|1.||Gleave, Martin E: 37 articles (04/2014 - 02/2002)|
|2.||Gleave, Martin: 22 articles (11/2015 - 01/2002)|
|3.||Miyake, Hideaki: 20 articles (12/2014 - 01/2002)|
|4.||Bettuzzi, Saverio: 16 articles (01/2015 - 06/2002)|
|5.||Hara, Isao: 14 articles (09/2006 - 01/2002)|
|6.||Zoubeidi, Amina: 12 articles (09/2014 - 08/2008)|
|7.||Beraldi, Eliana: 9 articles (11/2015 - 03/2004)|
|8.||Fazli, Ladan: 9 articles (11/2015 - 03/2004)|
|9.||Chi, Kim N: 9 articles (08/2013 - 06/2004)|
|10.||Xie, Dan: 9 articles (05/2013 - 01/2005)|
04/01/2011 - "Because increased clusterin expression correlates with aggressive behavior in tumors, clusterin inhibition might be beneficial in cancer treatment. "
07/21/2015 - "Custirsen (OGX-011) is a novel 2'-methoxyethyl modified phosphorothioate antisense oligonucleotide that targets secretory clusterin protein expression and is currently in clinical trials for patients with different cancers. "
11/01/2009 - "This study highlights the potential of clusterin detection in stool to be a valuable tool to improve the effectiveness and efficiency of large-scale clinical cancer screening."
11/01/2009 - "Secreted clusterin isoform (sCLU) is cytoprotective and its prosurvival function is the basis of the current phase I/II clinical trials against prostate, lung, and breast cancers. "
08/01/2009 - "This study seeks to further characterize the immunophenotype of these tumors, and investigates the utility of clusterin as a diagnostic marker. "
|2.||Prostatic Neoplasms (Prostate Cancer)
10/01/2008 - "Further studies revealed that clusterin is methylated in the TRAMP-C2 cell line, as well as in the human prostate cancer cell line LNCaP. "
09/01/2005 - "The objective of this study was to review our experience in the development of antisense (AS) oligodeoxynucleotide (ODN) therapy for prostate cancer targeting antiapoptotic gene, clusterin. "
02/01/2005 - "Our recent studies showed that antisense oligodeoxynucleotide targeting antiapoptotic gene, clusterin, enhanced apoptosis induced by conventional therapeutic modalities using several prostate cancer models. "
12/01/2004 - "In the present study, we investigated the effect of oxidative stress on cell injury using androgen-dependent human prostate cancer LNCaP cells overexpressing clusterin, which has been shown to play crucial roles in the acquisition of resistance to several apoptotic stimuli. "
01/01/2004 - "Results of this preliminary study support the important role of clusterin in the stromal component for prostate cancer progression. "
|3.||Neoplasm Metastasis (Metastasis)
11/01/2014 - "Clusterin expression in gastrointestinal neuroendocrine tumours is highly correlated with location and is helpful in determining the origin of liver metastases."
09/01/2012 - "The aim of this study is to evaluate clusterin as a marker for evaluating diagnosis and metastasis potential of viral-related HCC. "
10/27/2015 - "Here, we identified the clusterin (CLU) gene that is also enriched in Lgr5+ intestinal stem cells, as a gene induced during L1-mediated CRC metastasis. "
11/01/2014 - "Clusterin expression in gastrointestinal NETs is highly correlated with location and probably also with grading, in both the primary tumour and metastases. "
09/01/2012 - "Clusterin might be deemed as a useful marker for predicting the progression and metastasis potential of HCC."
|4.||Urinary Bladder Neoplasms (Bladder Cancer)
02/01/2005 - "Therapeutic efficacy of adenoviral-mediated p53 gene transfer is synergistically enhanced by combined use of antisense oligodeoxynucleotide targeting clusterin gene in a human bladder cancer model."
02/01/2005 - "These findings suggest that combined treatment with AS clusterin ODN and Ad5CMV-p53 could be a novel strategy to inhibit bladder cancer progression, and that further additional use of a chemotherapeutic agent may substantially enhance the efficacy of this combined regimen."
06/01/2005 - "This study was to analyze correlation of expression of clusterin protein to clinicopathologic parameters and prognosis of bladder cancer with tissue chip. "
05/01/2005 - "The objective of this study was to investigate whether radiation sensitivity was enhanced by suppressing clusterin gene expression with antisense (AS) oligodeoxynucleotide (ODN) in the human bladder cancer KoTCC-1 model. "
12/01/2001 - "Although recent studies have demonstrated a protective role of clusterin expression against various kinds of apoptotic stimuli, the functional role of clusterin in the acquisition of a therapy-resistant phenotype in bladder cancer remains unknown. "
|5.||Lung Neoplasms (Lung Cancer)
11/15/2005 - "The purpose of this study was to determine whether inhibition of clusterin by an antisense-based investigative drug enhances radiation sensitization in a lung cancer model. "
03/01/2013 - "Clusterin expression may change in various human malignancies, including lung cancer. "
01/01/2009 - "Clusterin (CLU) and lung cancer."
11/15/2005 - "Clusterin as a therapeutic target for radiation sensitization in a lung cancer model."
03/01/2004 - "These findings identify clusterin as a valid therapeutic target in strategies employing novel multimodality therapy for advanced lung cancer."
|3.||Apolipoproteins E (ApoE)
|1.||Drug Therapy (Chemotherapy)
|2.||Heterologous Transplantation (Xenotransplantation)