Supramolecular Encapsulation and Bioactivity Modulation of a Halonium Ion by Cucurbit[ n]uril ( n = 7, 8).

Abstract	This is the first time that cucurbit[7]uril and cucurbit[8]uril have been demonstrated to serve as synthetic receptors for a halonium guest species, diphenyleneiodonium, modulating its bioactivities and alleviating its cardiotoxicity, which further expands the onium family of guest molecules for the cucurbit[ n]uril family and provides new insights for halonium-cucurbit[ n]uril host-guest chemistry and its potential applications in pharmaceutical chemistry.
Authors	Hang Yin, Qiaoxian Huang, Wenwen Zhao, David Bardelang, Didier Siri, Xiuping Chen, Simon M Y Lee, Ruibing Wang
Journal	The Journal of organic chemistry (J Org Chem) Vol. 83 Issue 8 Pg. 4882-4887 (04 20 2018) ISSN: 1520-6904 [Electronic] United States
PMID	29616817 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Bridged-Ring Compounds Capsules Cardiotonic Agents Halogens Imidazoles cucurbit(7)uril cucurbit(8)uril
Topics	Animals Bridged-Ring Compounds (chemistry, pharmacology) Capsules Cardiotonic Agents (chemistry, pharmacology) Dose-Response Relationship, Drug Halogens (chemistry) Heart (drug effects) Imidazoles (chemistry, pharmacology) Mice RAW 264.7 Cells Structure-Activity Relationship Zebrafish

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