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ocotillol

cardioprotective agent; structure in first source

Also Known As:

3alpha-ocotillol

Networked: 23 relevant articles (3 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - Ginsenosides: 1010
        ocotillol: 23
Carbohydrates: 22023
- Glycosides: 2119
  - Saponins: 2867
    - Ginsenosides: 1010
      - ocotillol: 23

Experts

1.	Yang, Jingyu: 9 articles (10/2021 - 01/2019)
2.	Wu, Chunfu: 8 articles (10/2021 - 01/2019)
3.	Liu, Yinglu: 5 articles (10/2021 - 01/2019)
4.	Hou, Ying: 4 articles (10/2021 - 10/2019)
5.	Yang, Depeng: 4 articles (10/2021 - 10/2019)
6.	Yuan, Linlin: 4 articles (10/2021 - 01/2019)
7.	Zhang, Haotian: 4 articles (10/2021 - 10/2019)
8.	Liu, Yueyang: 3 articles (10/2021 - 01/2019)
9.	Wang, Pengwei: 3 articles (10/2021 - 10/2019)
10.	Sun, Shibo: 3 articles (01/2020 - 01/2019)

Related Diseases

1.	Ischemic Stroke 01/01/2019 - "Pseudoginsenoside-F11 (PF11), an ocotillol-type ginsenoside with various neuroprotective activities, has displayed therapeutic efficacy against permanent ischemic stroke. " 10/01/2021 - "Pseudoginsenoside-F11 (PF11), an ocotillol-type ginsenoside, has been reported to exert neuroprotective effects on ischemic stroke induced by permanent and transient middle cerebral artery occlusion in experimental animals. " 01/01/2020 - "We previously found that pseudoginsenoside-F11 (PF11), an ocotillol-type saponin, exerts neuroprotective effects against ischemic stroke and neuroinflammation. "
2.	Colitis 08/12/2015 - "These findings suggest that orally administered MR2 may be metabolized to ocotillol in the intestine by gut microbiota and the transformed ocotillol may ameliorate inflammatory diseases such as colitis by restoring the balance of Th17/Treg cells. " 08/12/2015 - "We also examined the anti-inflammatory effect of ocotillol in mice with 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis. " 08/12/2015 - "Ocotillol, a Majonoside R2 Metabolite, Ameliorates 2,4,6-Trinitrobenzenesulfonic Acid-Induced Colitis in Mice by Restoring the Balance of Th17/Treg Cells."
3.	Brain Ischemia (Cerebral Ischemia) 01/01/2021 - "Pseudoginsenoside F11 (PF11), an ocotillol-type saponin, is an important component of Panax quinquefolium which has been shown to confer protection against cerebral ischemia and alleviate oxidative stress. "
4.	Cardiotoxicity 01/01/2014 - "In the current study, the effects of ocotillol on the toxicity of Dox were investigated, particularly its role in cardiotoxicity. " 01/01/2014 - "The results indicate that Dox co‑treatment with ocotillol may effectively alleviate its associated toxic injury, particularly cardiotoxicity. " 01/01/2014 - "We previously reported that ocotillol is capable of enhancing the antitumor activity of Dox; however, the effects of ocotillol on its cardiotoxicity remain unclear. "
5.	Stroke (Strokes) 01/01/2020 - "Our previous study showed that pseudoginsenoside-F11 (PF11), an ocotillol-type saponin, isolated from leaves of Panax pseudoginseng subsp., exerted neuroprotective effects on stroke by alleviating autophagy/lysosomal defects and repressing calcium overload. "

Related Drugs and Biologics

1.	pseudoginsenoside F11 (PF 11)
2.	Saponins
3.	Ginsenosides
4.	Acids
5.	majonoside R2
6.	Neuroprotective Agents
7.	Calcium
8.	Therapeutic Uses
9.	Acetic Acid (Vinegar)
10.	Amino Acids

Related Therapies and Procedures

1.	Resuscitation