Peroxynitrous Acid (Peroxynitrite)

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1265 relevant articles (39 outcomes, 165 trials/studies) found for this Bio-Agent

Description: A potent oxidant synthesized by the cell during its normal metabolism. Peroxynitrite is formed from the reaction of two free radicals, NITRIC OXIDE and the superoxide anion (SUPEROXIDES).

Also Known As:

Peroxynitrite; Peroxonitrite; Peroxynitrous Acid, Potassium Salt; Acid, Peroxynitrous; Acids, Peroxynitrous; Peroxonitrites; Peroxynitrites; Peroxynitrous Acids

Relationship Network

Bio-Agent Context: Research Results

Inorganic Chemicals: 6

Nitrogen Compounds: 37

Reactive Nitrogen Species: 264

Peroxynitrous Acid: 1265

tetramethylammonium peroxynitrite

WW85 compound

Nitrous Acid: 24

Peroxynitrous Acid: 1265

tetramethylammonium peroxynitrite

WW85 compound

Experts

1.	Szabó, Csaba: 7 articles (03/2005 - 07/2002)
2.	Hooper, D C: 6 articles (10/2001 - 04/2000)
3.	Mazzon, Emanuela: 4 articles (09/2008 - 10/2006)
4.	Esposito, Emanuela: 4 articles (09/2008 - 10/2006)
5.	Cuzzocrea, Salvatore: 4 articles (09/2008 - 10/2006)
6.	Di Paola, Rosanna: 4 articles (09/2008 - 10/2006)
7.	Hall, Edward D: 4 articles (06/2008 - 01/2004)
8.	Groves, John T: 4 articles (12/2007 - 10/2002)
9.	Mikheeva, T: 4 articles (10/2001 - 04/2000)
10.	Szabó, C: 4 articles (09/2001 - 03/2001)

Related Diseases

1.	DNA Damage 01/01/2005 - "Peroxynitrite (ONOO-) induces oxidative and nitrosative DNA damage, and previous studies by our group have shown that it is strongly mutagenic in the supF shuttle vector pSP189 replicated in Escherichia coli MBL50 cells. " 02/14/2003 - "The present study was undertaken to test the hypothesis that human SAG protects from DNA damage induced by peroxynitrite, a potent physiological inorganic toxin. " 11/01/2001 - "In conclusion, the present study provides the first attempt to elucidate the role of peroxynitrite in initiation of the cascade of lipid peroxidation and DNA damage to ischemic kidneys. " 10/01/1997 - "The present study suggests that peroxynitrite at lower concentrations (2-5 microM) induces wildtype P53 and apoptosis, which is potentially a protective response toward the DNA damage caused by peroxynitrite. " 01/01/2006 - "The formation of peroxynitrite causes protein oxidation, lipid peroxidation and DNA damage, which ultimately lead to neuronal cell death. " Order ALL the reference details at left...
2.	Reperfusion Injury 01/01/1997 - "Conversely, other studies suggest that NO exacerbates reperfusion injury by inducing the production of peroxynitrite. " 01/01/2008 - "Scavenging of peroxynitrite reduces renal ischemia/reperfusion injury." 07/01/2005 - "The present review overviews the pathophysiological role of the peroxynitrite-PARP pathway in cardiac ischemia/reperfusion injury with special reference to the therapeutic potential of PARP inhibitors in the treatment of this disease." 01/01/2005 - "Its metabolites, nitrite and nitrate, have vasculoprotective properties, whereas peroxynitrite, an oxidant metabolite of NO, is cytotoxic and can aggravate myocardial damage during ischaemic reperfusion injury. " 03/01/2004 - "Hepatoenteric ischemia-reperfusion injury is associated with peroxynitrite (OONO(-)) formation, coagulopathy and decreased TF activity in rabbits. " Order ALL the reference details at left...
3.	Inflammation 02/26/1999 - "Protection against peroxynitrite is important for defense of normal tissue, especially during inflammation. " 06/16/2004 - "OBJECTIVES: The aim of this study was to test whether peroxynitrite neutralizers would reduce peroxynitrite accumulation and improve myocardial contractile dysfunction and inflammation in endotoxin-treated rats. " 06/19/1998 - "Our studies thus provide compelling evidence for the involvement of peroxynitrite in cytokine-mediated cellular injury and suggest the therapeutic potential of PN decomposition catalysts in reducing cellular damage at sites of inflammation." 08/15/2009 - "Peroxynitrite (ONOO(-)/ONOOH) is a potential mediator of such damage, as elevated levels of this oxidant are likely to be present at sites of inflammation. " 05/15/2009 - "SUMMARY OF BACKGROUND DATA: Peroxynitrite is an important tissue-damaging species generated at sites of inflammation and degeneration. " Order ALL the reference details at left...
4.	Ischemia 04/01/2007 - "The use of the peroxynitrite decomposition catalyst (FeTPPS) may help to improve myocardial preservation during a prolonged ischemia sequence." 04/01/1999 - "In the present study we show for the first time a significant decrease of the octamer/dimer ratio in vivo, related to ischemia-induced damage, and a similar decrease of octamer stability in vitro, induced by peroxynitrite (PN) radicals. " 11/01/1997 - "OBJECTIVE: This study examined the effects of peroxynitrite (ONOO-) on cardiac function and cellular injury following ischemia (30 min) and reperfusion (60 min) in isolated perfused rat hearts. " 08/01/2008 - "Lungs were preconditioned by either 5 minutes' ischemia and 5 minutes' reperfusion or 10 microM peroxynitrite prior to 2 hours of normothermic ischemia. " 12/01/2007 - "During ischemia significant increases in NO levels and peroxynitrite signal were observed (from 832.1 +/- 129.3 to 2,928.6 +/- 502.0 nM and from 3.8 +/- 0.7 to 9.0 +/- 1.6 nA before and during ischemia, respectively) that dropped to preischemic levels during reperfusion. " Order ALL the reference details at left...
5.	Shock 01/01/2000 - "Peroxynitrite (OONO-) involves in the development of hyperpolarization in severe shock. " 01/01/2000 - "Peroxynitrite leads to arteriolar smooth muscle cell membrane hyperpolarization and low vasoreactivity in severe shock." 09/25/1995 - "Thus, peroxynitrite is already formed at early stages of shock from ecNOS-derived .NO. Overproduction of .NO by the inducible NOS at late shock was not associated with additional increases in dihydrorhodamine oxidation. " 04/24/1995 - "The demonstration of the in vivo formation of peroxynitrite at sites of .NO overproduction may necessitate the development of novel and additional approaches for limiting or preventing .NO-related cytotoxic or vasodilatory actions during circulatory shock." 04/24/1995 - "Our data suggest that during endotoxin shock, part of .NO, produced following the induction of iNOS, is converted into peroxynitrite in the vicinity of large blood vessels. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Superoxides (Superoxide)
2.	Melatonin
3.	Tyrosine (L-Tyrosine)
4.	manganese(III)-tetrakis(4-benzoic acid)porphyrin
5.	Superoxide Dismutase
6.	Nitric Oxide (Nitrogen Monoxide)
7.	Nitric Oxide Synthase (NO Synthase)
8.	Oxygen
9.	Glutathione (Reduced Glutathione)
10.	Free Radicals

Related Therapies and Procedures

1.	Baths
2.	Transplants (Transplant)
3.	Ligation
4.	Aftercare (After-Treatment)
5.	Warm Ischemia

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