Complement C1r (Complement Component 1r)
A 80-kDa subcomponent of complement C1, existing as a SERINE PROTEASE proenzyme in the intact complement C1 complex. When COMPLEMENT C1Q is bound to antibodies, the changed tertiary structure causes autolytic activation of complement C1r which is cleaved into two chains, A (heavy) and B (light, the serine protease), connected by disulfide bonds. The activated C1r serine protease, in turn, activates COMPLEMENT C1S proenzyme by cleaving the Arg426-Ile427 bond. No fragment is released when either C1r or C1s is cleaved.
Also Known As:
Complement Component 1r; C1r Complement; Complement 1r; C1r, Complement; Complement, C1r; Component 1r, Complement
Networked: 18
relevant articles (0 outcomes,
4 trials/studies)
Bio-Agent Context: Research Results
Experts
1. | Portilla, Didier:
2 articles
(01/2021 - 11/2019)
|
2. | Xavier, Sandhya:
2 articles
(01/2021 - 11/2019)
|
3. | Mitaki, Shingo:
1 article
(12/2021)
|
4. | Nagai, Atsushi:
1 article
(12/2021)
|
5. | Sheikh, Abdullah Md:
1 article
(12/2021)
|
6. | Wada, Yasuko:
1 article
(12/2021)
|
7. | Yamaguchi, Shuhei:
1 article
(12/2021)
|
8. | Cheng, Shuai:
1 article
(01/2021)
|
9. | Wang, Chuan-Hui:
1 article
(01/2021)
|
10. | Wang, Fa-Kai:
1 article
(01/2021)
|
Related Diseases
1. | Pulmonary Embolism
|
2. | Neoplasm Metastasis (Metastasis)
|
3. | Ischemic Stroke
12/15/2021
- " Of the 29 proteins identified, alpha-2-macroglobulin, complement C1q subcomponent subunit B, complement C1r subcomponent, and histidine-rich glycoprotein were significantly upregulated (2.21-, 2.15-, 2.24-, and 2.16-fold, respectively) in subjects with future ischemic stroke, as compared with controls. " 06/03/2008
- " This study investigates the potential application of plasma SCUBE1 [signal peptide-CUB (complement C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor)-like domain-containing protein 1] as a biomarker of platelet activation in acute coronary syndrome (ACS) and acute ischemic stroke (AIS). "
|
4. | Acute Coronary Syndrome
|
5. | Lung Neoplasms (Lung Cancer)
|
|
Related Drugs and Biologics
Related Therapies and Procedures