[Effect of diuretics (diacarb and lasix) on the experimental antitumor activity, toxicity and pharmacokinetics of the antibiotic, olivomycin].

Abstract

Diacarb or lasix in combination with olivomycin increased the antibiotic antiblastomic activity and toxicity when used for the course treatment of mice with transplanted lymphosarcoma LIO-I. The chemotherapeutic indices of such combinations did not differ from those of olivomycin used alone. Diacarb decreased excretion of olivomycin with the urine in healthy mice, while lasix increased it.

• Authors: E S Stepanova, V A Liashenko
• Journal: Antibiotiki (Antibiotiki) Vol. 23 Issue 7 Pg. 617-21 (Jul 1978) ISSN: 0003-5637 [Print] Russia (Federation)
• Vernacular Title: Vliianie diuretikov (diakarba i laziksa) na protivoopukholevuiu aktivnost', toksichnost' i farmakokinetiku antibiotika olivomitsina v éksperimente.
• PMID: 581050 (Publication Type: English Abstract, Journal Article)

Chemical References

• Drug Combinations
• Olivomycins
• Furosemide
• Acetazolamide

Topics

• Acetazolamide (therapeutic use)
• Animals
• Diuresis (drug effects)
• Drug Combinations
• Drug Evaluation, Preclinical
• Drug Interactions
• Female
• Furosemide (therapeutic use)
• Kinetics
• Lymphoma, Non-Hodgkin (drug therapy)
• Male
• Mice
• Neoplasms, Experimental (drug therapy)
• Olivomycins (pharmacology, therapeutic use, toxicity)
• Rats