Artificial Receptors

Receptors that are created by SYNTHETIC CHEMISTRY TECHNIQUES. They are usually designed to mimic endogenous CELL SURFACE RECEPTORS.

Also Known As:

Receptors, Artificial; Abiotic Receptors; Biocompatible Artificial Receptors; Biocompatible Synthetic Receptors; Synthetic Receptors; Abiotic Receptor; Artificial Receptor; Artificial Receptor, Biocompatible; Artificial Receptors, Biocompatible; Biocompatible Artificial Receptor; Biocompatible Synthetic Receptor; Receptor, Abiotic; Receptor, Artificial; Receptor, Biocompatible Artificial; Receptor, Biocompatible Synthetic; Receptor, Synthetic; Receptors, Abiotic; Receptors, Biocompatible Artificial; Receptors, Biocompatible Synthetic; Receptors, Synthetic; Synthetic Receptor; Synthetic Receptor, Biocompatible; Synthetic Receptors, Biocompatible

Networked: 86 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wang, Ruibing: 5 articles (01/2019 - 10/2017)
2.	Fraietta, Joseph A: 3 articles (01/2022 - 01/2018)
3.	Lee, Simon M Y: 3 articles (09/2018 - 10/2017)
4.	Nethi, Susheel Kumar: 2 articles (03/2021 - 04/2020)
5.	Prabha, Swayam: 2 articles (03/2021 - 04/2020)
6.	Safarzadeh Kozani, Pooria: 2 articles (01/2021 - 10/2020)
7.	Safarzadeh Kozani, Pouya: 2 articles (01/2021 - 10/2020)
8.	Tan, Weihong: 2 articles (12/2020 - 11/2019)
9.	Sun, Jie: 2 articles (12/2019 - 12/2015)
10.	Li, Lanlan: 2 articles (01/2019 - 01/2019)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2014 - "Preliminary studies on application of library of artificial receptors for differentiation of metabolites in urine of healthy and cancer bearing mice." 10/25/2023 - "Synthetic Receptors for Early Detection and Treatment of Cancer." 06/01/2023 - "Building bioorthogonal click-release capable artificial receptors on cancer cell surface for imaging, drug targeting and delivery." 01/01/2022 - "CAR-T cell therapy relies on immune cells being modified to express an artificial receptor targeting cancer-specific markers, and infused into the patients where they will recognize and eliminate the tumour. " 03/31/2021 - "Briefly, artificial receptors are first anchored on the cell plasma membrane using cell-labeling agents (Az-NPs) via the enhanced permeability and retention effect to achieve the tumor cell labeling. "
2.	Persistent Infection 08/01/2015 - "ACT of T cells engineered to express artificial receptors that target cells of choice is an exciting new approach for cancer, and it holds equal promise for chronic infection and autoimmunity. "
3.	Cardiotoxicity 09/01/2018 - "Cardiovascular studies using an in vivo zebrafish model demonstrated that the cardiotoxicity of BDQ was indeed alleviated upon its complexations by the synthetic receptor. " 09/01/2018 - "In this present study, we have explored into employing host-guest interactions between a synthetic receptor, cucurbit[7]uril (CB[7]), and BDQ aiming to improve the solubility and reduce the inherent cardiotoxicity of BDQ. " 10/04/2017 - "Herein we report that the encapsulation of SO by a synthetic receptor cucurbit[7]uril (CB[7]) alleviated the inherent cardiotoxicity of SO, as demonstrated in an in vivo zebrafish model. " 01/01/2018 - "This is the first time that cucurbit[7]uril and cucurbit[8]uril have been demonstrated to serve as synthetic receptors for a halonium guest species, diphenyleneiodonium, modulating its bioactivities and alleviating its cardiotoxicity, which further expands the onium family of guest molecules for the cucurbit[ n]uril family and provides new insights for halonium-cucurbit[ n]uril host-guest chemistry and its potential applications in pharmaceutical chemistry."
4.	Hematologic Neoplasms (Hematological Malignancy) 01/01/2021 - "T cells engineered with synthetic receptors have delivered powerful therapeutic results for patients with relapsed/refractory hematologic malignancies. " 01/01/2017 - "CARs are synthetic receptors that enhance T-cell antitumor effector function and have gained momentum to investigate in solid tumors based on recent successes of clinical trials treating patients with B-cell hematologic malignancies. " 12/25/2019 - "Chimeric antigen receptor T (CAR-T) cell therapy, which adoptively transfers engineered T cells expressing synthetic receptors to target specific antigens, has achieved great clinical success in treating hematological malignancies. "
5.	Infections 08/01/2006 - "We used artificial receptors for the virus to develop serologic assays to detect dengue virus infection. " 08/01/2006 - "Artificial receptors in serologic tests for the early diagnosis of dengue virus infection." 08/01/2005 - "These artificial receptors protected HeLa cells against infection with human rhinovirus serotype 2 (HRV2) to a degree that strongly increased with the number of repeats present; maximal protection was seen for the pentameric concatemer (MBP-V33333). " 01/01/1992 - "Technical possibilities are rapidly developing for the design of synthetic receptor analogues to be used in the therapy of clinical infections. " 01/01/1997 - "By reconstitution experiments, using bovine brain gangliosides as artificial receptors, the degree of super-infection was markedly increased. "

Related Drugs and Biologics

1.	Antigens
2.	Chimeric Antigen Receptors
3.	cucurbit(7)uril
4.	Peptides (Polypeptides)
5.	Ligands
6.	Surface Antigens (Surface Antigen)
7.	Neoplasm Antigens (Tumor Antigens)
8.	Biomarkers (Surrogate Marker)
9.	Proteins (Proteins, Gene)
10.	Polysaccharides (Glycans)

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Radiotherapy
4.	Microspheres (Microsphere)
5.	Drug Therapy (Chemotherapy)