Secretory Proteinase Inhibitory Proteins

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15 relevant articles (1 outcomes, 0 trials/studies) found for this Bio-Agent

Description: Peptides and proteins found in BODILY SECRETIONS and BODY FLUIDS that are PROTEASE INHIBITORS. They play a role in INFLAMMATION, tissue repair and innate immunity (IMMUNITY, INNATE) by inhibiting endogenous proteinases such as those produced by LEUKOCYTES and exogenous proteases such as those produced by invading microorganisms.

Also Known As:

Proteinase Inhibitory Proteins, Secretory; Peptidase Inhibitory Peptides, Secretory; Peptidase Inhibitory Proteins, Secretory; Protease Inhibitory Peptides, Secretory; Protease Inhibitory Proteins, Secretory; Elastase Inhibitors, Neutrophil; Inhibitors, Neutrophil Elastase; Neutrophil Elastase Inhibitors; Proteinase Inhibitory Peptides, Secretory

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Bio-Agent Context: Research Results

Experts

1.	Ohbayashi, Hiroyuki: 2 articles (09/2002 - 07/2002)
2.	Zeiher, Bernhardt G: 1 article (05/2002)
3.	Repine, John E: 1 article (05/2002)
4.	Kawabata, Kazuhito: 1 article (05/2002)
5.	Matsuoka, Shozo: 1 article (05/2002)

Related Diseases

1.	Idiopathic Interstitial Pneumonias 09/01/1999 - "Neutrophil elastase inhibitors become very useful therapeutic agents against acute exacerbation of idiopathic interstitial pneumonia (IIP), because this pathological conditions is a type of ALI. " 12/01/1996 - "Neutrophil elastase inhibitors may become important as therapeutic agents against acute exacerbations of idiopathic interstitial pneumonia, because this pathological condition is a type of acute lung injury. " Order ALL the reference details at left...
2.	Acute Lung Injury 12/01/1996 - "Neutrophil elastase inhibitors may become important as therapeutic agents against acute exacerbations of idiopathic interstitial pneumonia, because this pathological condition is a type of acute lung injury. " 06/01/1993 - "These data suggest the need for further research examining the role of protease-antiprotease interactions and the potential utility of neutrophil elastase inhibitors in acute lung injury like that observed in the adult respiratory distress syndrome (ARDS) in the human." 05/01/2002 - "Neutrophil elastase and acute lung injury: prospects for sivelestat and other neutrophil elastase inhibitors as therapeutics." Order ALL the reference details at left...
3.	Chronic Obstructive Pulmonary Disease (COPD) 07/01/2002 - "Neutrophil elastase inhibitors as treatment for COPD." 08/01/2002 - "ONO-6818 (CP-955) is the lead compound in a series of orally bioavailable neutrophil elastase inhibitors licensed from Cortech and under investigation by Ono for the potential treatment of inflammatory conditions, such as rheumatoid arthritis, inflammatory bowel disease and chronic obstructive pulmonary disease (COPD) [174095]. " 05/01/2006 - "Tyrosine kinase antagonists, inhibitors of NF-kappaB, neutrophil elastase inhibitors, chemokine antagonists, mucolytics and novel antibiotics are being evaluated for possible effectiveness in COPD. " 07/01/2002 - "In the application of chronic obstructive pulmonary disease therapy, the human neutrophil elastase inhibitors mainly focused upon include ONO-5046, MR-889, L-694,458, CE-1037, GW-311616 and TEI-8362 as the acyl-enzyme inhibitors; and ONO-6818, AE-3763, FK-706, ICI-200,880, ZD-0892 and ZD-8321 as the transition-state inhibitors. " Order ALL the reference details at left...
4.	Lung Diseases (Lung Disease) 09/01/2002 - "Novel neutrophil elastase inhibitors as a treatment for neutrophil-predominant inflammatory lung diseases." 03/01/2002 - "The naturally occurring neutrophil elastase inhibitors, alpha1-proteinase inhibitor (alpha1PI), secretory leukocyte proteinase inhibitor (SLPI), and elafin, are potential therapeutic agents in the treatment of neutrophil-mediated lung disease. " Order ALL the reference details at left...
5.	Lung Injury 04/01/2003 - "This article reviews some of the physiologic actions of proteases, specifically elastase, the evidence for neutrophil elastase involvement in ARDS, and the potential therapeutic use of neutrophil elastase inhibitors in lung injury. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Leukocyte Elastase (Neutrophil Elastase)
2.	ONO 5046 (sivelestat)
3.	ONO 6818
4.	Elafin
5.	P-Selectin
6.	NF-kappa B (NF-kB)
7.	Trypsin
8.	Taurocholic Acid (Sodium Taurocholate)
9.	Sodium
10.	Protein-Tyrosine Kinases (Tyrosine Kinase)

Related Therapies and Procedures

1.	Therapeutics

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