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Pyrroles

Azoles of one NITROGEN and two double bonds that have aromatic chemical properties.
Also Known As:
Pyrrole; 1-aza-2,4-cyclopentadiene
Networked: 369 relevant articles (18 outcomes, 41 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Nagase, Hiroki: 15 articles (04/2022 - 03/2010)
2. Fukuda, Noboru: 12 articles (04/2021 - 03/2010)
3. Dervan, Peter B: 11 articles (01/2017 - 11/2004)
4. Watanabe, Takayoshi: 10 articles (04/2022 - 03/2010)
5. Sugiyama, Hiroshi: 9 articles (01/2021 - 01/2006)
6. Fujiwara, Kyoko: 7 articles (06/2020 - 11/2013)
7. Soma, Masayoshi: 7 articles (06/2020 - 11/2013)
8. Koshikawa, Nobuko: 6 articles (04/2022 - 01/2014)
9. Lin, Jason: 5 articles (04/2022 - 01/2016)
10. Shinozaki, Yoshinao: 5 articles (04/2022 - 01/2016)

Related Diseases

1. Neoplasms (Cancer)
01/01/2017 - "Among the synthesized compounds, specially the compounds bearing 3,4-dimethoxy phenyl at the 4th position of the pyrrole ring showed potent anti-cancer activity, cpd 19 was the most potent against MGC 80-3, HCT-116 and CHO cell lines (IC50s = 1.0-1.7 μM), cpd 21 was the most potent against HepG2, DU145 and CT-26 cell lines (IC50s = 0.5-0.9 μM), and cpd 15 was the most potent against A549 (IC50 = 3.6 μM). "
12/24/2020 - "Based on previously developed inhibitors, we have optimized a small series of 4-acyl pyrroles, which we further analyzed by ITC, X-ray crystallography, selectivity studies, the NCI60 cell-panel, and GI50 determinations for several cancer cell lines. "
01/01/2017 - "The study of the structure-activity relationships revealed that the introduction of the electron-donation groups at the 4th position of the pyrrole ring increased the anti-cancer activity. "
01/01/2013 - "By NMR, structure-activity relationship study, and site-directed mutation, compound 6d (3-(4-aminophenylthio)-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-3-phenyl)propylamine) was identified to span p2-p4 pockets of Mcl-1, Bcl-2 and Bcl-x(L), and then exhibited 9- to 35-fold better affinity to the three targets than 3 (IC(50)=10, 20 and 18 nM, respectively), which led to greater activity in induction of apoptosis in multiple cancer cell lines. "
01/01/2021 - "We used immunohistochemistry to analyze the expression of PD-1, PD-L1, indoleamine-pyrrole 2,3-dioxygenase (IDO), and CD163 (a marker of tumor-associated macrophages [TAMs]) in metastatic tumors. "
2. Carcinoma (Carcinomatosis)
3. Melanoma (Melanoma, Malignant)
4. Breast Neoplasms (Breast Cancer)
5. Ehrlich Tumor Carcinoma

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4. Lasers (Laser)
5. Electrodes (Electrode)