HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Dactinomycin (Actinomycin)

A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
Also Known As:
Actinomycin; Actinomycin D; Cosmegen; Cosmegen Lyovac; Lyovac-Cosmegen; Lyovac Cosmegen; Lyovac, Cosmegen; LyovacCosmegen; Meractinomycin
Networked: 2073 relevant articles (105 outcomes, 228 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1. Xiang, Yang: 10 articles (01/2022 - 06/2004)
2. Green, Daniel M: 9 articles (11/2021 - 06/2003)
3. Anderson, James R: 9 articles (01/2018 - 11/2009)
4. Thompson, John F: 8 articles (04/2022 - 01/2006)
5. Hawkins, Douglas S: 8 articles (01/2022 - 11/2009)
6. Shamberger, Robert C: 8 articles (01/2018 - 06/2003)
7. Ren, Tong: 7 articles (01/2022 - 01/2014)
8. Wan, Xirun: 7 articles (01/2022 - 06/2004)
9. Grundy, Paul E: 7 articles (01/2019 - 05/2007)
10. Breslow, Norman E: 7 articles (01/2014 - 09/2004)

Related Diseases

1. Neoplasms (Cancer)
2. Gestational Trophoblastic Disease (Trophoblastic Neoplasms, Gestational)
3. Wilms Tumor (Wilm's Tumor)
4. Rhabdomyosarcoma
5. Ewing Sarcoma (Sarcoma, Ewing)

Related Drugs and Biologics

1. Vincristine (Oncovin)
2. Methotrexate (Mexate)
3. Cyclophosphamide (Cytoxan)
4. Etoposide (VP 16)
5. Doxorubicin (Adriamycin)
6. Cisplatin (Platino)
7. Ifosfamide
8. Bleomycin (Blenoxane)
9. Fluorouracil (Carac)
10. Vinblastine (Vinblastine Sulfate)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Combination Drug Therapy (Combination Chemotherapy)
3. Therapeutics
4. Radiotherapy
5. Adjuvant Chemotherapy