[Olivomycin-C14 distribution in the body of mice with Ehrlich's carcinoma resistant to the preparation].

Abstract

Tests on mice with Ehrlich's carcinoma (solid and ascitic forms) evidenced that following a single intravenous injection of glycomycin-C14 its maximal concentrations are definable in 30 minutes--1 hour in the kidneys, liver, spleen and the blood (plasma). Six to seven percent of the total radioactivity of the tumor cells fell to the share of the nuclear fraction, while the rest of 93-94 per cent was made up by the remaining cellular components.

• Authors: A E Vatin
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1975 Mar-Apr Vol. 38 Issue 2 Pg. 224-6 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Raspredelenie olivomitsina-C14 v organizme mysheĭ s kartsinomoĭ Erlikha, ustoĭchivoĭ k preparatu
• PMID: 1227896 (Publication Type: English Abstract, Journal Article)

Chemical References

• Carbon Radioisotopes
• Olivomycins

Topics

• Animals
• Blood (metabolism)
• Carbon Radioisotopes
• Carcinoma, Ehrlich Tumor (metabolism)
• Drug Resistance
• Kidney (metabolism)
• Liver (metabolism)
• Male
• Mice
• Neoplasm Transplantation
• Olivomycins (metabolism)
• Spleen (metabolism)
• Time Factors