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TWS 119

antineoplastic agent; structure in first source

Also Known As:

TWS-119; TWS119

Networked: 12 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - TWS 119: 12
  - Pyrimidines: 510
    - TWS 119: 12

Experts

1.	Chen, Qianxue: 2 articles (01/2017 - 12/2016)
2.	Li, Mingchang: 2 articles (01/2017 - 12/2016)
3.	Wang, Jian: 2 articles (01/2017 - 12/2016)
4.	Wang, Wei: 2 articles (01/2017 - 12/2016)
5.	Wang, Yuefei: 2 articles (01/2017 - 12/2016)
6.	Jiang, Cheng-Wei: 1 article (05/2022)
7.	Sun, Guang: 1 article (05/2022)
8.	Yang, Zhao-Ying: 1 article (05/2022)
9.	Zhang, Wen-Long: 1 article (05/2022)
10.	Berman, Alexys R: 1 article (01/2022)

Related Diseases

1.	Colonic Neoplasms (Colon Cancer) 01/01/2018 - "Wnt pathway activator TWS119 enhances the proliferation and cytolytic activity of human γδT cells against colon cancer." 01/01/2018 - "Our results also showed that enhancement of the cytolytic activity of γδT cells against human colon cancer cells by TWS119 was chiefly associated with upregulation of the expression of perforin and granzyme B in vitro and in vivo. " 01/01/2018 - "In this study, we sought to evaluate whether the activation of the wnt/β-catenin pathway through inhibition of glycogen synthase kinase-3β (GSK-3β) using 4,6-disubstituted pyrrolopyrimidine (TWS119) could be an efficient strategy to improve the proliferation, differentiation and cytolytic activity of γδT cells against colon cancer cells. " 01/01/2016 - "We measured expression of GOLPH3 mRNA in the human colon cancer cell lines HCT116, HT29, SW480 and SW620 by RT-PCR, and the cells with the highest expression were selected and divided into four groups: negative control, GOLPH3 siRNA transfection (siRNA-GOLPH3), Akt inhibitor (Tricinbine), and glycogen synthase kinase (GSK)-3β inhibitor (TWS119). "
2.	Infarction (Infarctions) 12/06/2019 - "TWS119 mitigated neurological deficits at days 14 and 21 after experimental stroke, paralleled by acceleration on angiogenesis and neural plasticity in the peri-infarct cortex. " 01/01/2017 - "TWS119 treatment reduced neurologic deficits, brain edema, infarct volume, and blood-brain barrier permeability compared with those in the vehicle group. "
3.	Ischemic Stroke 12/01/2016 - "Sprague-Dawley rats were subjected to a middle cerebral artery occlusion (MCAO) model of ischemic stroke and then were administered rtPA, rtPA combined with TWS119, or vehicle at 4 h. " 12/01/2016 - "GSK-3β inhibitor TWS119 attenuates rtPA-induced hemorrhagic transformation and activates the Wnt/β-catenin signaling pathway after acute ischemic stroke in rats." 12/06/2019 - "Mechanistically, cerebral ischemia induced production of microglia-associated proinflammatory cytokines and priming of activated microglia toward pro-inflammatory polarization, whereas TWS119 ameliorated microglia-mediated neuroinflammatory status following ischemic stroke and promoted angiogenesis by modulating microglia to anti-inflammatory phenotype. "
4.	Carcinogenesis 10/01/2023 - "Using a xenograft orthotopic model of breast tumorigenesis (4T1-Pcbp1-/-), we show here that PCBP1 knockdown-induced tumorigenesis is inhibited by activation of the WNT signaling via treating with the glycogen synthase kinase 3 beta inhibitor TWS119, but not the Akt2/Akt3 inhibitor GSK690693. "
5.	Stroke (Strokes) 12/06/2019 - "TWS119 was administrated from day 1 to 14 after stroke. " 12/06/2019 - "Wnt canonical pathway activator TWS119 drives microglial anti-inflammatory activation and facilitates neurological recovery following experimental stroke." 12/06/2019 - "TWS119 mitigated neurological deficits at days 14 and 21 after experimental stroke, paralleled by acceleration on angiogenesis and neural plasticity in the peri-infarct cortex. " 12/06/2019 - "Here, we explored whether Wnt/β-catenin pathway activator TWS119 facilitated long-term neurological recovery via modulating microglia polarization after experimental stroke. "

Related Drugs and Biologics

1.	Catenins
2.	Glycogen Synthase (Synthase I)
3.	pyrrolopyrimidine
4.	Cytokines
5.	Perforin
6.	Granzymes (Granzyme)
7.	Glycogen Synthase Kinase 3
8.	Glycogen Synthase Kinases
9.	Small Interfering RNA (siRNA)
10.	Messenger RNA (mRNA)