Abstract | OBJECTIVE: A noninvasive bronchoscopic microsampling (BMS) probe was developed to sample biochemical constituents of the epithelial lining fluid in small airways. DESIGN: Observational, controlled study. SETTING: MEASUREMENTS AND RESULTS: Complications, including a significant decrease in arterial oxygen saturation, were observed neither during nor after BMS. In the ARDS group, albumin, lactate dehydrogenase, interleukin-6, basic fibroblast growth factor, and neutrophil elastase concentrations in epithelial lining fluid were significantly higher (p <.0001, p =.012, p <.0001, p <.0001, and p <.0001, respectively) than in the control group. Serial BMS was safely performed in one patient with ARDS, allowing us to observe a correlation between changes in the concentration of inflammation-related biochemical markers and clinical course of the disease. CONCLUSIONS: These results suggest that BMS is safe and useful to monitor pulmonary biochemical events in ARDS.
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Authors | A Ishizaka, M Watanabe, T Yamashita, Y Ogawa, H Koh, N Hasegawa, H Nakamura, K Asano, K Yamaguchi, M Kotani, T Kotani, H Morisaki, J Takeda, K Kobayashi, S Ogawa |
Journal | Critical care medicine
(Crit Care Med)
Vol. 29
Issue 4
Pg. 896-8
(Apr 2001)
ISSN: 0090-3493 [Print] United States |
PMID | 11373491
(Publication Type: Journal Article)
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Topics |
- Adult
- Aged
- Bronchoalveolar Lavage Fluid
(chemistry)
- Bronchoscopy
(methods)
- Case-Control Studies
- Female
- Humans
- Male
- Middle Aged
- Respiratory Distress Syndrome
(physiopathology)
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