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Antigen-Antibody Complex (Immune Complex)

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The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.

Also Known As:

Immune Complex; Antigen-Antibody Complexes; Immune Complexes; Antigen Antibody Complex; Antigen Antibody Complexes; Complex, Antigen-Antibody; Complex, Immune; Complexes, Antigen-Antibody; Complexes, Immune

Networked: 8360 relevant articles (232 outcomes, 623 trials/studies) for this Bio-Agent, Comments

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Novak, Jan: 13 articles (07/2010 - 08/2002)
2.	Julian, Bruce A: 13 articles (07/2010 - 08/2002)
3.	Tomana, Milan: 11 articles (07/2010 - 08/2002)
4.	Mestecky, Jiri: 11 articles (07/2010 - 08/2002)
5.	Anders, Hans-Joachim: 11 articles (09/2009 - 02/2003)
6.	Haas, Mark: 10 articles (09/2009 - 01/2003)
7.	Monteiro, Renato C: 8 articles (07/2010 - 12/2003)
8.	Cook, H Terence: 8 articles (02/2010 - 08/2002)
9.	Ward, Peter A: 8 articles (11/2009 - 07/2002)
10.	D'Agati, Vivette D: 8 articles (11/2009 - 01/2004)

Related Diseases

1.	Glomerulonephritis 10/01/2005 - "Perhaps the best treatment for glomerulonephritis is the identification and correction of any underlying inflammatory, immune-mediated or neoplastic disease that results in the deposition or formation of glomerular immune complexes. " 01/01/1996 - "Glomerular structural damage expressed as glomerular damage index was significantly greater in rats with immune complex glomerulonephritis when compared with controls (immune complex glomerulonephritis 0.91 +/- 0.13; control 0.60 +/- 0.08; P < 0.05), but was uneffected by the treatment with the CEI (immune complex) glomerulonephritis + CEI 1.02 +/- 0.26; control + CEI 0.63 +/- 0.11). " 11/22/2003 - "Assuming that a decrease in CD2AP attenuates clearance of glomerular immune complexes, patients with other types of idiopathic glomerulonephritis should also have a CD2AP mutation. " 07/01/1982 - "Impairment of glomerular clearance of macroaggregates in immune complex glomerulonephritis." 11/15/2006 - "In this study, we found that TLR4 signaling to LPS can be positively enforced by expressing gp96 on cell surfaces through the chaperone function of, but not the direct signaling by, gp96; TLR4 as well as the commensal flora are essential for the production of anti-dsDNA Ab and the immune complex-mediated glomerulonephritis in transgenic mice that express surface gp96. " Order ALL the reference details at left...
2.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 12/01/2005 - "Hypocomplementaemia and low expression of CR1 on erythrocytes (E) of patients with systemic lupus erythematosus (SLE) are associated with defective clearance of circulating immune complexes (IC) and so they may have pathogenic significance. " 12/01/2000 - "Fcgamma receptor polymorphisms in systemic lupus erythematosus: association with disease and in vivo clearance of immune complexes." 01/01/2003 - "Studies of gene-targeted mice lacking specific FcgammaR have demonstrated that animals lacking activator FcgammaR on circulating leukocytes were protected from immune complex induced glomerular injury, both in models of systemic lupus erythematosus (SLE) and anti-glomerular basement membrane antibody disease. " 11/01/2002 - "OBJECTIVE: Studies of an Icelandic cohort showed that susceptibility to systemic lupus erythematosus (SLE) in individuals with C4A deficiency was increased only in the presence of increased concentrations of immune complexes. " 01/01/2001 - "A number of mouse models have been utilized to study the pathophysiology of immune complex (IC) disease, and the hallmark IC disease systemic lupus erythematosus (SLE). " Order ALL the reference details at left...
3.	Infection 07/01/1993 - "An alternative hypothesis is the possible role of defective clearance of immune complexes in the development of severe infections. " 07/01/1993 - "Pathogenesis can be related to occult infection, loss of mucosal barrier function, defective clearance of immune complexes, or aberrant immune responses. " 07/01/2004 - "These studies suggest that the presence of immune complexes in infection or autoimmunity may radically alter the nature of CD163-dependent monocyte/macrophage processes. " 11/01/1998 - "The aim of this study was to evaluate the usefulness of circulating immune complexes in the diagnosis of pneumococcal lower respiratory infection in children. " 10/01/1995 - "Our present study suggested that three mechanisms might contribute to the pathogenesis of HCV-related SjS: 1) direct infection and proliferation of HCV in salivary glands, 2) molecular mimicry between HCV and salivary glands, and 3) formation of immune complex containing HCV. " Order ALL the reference details at left...
4.	Vasculitis (Vasculitides) 12/01/1999 - "The deposition of circulating HCV-containing immune complexes (CIC) in the skin could be the initial pathogenic event for cryoglobulinemic vasculitis; subsequently CIC could spread from the vascular bed to the perivascular tissue and then could be very rapidly eliminated. " 03/15/1992 - "In studies of immune complex (BSA-anti-BSA)-induced alveolitis and dermal vasculitis, anti-CD18 had protective effects at all doses of anti-BSA employed. " 12/01/2006 - "Biopsy is the gold standard for the diagnosis of cutaneous vasculitis and also necessary for the detection of cutaneous vascular immune complexes by direct immunofluorescence. " 08/01/1989 - "Even vasculitis may be a consequence of failure of clearance of immune complexes from the interstitium. " 02/01/1997 - "Immunofluorescence study suggested the occurrence of an immune complex nephropathy and a pauci-immune pathogenesis of vasculitis. " Order ALL the reference details at left...
5.	Lung Injury 03/15/1992 - "Although anti-CD11b was not effective under the same experimental conditions, intratracheal administration of this antibody conveyed protection against immune complex-induced lung injury, suggesting that both CD11b and CD18 are required for the full expression of injury. " 12/01/2009 - "We propose that lung injury in response to immune complex deposition is dependent on Rac2 in alveolar macrophages and neutrophils." 01/01/2000 - "These results suggest that anti-CK18 antibody and its immune complex may have played a role in the process of lung injury in IPF." 05/01/1994 - "Our findings suggested an immune complex-mediated pulmonary injury that was possibly related to the systemic nature of IgAN." 08/01/1992 - "Using a well-characterized rat model of immune complex-mediated acute inflammatory lung injury, we determined that there is a time-dependent elaboration of monocyte chemotactic activity in bronchoalveolar lavage fluid. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Immunoglobulin G (IgG)
2.	Antibodies
3.	Complement System Proteins (Complement)
4.	Immunoglobulin A (IgA)
5.	Antigens
6.	Autoantibodies
7.	Immunoglobulin M (IgM)
8.	Antigen-Antibody Complex (Immune Complex)
9.	Immunoglobulins (Immunoglobulin)
10.	Rheumatoid Factor

Related Therapies and Procedures

1.	Plasmapheresis
2.	Plasma Exchange
3.	Drug Therapy (Chemotherapy)
4.	Splenectomy
5.	Intravenous Injections

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