Interleukin 1 Receptor Antagonist Protein (Anakinra)

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991 relevant articles (82 outcomes, 158 trials/studies) found for this Drug

Description: A ligand that binds to but fails to activate the INTERLEUKIN-1 RECEPTOR. It plays an inhibitory role in the regulation of INFLAMMATION and FEVER. Several isoforms of the protein exist due to multiple ALTERNATIVE SPLICING of its mRNA.

Also Known As:

Anakinra; Kineret; IL-1Ra; Amgen Brand of Anakinra; Antril; IL-1 Inhibitor, Urine; IL1 Febrile Inhibitor; Interleukin 1 Inhibitor, Urine; Synergen Brand of Anakinra; Urine-Derived IL1 Inhibitor; Anakinra Amgen Brand; Anakinra Synergen Brand; Febrile Inhibitor, IL1; IL 1 Inhibitor, Urine; IL1 Inhibitor, Urine-Derived; Urine Derived IL1 Inhibitor; Urine IL-1 Inhibitor

Relationship Network

Drug Context: Research Results

Amino Acids, Peptides, and Proteins

Proteins: 56522

Intercellular Signaling Peptides and Proteins: 9149

Cytokines: 32925

Interleukin 1 Receptor Antagonist Protein: 991

human IL1RN protein

mouse Il1rn protein

Peptides: 16074

Intercellular Signaling Peptides and Proteins: 9149

Cytokines: 32925

Interleukin 1 Receptor Antagonist Protein: 991

human IL1RN protein

mouse Il1rn protein

Biological Factors: 868

Intercellular Signaling Peptides and Proteins: 9149

Cytokines: 32925

Interleukin 1 Receptor Antagonist Protein: 991

human IL1RN protein

mouse Il1rn protein

Experts

1.	Fleischmann, Roy: 4 articles (04/2007 - 04/2004)
2.	Liossis, Stamatis-Nick C: 3 articles (03/2008 - 04/2005)
3.	Emery, P: 3 articles (02/2008 - 09/2004)
4.	McDermott, Michael F: 3 articles (02/2008 - 02/2004)
5.	Tan, A L: 3 articles (02/2008 - 09/2004)
6.	McGonagle, D: 3 articles (02/2008 - 09/2004)
7.	Schiff, Michael H: 3 articles (01/2005 - 01/2004)
8.	Tesser, John: 3 articles (06/2004 - 04/2003)
9.	Schechtman, Joy: 3 articles (06/2004 - 04/2003)
10.	Bresnihan, B: 3 articles (05/2003 - 09/2002)

Related Diseases

1.	Rheumatoid Arthritis 01/01/2007 - "CONCLUSIONS: Our clinical experience confirms that anakinra is effective and safe in the treatment of rheumatoid arthritis" 05/01/2004 - "article reviews the preclinical, clinical, and postmarketing data on the safety and efficacy of anakinra in the treatment of rheumatoid arthritis and focuses on the pivotal clinical trials that led to FDA approval." 09/01/2002 - "A large, prospective safety study which allowed a wide-variety of comorbid conditions and concomitant medications demonstrated that anakinra therapy is a well-tolerated treatment for rheumatoid arthritis in the patient population seen by the practicing rheumatologist" 07/01/2002 - "Anakinra shows promise for treating patients with rheumatoid arthritis." 05/20/2008 - "METHODS AND RESULTS: In an acute, double-blind trial, 23 patients with rheumatoid arthritis were randomized to receive a single injection of anakinra (150 mg s.c.) or placebo and, after 48 hours, the alternative treatment" Get all the results and reference details, order at left...
2.	Syndrome 04/01/2006 - "CONCLUSION: Anakinra proved to be effective in three patients with Schnitzler's syndrome" 12/01/2006 - "Anakinra is safe and effective in controlling hyperimmunoglobulinaemia D syndrome-associated febrile crisis." 12/01/2007 - "Lasting remission of a Muckle-Wells syndrome with CIAS-1 mutation using half-dose anakinra." 05/01/2005 - "Dramatic improvement with anakinra in a case of chronic infantile neurological cutaneous and articular (CINCA) syndrome." 11/01/2008 - "A case of macrophage activation syndrome successfully treated with anakinra." Get all the results and reference details, order at left...
3.	Inflammation 07/01/2002 - "IL-1Ra and vIL-10 gene transfer using retroviral vectors ameliorates particle-associated inflammation in the murine air pouch model." 06/01/2008 - "The aim of our study was to characterize effects and mechanisms of IL-1ra administration on inflammation, apoptosis, and infiltration in renal I/R injury" 09/01/2001 - "Our study demonstrates a decreased production of the anti-inflammatory compound IL-1ra, suggesting a propensity towards inflammation in patients with AD." 08/01/2000 - "IL-1ra has proved its therapeutic value in RA, but with the dose schedule in this study it does not behave as a specific radiopharmaceutical that is suitable for scintigraphic detection of inflammation." 03/01/1998 - "The results of these studies indicate that distal airway epithelial cell expression of human IL-1ra results in partial protection from IL-1alpha-induced airway inflammation and injury." Get all the results and reference details, order at left...
4.	Arthritis (Polyarthritis) 02/01/2000 - "CONCLUSION: This gene therapy, by combining highly efficient and stable rAAV gene delivery, disease-regulated gene expression, and the antiinflammatory effect of IL-1Ra, provides a valuable approach for long-term protection against, and prevention of, arthritis." 12/01/2005 - "However despite its rather disappointing effect in polyarticular arthritis, anakinra is being discovered as an effective treatment of systemic arthritis and children with mutations in the NALP3/CIAS1/PYPAF1 genes leading to autoimmune inflammatory disorders such as neonatal- onset multisystem inflammatory disease." 01/01/2003 - "Daily bolus injections of IL-1Ra may therefore be useful for protection against joint damage following minor joint injury, whereas the maintenance of appropriate blood levels of the antagonist may be critical for its therapeutic effect on chronic inflammatory arthritis." 01/01/2003 - "CONCLUSION: Daily administration of recombinant IL-1Ra, injected at the same time as arthritis induction, is effective in blocking the occurrence of inflammatory as well as destructive changes in CIA" 01/01/2001 - "Recombinant human IL-1Ra (rhu-IL-1Ra) has been evaluated in RA in several randomised clinical trials and was shown to significantly reduce both the clinical manifestations of arthritis and the rate of progressive joint damage" Get all the results and reference details, order at left...
5.	Adult-Onset Still's Disease 05/01/2008 - "Effective treatment of steroid refractory adult-onset Still's disease with anakinra." 06/01/2007 - "Anakinra treatment in patients with adult-onset Still's disease is fast, effective, safe and steroid sparing: experience from an uncontrolled trial." 12/01/2007 - "Anakinra in patients with treatment-resistant adult-onset Still's disease: four case reports with serial cytokine measurements and a review of the literature." 06/01/2005 - "Rapid responses to anakinra in patients with refractory adult-onset Still's disease." 04/01/2005 - "Refractory adult onset Still's disease successfully treated with anakinra." Get all the results and reference details, order at left...
354 Diseases and 991 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

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5.	Methotrexate (Mexate)
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8.	Interleukin 1 Receptor Antagonist Protein (Anakinra)
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10.	adalimumab (Humira)
712 Drugs and Important Bio-Agents and 668 more articles analyzed in the Research Interface, order at left...

Related Therapies and Procedures

1.	Stents
2.	Aftercare (After-Treatment)
3.	Kidney Transplantation
4.	Renal Dialysis (Hemodialysis)
5.	Immunotherapy
30 Therapies and Procedures and 45 more articles analyzed in the Research Interface, order at left...

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