Abstract |
The aim of this study was to analyze LPIN1 adipose tissue gene expression levels in 3 clinical insulin-resistant conditions- obesity, type 2 diabetes mellitus, and human immunodeficiency virus ( HIV)-associated lipodystrophy-and its relationship with adipogenic and inflammatory markers. Subcutaneous adipose tissue samples were obtained from 2 cohorts: 98 subjects with different degrees of adiposity and with or without the presence of type 2 diabetes mellitus and 37 HIV-infected patients. Real-time polymerase chain reaction was used to measure gene expression of LPIN1 and adipogenic ( PPARgamma, SREBP1c) and inflammatory markers ( IL6, TNFalpha, TNFR1, and TNFR2). LPIN1 messenger RNA expression levels were significantly lower in the obese group (P = .002), were similar in type 2 diabetes mellitus patients and control subjects (P = .211), and were significantly higher in HIV-infected patients (P < .001). LPIN1 messenger RNA levels positively correlated with insulin sensitivity in all subjects. Moreover, an inverse correlation with proinflammatory cytokines was observed.
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Authors | Merce Miranda, Matilde R Chacón, José Gómez, Ana Megía, Victòria Ceperuelo-Mallafré, Sergi Veloso, María Saumoy, Lluís Gallart, Cristóbal Richart, Jose Manuel Fernández-Real, Joan Vendrell, Adipocyte Differentiation Study Group |
Journal | Metabolism: clinical and experimental
(Metabolism)
Vol. 56
Issue 11
Pg. 1518-26
(Nov 2007)
ISSN: 0026-0495 [Print] United States |
PMID | 17950103
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Nuclear Proteins
- LPIN1 protein, human
- Phosphatidate Phosphatase
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Topics |
- Adult
- Cohort Studies
- Diabetes Mellitus, Type 2
(metabolism)
- Female
- HIV Infections
(complications, metabolism)
- Humans
- Lipodystrophy
(complications, metabolism)
- Male
- Middle Aged
- Nuclear Proteins
(genetics, metabolism)
- Obesity
(metabolism)
- Phosphatidate Phosphatase
- Subcutaneous Fat
(metabolism)
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