Olivomycins

A mixture of several closely related glycosidic antibiotics obtained from Actinomyces (or Streptomyces) olivoreticuli. They are used as fluorescent dyes that bind to DNA and prevent both RNA and protein synthesis and are also used as antineoplastic agents.

Also Known As:

Networked: 57 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bukhman, Vladimir M: 2 articles (12/2011 - 01/2009)
2.	Dezhenkova, Lyubov G: 2 articles (12/2011 - 01/2009)
3.	Olsufyeva, Eugenia N: 2 articles (12/2011 - 01/2009)
4.	Preobrazhenskaya, Maria N: 2 articles (12/2011 - 01/2009)
5.	Shtil, Alexander A: 2 articles (12/2011 - 01/2009)
6.	Tevyashova, Anna N: 2 articles (12/2011 - 01/2009)
7.	Durandin, Nikita A: 1 article (12/2011)
8.	Isakova, Elena B: 1 article (12/2011)
9.	Kuzmin, Vladimir A: 1 article (12/2011)
10.	Luzikov, Yury N: 1 article (12/2011)

Related Diseases

1.	Neoplasms (Cancer) 02/01/1971 - "[Cytological study of the combined effect of olivomycin and gamma-irradiation on HeLa tumor cell culture]." 06/01/1964 - "[EXPERIMENTAL STUDIES ON THE ANTI-TUMOR ACTIVITY OF VARIOUS OLIVOMYCIN COMPONENTS]." 04/01/2005 - "Olivomycin induces tumor cell apoptosis and suppresses p53-induced transcription." 05/01/1981 - "[Mechanism of various degrees of tumor sensitivity to olivomycin]." 06/01/1978 - "Prolonged exposure to olivomycin resulted in decreased transplantability of the tumor cells. "
2.	Carcinoma (Carcinomatosis) 05/01/1981 - "Study on the kinetics of rRNA synthesis after addition of olivomycin showed that the maximum inhibition of rRNA synthesis in the cells of Ehrlich's carcinoma was achieved 1 hour after the drug addition. " 03/01/1975 - "[Olivomycin-C14 distribution in the body of mice with Ehrlich's carcinoma resistant to the preparation]." 12/01/1977 - "[Therapy of ovarian carcinoma with olivomycin]." 05/01/1981 - "The efficiency of the rRNA synthesis inhibition by olivomycin on its addition to the cells of Ehrlich's carcinoma and Zajdela's hepatoma in vitro was of the same order. " 05/01/1966 - "Action of olivomycin on cells of Erlich's ascites carcinoma."
3.	Sarcoma (Soft Tissue Sarcoma) 07/01/1963 - "[EXPERIMENTAL STUDIES ON THE ANTINEOPLASTIC EFFECT OF OLIVOMYCIN IN ASSOCIATION WITH SOME SYNTHETIC CYTOSTATIC DRUGS IN CROCKER'S SARCOMA]."
4.	Non-Hodgkin Lymphoma (Lymphosarcoma) 05/01/1972 - "[Distribution of C 14 -olivomycin in subcellular fractions of various organs of mice with transplantable lymphosarcoma]." 03/01/1971 - "[Seasonal changes in the rate of development and sensitivity of lymphosarcoma to olivomycin in male and female albino mice]." 04/01/1972 - "[Combined use of rubomycin and olivomycin in treatment of murine lymphosarcoma]." 07/01/1978 - "Diacarb or lasix in combination with olivomycin increased the antibiotic antiblastomic activity and toxicity when used for the course treatment of mice with transplanted lymphosarcoma LIO-I. The chemotherapeutic indices of such combinations did not differ from those of olivomycin used alone. " 04/01/1975 - "Combined use of rubomycin and olivomycin with diacarb in treatment of rats with Pliss lymphosarcoma increased the antiblastomic activity of the antibiotics. "
5.	Leukemia 06/01/1978 - "A total of 52-fold passages of leukemia L-1210 were carried out for a year on mice treated intraperitoneally with olivomycin. " 01/01/2009 - "One of the novel derivatives showed a marked inhibitory activity against Topo-I, a pronounced antitumor activity in in vivo experiments on mice bearing leukemia P-388 and lower toxic side effects compared with the parent olivomycin I." 05/01/1964 - "TREATMENT OF LEUKEMIA BY ANTITUMOR ANTIBIOTICS OLIVOMYCIN (16749) AND 6613." 08/01/1963 - "[USE OF THE ANTINEOPLASTIC ANTIBIOTICS OLIVOMYCIN (16749) AND 6613 IN THE TREATMENT OF LEUKEMIAS]." 08/01/1969 - "Effect of olivomycins, chromomycins and mithramycin on leukemia La of mice of strain C57B1]."

Related Drugs and Biologics

1.	Anti-Bacterial Agents (Antibiotics)
2.	Antineoplastic Agents (Antineoplastics)
3.	Cytostatic Agents
4.	Daunorubicin (Cerubidine)
5.	Streptonigrin (Nigrin)
6.	RNA (Ribonucleic Acid)
7.	Plicamycin
8.	Doxorubicin (Adriamycin)
9.	DNA (Deoxyribonucleic Acid)
10.	Dactinomycin (Actinomycin)

Related Therapies and Procedures

1.	Therapeutics
2.	Combination Drug Therapy (Combination Chemotherapy)
3.	Drug Therapy (Chemotherapy)