Abstract |
In the course of our continuing search for novel cancer chemopreventive agents from natural sources, several kinds of Panax plants were screened. Consequently, the ocotillol-type saponin, majonoside-R2 (MR2), was obtained from the rhizome and root of Panax vietnamensis (Vietnamese ginseng) as an active constituent. MR2 exhibited potent anti- tumor-promoting activity on two-stage carcinogenesis test of mouse hepatic tumor using N-nitrosodiethylamine (DEN) as an initiator and phenobarbital (PB) as a promoter. Further, MR2 exhibited the remarkable inhibitory effect on two-stage carcinogenesis test of mouse skin induced by nitric oxide (NO) donor/12-O-tetradecanoylphorbol-13- acetate (TPA) or peroxynitrite/TPA.
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Authors | T Konoshima, M Takasaki, E Ichiishi, T Murakami, H Tokuda, H Nishino, N M Duc, R Kasai, K Yamasaki |
Journal | Cancer letters
(Cancer Lett)
Vol. 147
Issue 1-2
Pg. 11-6
(Dec 01 1999)
ISSN: 0304-3835 [Print] Ireland |
PMID | 10660083
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Alkylating Agents
- Anticarcinogenic Agents
- Carcinogens
- Ginsenosides
- Nitrates
- Nitro Compounds
- Saponins
- methyl-2-hydroxyimino-5-nitro-6-methoxy-3-hexeneamide
- peroxynitric acid
- Diethylnitrosamine
- majonoside R2
- Tetradecanoylphorbol Acetate
- Phenobarbital
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Topics |
- Alkylating Agents
- Animals
- Anticarcinogenic Agents
(isolation & purification, pharmacology)
- Carcinogenicity Tests
- Carcinogens
- Diethylnitrosamine
- Female
- Focal Nodular Hyperplasia
(chemically induced, prevention & control)
- Ginsenosides
- Liver Neoplasms, Experimental
(chemically induced, prevention & control)
- Mice
- Mice, Inbred ICR
- Mice, Inbred SENCAR
- Nitrates
- Nitro Compounds
- Panax
(chemistry)
- Papilloma
(chemically induced, prevention & control)
- Phenobarbital
- Plants, Medicinal
- Saponins
(isolation & purification, pharmacology)
- Skin Neoplasms
(chemically induced, prevention & control)
- Tetradecanoylphorbol Acetate
- Vietnam
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