophil Cationic Protein

Topics

• Adult
• Biomarkers
• Breath Tests
• Bronchi (physiopathology)
• Dinoprost (analogs & derivatives, metabolism)
• Eosinophil Cationic Protein (metabolism)
• Female
• Glucocorticoids (therapeutic use)
• Humans
• Inflammation (drug therapy, immunology, metabolism, physiopathology)
• Male
• Mometasone Furoate
• Nitric Oxide (metabolism)
• Pregnadienediols (therapeutic use)
• Respiratory Function Tests
• Rhinitis, Allergic, Perennial (drug therapy, immunology, metabolism, physiopathology)
• Young Adult