Coronavirus Spike Glycoprotein

A class I viral fusion protein that forms the characteristic spikes, or peplomers, found on the viral surface that mediate virus attachment, fusion, and entry into the host cell. During virus maturation, it is cleaved into two subunits: S1, which binds to receptors in the host cell, and S2, which mediates membrane fusion.

Also Known As:

Spike Glycoprotein, Coronavirus; E2 Spike Glycoprotein, Coronavirus; Glycoprotein S, Coronavirus; Spike Glycoprotein S1, Coronavirus; Spike Protein S2, Coronavirus; Spike Protein, Coronavirus; Coronavirus Spike Protein; Spike Glycoprotein, Bovine Coronavirus; Spike Glycoproteins, Coronavirus

Networked: 25 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Amano, Maho: 1 article (06/2022)
2.	Fujioka, Mari: 1 article (06/2022)
3.	Fujioka, Yoichiro: 1 article (06/2022)
4.	Kashiwagi, Sayaka: 1 article (06/2022)
5.	Ohba, Yusuke: 1 article (06/2022)
6.	Satoh, Aya O: 1 article (06/2022)
7.	Yamauchi, Yohei: 1 article (06/2022)
8.	Yoshida, Aiko: 1 article (06/2022)
9.	Behera, Amrutamaya: 1 article (01/2022)
10.	Das Sarma, Jayasri: 1 article (01/2022)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2021 - "Angiotensin-converting- enzyme 2 (ACE2), the cell surface receptor that recognizes the coronavirus spike protein has protective effects against inflammation and chronic hyperglycemia in animal models. "
2.	Hyperglycemia 01/01/2021 - "Angiotensin-converting- enzyme 2 (ACE2), the cell surface receptor that recognizes the coronavirus spike protein has protective effects against inflammation and chronic hyperglycemia in animal models. "
3.	Infections 01/01/2022 - "Infections are initiated by recognizing host cell receptors by coronavirus spike protein S1 subunit, and then S2 mediates membrane fusion. " 06/25/2022 - "We found that a large proportion of pseudovirions produced with the conventional transient expression system lacked coronavirus spike protein at their surface as a result of inhibition of parental VSV infection by overexpression of this protein. " 01/01/2021 - "Antibodies against coronavirus spike protein potently protect against infection and disease, but whether such protection can be extended to variant coronaviruses is unclear. " 10/01/2016 - "We report here the 3.4-Å-resolution cryo-EM reconstruction of the HCoV-NL63 coronavirus spike glycoprotein trimer, which mediates entry into host cells and is the main target of neutralizing antibodies during infection. " 01/01/2023 - "Coronavirus spike protein-specific antibodies indicate frequent infections and reinfections in infancy and among BNT162b2-vaccinated healthcare workers."
4.	COVID-19 02/24/2023 - "Significance of Conserved Regions in Coronavirus Spike Protein for Developing a Novel Vaccine against SARS-CoV-2 Infection." 01/01/2021 - "Especially, in COVID-19 patients, the overactivation of NF-kΒ, which is caused by the binding of coronavirus spike protein S to alveolar epithelial cells, up-regulates IL-6 and promotes its systematic circulation, causing alveolar damage and extrapulmonary injury. " 03/01/2023 - "Coronavirus spike glycoprotein (GP)-Receptor Binding Domain (RBD) and its interaction with host receptor angiotensin converting enzyme 2 (ACE2) is one of the most structurally understood but therapeutically untapped aspect of COVID-19 pathogenesis. " 07/19/2022 - "Human Coronavirus Spike Protein Based Multi-Epitope Vaccine against COVID-19 and Potential Future Zoonotic Coronaviruses by Using Immunoinformatic Approaches." 10/16/2020 - "COVID-19 and iron dysregulation: distant sequence similarity between hepcidin and the novel coronavirus spike glycoprotein."
5.	Bronchitis 10/22/2019 - "The S2 Subunit of QX-type Infectious Bronchitis Coronavirus Spike Protein Is an Essential Determinant of Neurotropism." 01/01/2018 - "Cryo-EM structure of infectious bronchitis coronavirus spike protein reveals structural and functional evolution of coronavirus spike proteins." 07/01/1987 - "285 longer than the avian infectious bronchitis coronavirus spike protein); partial N-terminal sequencing demonstrated that a putative secretory signal sequence of 16 amino acids is absent in the virion-associated protein; the predicted mol. "

Related Drugs and Biologics

1.	Cell Surface Receptors
2.	Angiotensin-Converting Enzyme 2
3.	Proteins (Proteins, Gene)
4.	Vaccines
5.	Angiotensin Receptors (Angiotensin II Receptor)
6.	Peptides (Polypeptides)
7.	Enzymes
8.	Antibodies
9.	Amino Acids
10.	Hepcidins