Abstract | BACKGROUND: METHODS: RESULTS: At presentation, three patients were receiving etanercept, one adalimumab and one infliximab. Two subjects presented with acute renal insufficiency, haematuria, nephrotic-range proteinuria, positive lupus serologies, and hypocomplementemia, and renal biopsies showed proliferative lupus nephritis. Two individuals presented with new onset renal insufficiency, haematuria and proteinuria, and renal biopsies showed pauci-immune necrotizing and crescentic glomerulonephritis. One of these subjects, who had anti- myeloperoxidase autoantibodies, also developed pulmonary vasculitis. The fifth patient presented with nephrotic syndrome and renal biopsy findings of membranous glomerulonephritis, associated with immune complex renal vasculitis. A pathogenic role for anti- TNFalpha therapy is suggested by the close temporal relationship with development of glomerular disease, and by the improvement in clinical and laboratory abnormalities after drug withdrawal and initiation of immunosuppressive therapy in most cases. CONCLUSIONS:
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Authors | Michael B Stokes, Kirk Foster, Glen S Markowitz, Farhang Ebrahimi, William Hines, Darren Kaufman, Brooke Moore, Daniel Wolde, Vivette D D'Agati |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 20
Issue 7
Pg. 1400-6
(Jul 2005)
ISSN: 0931-0509 [Print] England |
PMID | 15840673
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Humanized
- Antirheumatic Agents
- Immunoglobulin G
- Receptors, Tumor Necrosis Factor
- Tumor Necrosis Factor-alpha
- Infliximab
- Adalimumab
- Etanercept
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Topics |
- Adalimumab
- Adult
- Antibodies, Monoclonal
(adverse effects)
- Antibodies, Monoclonal, Humanized
- Antirheumatic Agents
(adverse effects)
- Arthritis, Rheumatoid
(complications, drug therapy, genetics)
- Etanercept
- Female
- Glomerulonephritis
(chemically induced, genetics, pathology)
- Humans
- Immunoglobulin G
(adverse effects)
- Infliximab
- Male
- Middle Aged
- Receptors, Tumor Necrosis Factor
- Tumor Necrosis Factor-alpha
(antagonists & inhibitors)
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