2-f)quinazoline-1,3-diamine N3- cyclopropyl- 7- ((4- (1- methylethyl)phenyl)methyl)- 7H- pyrrolo(3

a nonpeptide thrombin receptor antagonist; a PAR1 inhibitor; in SCH 203099 one methyl group is attached to the amine; structure in first source

Also Known As:

N3-cyclopropyl-7-((4-(1-methylethyl)phenyl)methyl)-7H-pyrrolo(3, 2-f)quinazoline-1,3-diamine; SCH 203099; SCH 79797; SCH-79797; SCH79797

Networked: 27 relevant articles (4 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - 2-f)quinazoline-1,3-diamine N3-cyclopropyl-7-((4-(1-methylethyl)phenyl)methyl)-7H-pyrrolo(3: 27
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinazolines: 402
      - 2-f)quinazoline-1,3-diamine N3-cyclopropyl-7-((4-(1-methylethyl)phenyl)methyl)-7H-pyrrolo(3: 27

Experts

1.	Gao, Feng: 2 articles (10/2019 - 03/2014)
2.	Strande, Jennifer L: 2 articles (09/2013 - 07/2007)
3.	Ma, Qingyi: 2 articles (05/2013 - 02/2013)
4.	Manaenko, Anatol: 2 articles (05/2013 - 02/2013)
5.	Yan, Junhao: 2 articles (05/2013 - 02/2013)
6.	Zhang, John H: 2 articles (05/2013 - 02/2013)
7.	Hu, Xiangyu: 1 article (01/2022)
8.	Pan, Yihuai: 1 article (01/2022)
9.	Qiu, Lili: 1 article (01/2022)
10.	Shen, Yan: 1 article (01/2022)

Related Diseases

1.	Brain Injuries (Brain Injury) 02/01/2013 - "PAR-1 antagonist SCH79797 ameliorates apoptosis following surgical brain injury through inhibition of ASK1-JNK in rats." 02/01/2013 - "The present study seeks to test 1) the effect of surgically induced brain injury (SBI) on thrombin activity, expression of thrombin's receptor PAR-1, and PAR-1 mediated apoptosis; 2) the effect of thrombin inhibition by argatroban and PAR-1 inhibition by SCH79797 on the development of secondary brain injury in the SBI model on rats. " 02/01/2017 - "These findings suggest that SCH79797 mitigates brain injury via anti-inflammatory and anti-apoptotic effects, possibly by modulating the extracellular signal-regulated kinase, c-Jun N-terminal kinase/c-Jun and phosphoinositide 3-kinase/Akt pathways."
2.	Lung Injury 01/01/2018 - "In this study, we administered SCH79797 via the intrapulmonary route 6 h after the establishment of Escherichia coli pneumonia and observed a significant improvement in survival, lung injury, bacterial clearance and inflammation. "
3.	Pneumonia (Pneumonitis) 01/01/2018 - "coli pneumonia that appear to be due, in part, to both neutrophil-stimulating and direct antibacterial effects of SCH79797." 01/01/2018 - "In this study, we administered SCH79797 via the intrapulmonary route 6 h after the establishment of Escherichia coli pneumonia and observed a significant improvement in survival, lung injury, bacterial clearance and inflammation. " 01/01/2018 - "As PAR1 is classically activated by the coagulation-based protease thrombin and leads to vascular leakage, our hypothesis was that PAR1 blockade with SCH79797 would be therapeutically beneficial in an experimental model of murine Gram-negative pneumonia. "
4.	Inflammation (Inflammations) 01/01/2018 - "In this study, we administered SCH79797 via the intrapulmonary route 6 h after the establishment of Escherichia coli pneumonia and observed a significant improvement in survival, lung injury, bacterial clearance and inflammation. "
5.	Lymphoma (Lymphomas) 05/01/2017 - "When the PAR1 inhibitor, SCH79797 (SCH), or a small interfering RNA (siRNA) targeting PAR1 were used to inhibit PAR1 signaling, a marked decrease in cell apoptosis, caspase‑3 activity and the expression of the pro‑apoptotic protein B‑cell lymphoma 2 (Bcl‑2) associated X (Bax), as well as increased expression of the anti‑apoptotic Bcl‑2 family member, myeloid cell leukemia 1 (Mcl‑1), were observed. "

Related Drugs and Biologics

1.	Thrombin
2.	Peptide Hydrolases (Proteases)
3.	Proteins (Proteins, Gene)
4.	Small Interfering RNA (siRNA)
5.	PAR-1 Receptor
6.	thrombin receptor peptide (42-47)
7.	Peptides (Polypeptides)
8.	argatroban (MPQA)
9.	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)
10.	Serine Proteases (Serine Protease)

Related Therapies and Procedures

1.	Punctures
2.	Ligation