Lupus Nephritis

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2126 relevant articles (199 outcomes, 300 trials/studies) found for this Disease

Description: Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).

Also Known As:

Glomerulonephritides, Lupus; Lupus Glomerulonephritides; Lupus Nephritides; Nephritides, Lupus; Glomerulonephritis, Lupus; Lupus Glomerulonephritis; Nephritis, Lupus

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Proteinuria
2.	Systemic Lupus Erythematosus (Libman-Sacks Disease)
3.	Vasculitis (Vasculitides)
4.	Glomerulonephritis
5.	Nephrotic Syndrome (Syndrome, Nephrotic)

Experts

1.	Tanaka, H: 7 articles (09/2007 - 10/2001)
2.	Nose, Masato: 7 articles (07/2007 - 03/2002)
3.	Berden, Jo H M: 6 articles (10/2008 - 11/2002)
4.	Anders, Hans-Joachim: 6 articles (04/2008 - 06/2004)
5.	Putterman, Chaim: 6 articles (01/2008 - 03/2004)
6.	Ito, E: 6 articles (09/2007 - 12/2003)
7.	Tsugawa, K: 6 articles (09/2007 - 12/2003)
8.	Chan, T M: 6 articles (01/2007 - 10/2000)
9.	Chen, Min: 6 articles (07/2006 - 11/2002)
10.	Mok, Chi Chiu: 6 articles (04/2006 - 04/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Lupus Nephritis:

1.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 08/01/1989 - "Bolus intravenous cyclophosphamide therapy (IVCY) has recently been the subject of considerable attention because it is occasionally very effective in the treatment of severe lupus nephritis. " 08/01/1989 - "[A case of lupus nephritis resistant to steroid pulse therapy markedly improved by bolus intravenous cyclophosphamide therapy]" 03/01/2005 - "This house believes that low-dose intravenous cyclophosphamide is superior to standard high-dose regimes for treatment of lupus nephritis." 05/01/2003 - "Efficacy of low-dose versus high-dose cyclophosphamide in lupus nephritis: comment on the article by Houssiau et al." 12/01/1996 - "OBJECTIVE: To determine the cumulative rate of relapse of lupus nephritis that has been treated successfully with cyclophosphamide (CYC), and to estimate the association between time to relapse and demographic, clinical, laboratory, and treatment variables. " Order ALL the reference details at left...
2.	mycophenolate mofetil (Cellcept)FDA LinkGeneric 11/01/2005 - "Short-term to intermediate-term, randomized controlled trials have shown that mycophenolate mofetil is a good option for the induction and maintenance of remission in lupus nephritis patients. " 11/24/2005 - "BACKGROUND: Since anecdotal series and small, prospective, controlled trials suggest that mycophenolate mofetil may be effective for treating lupus nephritis, larger trials are desirable. " 01/01/2008 - "The efficacy of mycophenolate mofetil in the treatment of patients with lupus nephritis has been recently established in several clinical trials. " 01/01/2004 - "Mycophenolate mofetil (MMF) is a potential new treatment for diffuse proliferative lupus nephritis. " 07/01/2009 - "The purpose of this study is to evaluate the effectiveness and safety of mycophenolate mofetil (MMF) for inducing and/or maintaining remission of lupus nephritis (LN). " Order ALL the reference details at left...
3.	Azathioprine (Imuran)FDA LinkGeneric 09/01/2000 - "Long-term efficacy of azathioprine treatment for proliferative lupus nephritis." 08/01/2009 - "Azathioprine, the Cinderella in the treatment of lupus nephritis." 04/01/2009 - "Azathioprine is commonly used for treatment of lupus nephritis. " 01/01/2003 - "Azathioprine can be regarded as an effective drug for maintenance treatment of lupus nephritis. " 12/01/1989 - "All of these, except for azathioprine, reduced disease severity, assessed as the development of lupus nephritis. " Order ALL the reference details at left...
4.	Methylprednisolone FDA LinkGeneric 04/01/1981 - "High-dose intravenous methylprednisolone therapy may lead to striking improvement in renal function in lupus nephritis, especially in the subset of patients with recent antecedent functional deterioration. " 01/01/1994 - "Long term efficacy of high-dose intravenous methylprednisolone pulses in active lupus nephritis. " 03/01/1989 - "Lupus nephritis: efficacy of monthly pulse therapy with intravenous methylprednisolone." 01/01/2007 - "Predictive factors of clinical outcome in patients with diffuse proliferative lupus nephritis treated early by intravenous methylprednisolone pulse therapy." 10/01/2001 - "Six Japanese children with severe lupus nephritis received prompt initiation of methylprednisolone pulse therapy (MPT). " Order ALL the reference details at left...
5.	rituximab (Mabthera)FDA Link 08/01/2009 - "There were no statistically significant differences in the proportion of patients with complete depletion at weeks 4, 8, 24 and 48 between the two groups except at week 2. CONCLUSIONS: Rituximab monotherapy appears to be effective as induction therapy in lupus nephritis. " 01/01/2007 - "Rituximab has shown promise in patients with active proliferative lupus nephritis, which suggests that B-cell depletion may be successful. " 04/01/2007 - "For patients with proliferative lupus nephritis who fail to respond to conventional immunosuppressive therapy including CYC, combined treatment with rituximab and CYC may constitute a new treatment option." 09/01/2009 - "The accumulation of positive results therefore stands in stark contrast to the recent reports that two phase III randomized placebo controlled trials employing B cell depletion with rituximab in nonlupus and lupus nephritis (Explorer and Lunar, respectively) did not achieve. " 02/01/2005 - "This open-label study was undertaken to evaluate the efficacy of the anti-CD20 monoclonal antibody rituximab in the treatment of lupus nephritis. " Order ALL the reference details at left...
6.	Prednisone (Sone)FDA LinkGeneric 02/01/2004 - "CONCLUSION: A combination of prednisone and AZA is reasonably effective for the initial treatment of pure membranous lupus nephritis. " 01/01/2004 - "In conclusion, MMF/prednisone therapy was effective for our patients with proliferative lupus nephritis. " 02/01/2004 - "METHODS: Consecutive patients with pure membranous lupus glomerulonephritis (World Health Organization [WHO] Va and Vb) from 4 regional hospitals were recruited for an open-label treatment trial consisting of prednisone and AZA. " 01/01/2004 - "This study examines the clinical and histopathological effects, and potential mechanisms, of combination MMF/prednisone therapy in diffuse proliferative lupus nephritis. " 07/01/1982 - "In this study, 15 patients with biopsy-proven diffuse proliferative lupus nephritis were treated with oral high-dose prednisone therapy, initially 2 mg/kg/day. " Order ALL the reference details at left...
7.	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/01/2001 - "In contrast, treatment with cyclosporin A (CyA) resulted in a marked regression of these nodules within one month, together with a complete remission of both MRH and lupus nephritis. " 10/01/2001 - "Sustained remission in a case of lupus nephritis with cyclosporin therapy." 09/01/1993 - "As cyclosporine appeared to be effective in experimental models of lupus nephritis, some studies have been performed using this drug in patients with lupus nephritis. " 01/01/1999 - "Cyclosporine demonstrates some efficacy in treating proliferative lupus nephritis and, based on pilot study data, membranous lupus as well. " 09/01/1994 - "Anecdotal experience in patients with lupus nephritis suggests cyclosporine produces an improvement in symptoms, a decrease in protein excretion, and improvement in renal function when other treatments have failed. " Order ALL the reference details at left...
8.	Adrenal Cortex Hormones (Corticosteroids)IBA 01/01/1988 - "Corticosteroids form the mainstay of therapy for lupus nephritis, provided that they achieve a prompt clinical remission which can be sustained with alternate day therapy. " 12/01/2003 - "To relieve disease flare of lupus nephritis, a prospective pilot study of oral MZR pulse therapy (a phase II trial) is conducted as an alternative therapy to dose up of corticosteroids. " 01/01/2008 - "CONCLUSION: Both therapeutic approaches with MMF or AZA, in combination with corticosteroids, are effective as a maintenance therapy for lupus nephritis." 10/01/2005 - "CONCLUSIONS: MMF in combination with corticosteroids is an effective induction therapy for moderately severe proliferative lupus nephritis." 12/01/2003 - "CONCLUSION: Although we had no control subjects in this series, MZR oral pulse therapy may be of benefit to a proportion of patients with disease flare of lupus nephritis as an alternative therapy to dose up of corticosteroids." Order ALL the reference details at left...
9.	SteroidsIBA 01/01/2001 - "Recent studies suggest that it may also be effective in the treatment of patients with lupus nephritis when used in conjunction with steroids. " 11/01/1980 - "Treatment with steroids and/or immunosuppressives is effective in lupus nephritis; in other diseases, the results are less certain." 12/13/1984 - "We conclude that immunosuppressive drugs and steroids together are more effective than steroids alone in treating lupus nephritis and that published trials have reached false negative conclusions because of small sample sizes." 10/01/2008 - "Thus it was worthwhile to differentiate it from lupus nephritis, that is responsive to steroids." 01/01/2006 - "BACKGROUND: Long term cyclophosfamide combinated steroids therapy improves renal survival in patients with Proliferate Lupus Nephritis, with considerable toxic effects. " Order ALL the reference details at left...
10.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/01/2009 - "CONCLUSION: In intractable lupus nephritis, anti-TNF-alpha therapy improved urinary protein levels and SLE activity. " 05/01/2009 - "OBJECTIVE: To clarify the efficacy and safety of anti-TNF-alpha therapy for intractable lupus nephritis. " 05/01/2009 - "Anti-tumor necrosis factor therapy in patients with difficult-to-treat lupus nephritis: a prospective series of nine patients." 07/01/2000 - "Accelerated autoimmunity and lupus nephritis in NZB mice with an engineered heterozygous deficiency in tumor necrosis factor." 05/01/1992 - "These data suggest that TNF alpha and HLA are possibly associated with the severity of lupus nephritis." Order ALL the reference details at left...

Therapies and Procedures

1.	Plasmapheresis 10/01/1992 - "The Lupus Nephritis Collaborative Study Group published two papers, one of which concerned the lack of efficacy of plasmapheresis in treating severe lupus nephritis. " 01/01/1998 - "Plasmapheresis remains under study but has not shown additional benefit in treatment of severe lupus nephritis. " 09/01/1993 - "A controlled trial of plasmapheresis showed no benefit over standard regimens in lupus nephritis. " 09/01/1992 - "A total of 86 patients entered into the study of plasmapheresis in severe SLE GN by the Lupus Nephritis Collaborative Study Group, and long-term follow-up was available in 83. " 05/21/1992 - "A controlled trial of plasmapheresis therapy in severe lupus nephritis. " Order ALL the reference details at left...
2.	Transplants (Transplant) 01/01/2006 - "In lately years MMF, a immune suppressor used in transplant, seems to be effective in selected cases of Lupus Nephritis. " 06/01/2009 - "More recently, there has been increasing involvement of renal teams in clinical trials, particularly for lupus nephritis and renal transplant modulation." 10/27/1998 - "CONCLUSIONS: The present study confirms that patients with SLE can receive transplants with excellent graft and patient survival rates and a low rate of clinical recurrent lupus nephritis." 10/01/1991 - "No major double-blind studies of therapy for lupus nephritis were published; however, the course of lupus patients receiving dialysis or grafts was the subject of three interesting studies. " 08/15/2009 - "TWEAK stimulation of kidney resident cells in the pathogenesis of graft versus host induced lupus nephritis." Order ALL the reference details at left...
3.	Kidney Transplantation 03/15/2003 - "BACKGROUND: Although recurrent lupus nephritis (RLN) after kidney transplantation is reported to be rare (1%-4%), recent studies suggest a higher incidence. " 01/01/2009 - "A 25-year-old woman with a history of kidney transplantation for lupus nephritis was referred for the evaluation and management of a mass incidentally found on echocardiography. " 01/01/2008 - "Renal transplantation in patients with lupus nephritis: a single-center experience." 01/01/2006 - "Early recurrence of lupus nephritis after renal transplantation--a case report." 12/01/2005 - "Recurrence of lupus nephritis after renal transplantation: if we look for it, will we find it?" Order ALL the reference details at left...
4.	Plasma Exchange 10/01/1995 - "There is still controversy about the efficacy of plasma exchange in the treatment of severe lupus nephritis. " 06/01/2001 - "On the basis of currently available studies, plasma exchange used alone or as an adjunct to conventional immunosuppressive therapy offers no clear benefit over standard immunosuppression in patients with active lupus nephritis and therefore cannot be recommended. " 02/01/2003 - "Hydroxyethylstarch as a replacement fluid in therapeutic plasma exchange for lupus nephritis in a Jehovah's Witness." 06/01/1990 - "[The criteria for indication of plasma exchange on lupus nephritis]" 01/01/1990 - "Effect of therapeutic plasma exchange on immunological and renal pathological findings in patients with lupus nephritis." Order ALL the reference details at left...
5.	Transplantation (Transplant Recipients) 05/01/2008 - "BACKGROUND: Factors associated with outcome in renal transplant recipients with lupus nephritis have not been studied. " 09/01/2003 - "De novo lupus nephritis in a renal transplant recipient has not been previously reported. " 03/15/2003 - "Recurrent lupus nephritis in renal transplant recipients revisited: it is not rare." 03/27/2000 - "BACKGROUND: Two patients underwent cadaver transplantation with kidneys from a donor with a history of World Health Organization Class IV/V lupus nephritis, and we report their clinical and pathological outcome. " 03/27/2000 - "Transplantation and 2-year follow-up of kidneys procured from a cadaver donor with a history of lupus nephritis." Order ALL the reference details at left...

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