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Tissue Inhibitor of Metalloproteinases

A family of secreted protease inhibitory proteins that regulates the activity of SECRETED MATRIX METALLOENDOPEPTIDASES. They play an important role in modulating the proteolysis of EXTRACELLULAR MATRIX, most notably during tissue remodeling and inflammatory processes.
Also Known As:
TIMP Proteins; Metalloproteinase Tissue Inhibitor; Metalloproteinases Tissue Inhibitor; Proteins, TIMP; Tissue Inhibitor of Metalloproteinase
Networked: 855 relevant articles (13 outcomes, 120 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Kellum, John A: 8 articles (10/2021 - 04/2014)
2. Tyagi, Suresh C: 7 articles (01/2017 - 09/2003)
3. Brünner, Nils: 7 articles (04/2015 - 01/2002)
4. Brünner, N: 7 articles (01/2009 - 11/2000)
5. Nielsen, H J: 7 articles (01/2009 - 11/2000)
6. Kassiri, Zamaneh: 6 articles (10/2018 - 08/2010)
7. Spinale, Francis G: 6 articles (10/2017 - 03/2005)
8. Edwards, Dylan R: 6 articles (05/2011 - 12/2003)
9. Khokha, Rama: 5 articles (11/2021 - 01/2010)
10. Sorsa, Timo: 5 articles (01/2019 - 02/2008)

Related Diseases

1. Neoplasms (Cancer)
2. Neoplasm Metastasis (Metastasis)
3. Fibrosis (Cirrhosis)
4. Breast Neoplasms (Breast Cancer)
5. Wounds and Injuries (Trauma)

Related Drugs and Biologics

1. Matrix Metalloproteinases (MMPs)
2. Tissue Inhibitor of Metalloproteinase-2
3. Messenger RNA (mRNA)
4. Proteins (Proteins, Gene)
5. Collagen
6. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
7. Transforming Growth Factors (Transforming Growth Factor)
8. Collagenases (Collagenase)
9. Collagen Type III (Type III Collagen)
10. Intercellular Signaling Peptides and Proteins (Growth Factors)

Related Therapies and Procedures

1. Oral Administration
2. Percutaneous Coronary Intervention
3. Stents
4. Transplantation
5. Lasers (Laser)