Narcolepsy

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1015 relevant articles (69 outcomes, 162 trials/studies) found for this Disease

Description: A condition characterized by recurrent episodes of daytime somnolence and lapses in consciousness (microsomnias) that may be associated with automatic behaviors and AMNESIA. CATAPLEXY; SLEEP PARALYSIS, and hypnagogic HALLUCINATIONS frequently accompany narcolepsy. The pathophysiology of this disorder includes sleep-onset rapid eye movement (REM) sleep, which normally follows stage III or IV sleep. (From Neurology 1998 Feb;50(2 Suppl 1):S2-S7)

Also Known As:

Gelineau's Syndrome; Narcoleptic Syndrome; Gelineau's Syndromes; Gelineaus Syndrome; Narcolepsy Cataplexy Syndrome; Narcolepsy-Cataplexy Syndromes; Narcoleptic Syndromes; Sleep, Paroxysmal; Syndrome, Gelineau; Syndrome, Gelineau's; Syndrome, Narcolepsy-Cataplexy; Syndrome, Narcoleptic; Syndromes, Gelineau's; Syndromes, Narcolepsy-Cataplexy; Syndromes, Narcoleptic; Gelineau Syndrome; Narcolepsy-Cataplexy Syndrome; Paroxysmal Sleep

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 3643

Sleep Disorders: 691

Dyssomnias: 9

Intrinsic Sleep Disorders: 6

Disorders of Excessive Somnolence: 255

Narcolepsy: 1015

Cataplexy: 360

Mental Disorders: 1850

Sleep Disorders: 691

Dyssomnias: 9

Intrinsic Sleep Disorders: 6

Disorders of Excessive Somnolence: 255

Narcolepsy: 1015

Cataplexy: 360

Related Diseases

1.	Cataplexy
2.	Disorders of Excessive Somnolence (Hypersomnia)
3.	Idiopathic Hypersomnolence
4.	Circadian Rhythm Sleep Disorders (Delayed Sleep Phase Syndrome)
5.	Fatigue

Experts

1.	Mignot, E: 16 articles (10/2005 - 01/2000)
2.	Mignot, Emmanuel: 15 articles (08/2008 - 01/2002)
3.	Nishino, S: 14 articles (12/2004 - 01/2000)
4.	Nishino, Seiji: 10 articles (08/2008 - 03/2002)
5.	Lammers, Gert Jan: 7 articles (06/2008 - 10/2002)
6.	Kanbayashi, Takashi: 7 articles (12/2006 - 03/2002)
7.	Ripley, B: 7 articles (12/2001 - 01/2000)
8.	Overeem, Sebastiaan: 6 articles (06/2008 - 10/2002)
9.	Lin, Ling: 6 articles (01/2008 - 06/2002)
10.	Dauvilliers, Yves: 5 articles (04/2008 - 12/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Narcolepsy:

1.	modafinil (armodafinil)FDA Link 01/01/2005 - "The clinical efficacy of modafinil, combined with improved safety over CNS stimulants, has made it the most prescribed medication for the treatment of ES associated with narcolepsy. " 09/01/2009 - "Compared with placebo, mean sleep latency (coprimary endpoint) was significantly improved with armodafinil 150 or 250 mg once daily in patients with OSA or narcolepsy, and with armodafinil 150 mg once daily in patients with SWSD, as assessed by the Multiple Sleep Latency Test (MSLT) or the Maintenance of Wakefulness Test (MWT). " 01/15/2007 - "In conclusion, modafinil did not influence thymopsychic variables in narcolepsy, but it significantly improved cognitive performance, which may be related to medial prefrontal activity processes identified by LORETA." 04/01/2006 - "CONCLUSIONS: Armodafinil significantly improved ability to sustain wakefulness throughout the day in patients with narcolepsy. " 06/01/1998 - "Modafinil is an alerting substance which has been used successfully to treat narcolepsy. " Order ALL the reference details at left...
2.	Sodium Oxybate (gamma Hydroxybutyrate)FDA Link 09/01/2009 - "The nightly administration of sodium oxybate results in significant reduction in the nocturnal sleep disruption of patients with narcolepsy." 02/01/2002 - "CONCLUSIONS: Sodium oxybate significantly improved symptoms in patients with narcolepsy and was well tolerated." 10/15/2005 - "CONCLUSIONS: When combined with its previously demonstrated anticataplectic effects, the results of the current study indicate sodium oxybate is the first drug to demonstrate efficacy for the 2 major symptoms of narcolepsy." 10/15/2005 - "A double-blind, placebo-controlled study demonstrates sodium oxybate is effective for the treatment of excessive daytime sleepiness in narcolepsy." 03/01/2008 - "Sodium oxybate appears to be an effective and well-tolerated treatment for all the key symptoms of the two forms of narcolepsy." Order ALL the reference details at left...
3.	orexins (orexin)IBA 11/01/2003 - "It is very useful to measure CSF orexin for the diagnosis of early onset narcolepsy." 08/01/2009 - "Experimental models have been generated in order to study the physiology of the orexin system and narcolepsy. " 08/01/2009 - "In narcoleptic patients, structural and functional brain imaging studies have suggested the involvement of the hypothalamus in the pathophysiology of narcolepsy, plausibly consistent with an impairment of the hypocretin-orexin system. " 01/01/2009 - "Further studies are required to address the hypothesis that excessive IGFBP3 expression may initiate hypocretin cell death and cause narcolepsy." 08/01/2008 - "STUDY OBJECTIVE: To determine whether hypocretin receptor gene (hcrtR1 and hcrtR2) expression is affected after long-term hypocretin ligand loss in humans and animal models of narcolepsy. " Order ALL the reference details at left...
4.	AmphetaminesIBA 04/01/1993 - "Amphetamines and narcolepsy: use of the Stanford database." 02/28/1991 - "Narcolepsy--attitudes and amphetamines." 11/01/1975 - "Amphetamines had been given to 71 patients for periods of up to 33 years with adequate, but rarely complete, control of narcolepsy. " 02/01/2009 - "Although they have long been used effectively to treat attention deficit hyperactivity disorder (ADHD) in children and adolescents, amphetamines are now being prescribed increasingly as maintenance therapy for ADHD and narcolepsy in adults, considerably extending the period of potential exposure. " 02/01/1999 - "There is no cure for narcolepsy; however, symptomatic relief may be achieved through a trial-and-error combination of amphetamines and tricyclic antidepressants. " Order ALL the reference details at left...
5.	Intravenous Immunoglobulins (IVIG)FDA Link 12/01/2003 - "Clinical efficacy of high-dose intravenous immunoglobulins near the onset of narcolepsy in a 10-year-old boy." 09/01/2006 - "In another uncontrolled study, IVIg reduced the number of cataplectic attacks in narcolepsy patients. " 07/01/2006 - "Follow-up of four narcolepsy patients treated with intravenous immunoglobulins." 01/01/2006 - "Recent pilot open trials with intravenous immunoglobulins appear an effective treatment of cataplexy if applied at early stages of narcolepsy. " 10/01/2008 - "Our data partially support the recent report of the efficacy of IVIg treatment in early diagnosed narcolepsy with cataplexy and support the need for a controlled multicenter clinical trial on IVIg in narcolepsy." Order ALL the reference details at left...
6.	GABA-B Receptors (Receptor, GABA-B)IBA 06/01/2007 - "Differential involvement of GABA(B) receptor subtypes, or differential interactions with GABA(B) receptors, may possibly explain why GHB is effective for treating narcolepsy and is abused whereas baclofen is not." 08/01/2008 - "Differential interactions of glutamate with the GABA(B) receptor mechanisms mediating the effects of GHB and baclofen may explain why GHB is effective for treating narcolepsy and is abused, whereas baclofen is not." 06/01/2005 - "gamma-Hydroxybutyrate (GHB), a therapeutic for narcolepsy and a drug of abuse, has several mechanisms of action that involve GHB and GABA(B) receptors, metabolism to GABA, and modulation of dopaminergic signaling. " 01/01/2002 - "Since the sensitivity of GABA(C) receptors for GABA is higher than that of GABA(A) and GABA(B) receptors, GABA(C) receptor agonists and antagonists, when available for clinical practice, could open up a new era for therapy of troubles such as insomnia, epilepsy and narcolepsy. " 07/01/2009 - "This study was performed to evaluate the actions of baclofen and sodium oxybate, two medications with gamma-aminobutyric acid type B (GABA(B)) receptor agonist properties, on symptoms of narcolepsy in drug-naïve teenagers. " Order ALL the reference details at left...
7.	Antidepressive Agents (Antidepressants)IBA 01/01/2008 - "AUTHORS' CONCLUSIONS: There was no good quality evidence that antidepressants are effective for narcolepsy or improve quality of life. " 01/01/2005 - "AUTHORS' CONCLUSIONS: There was no good quality evidence that antidepressants are effective for narcolepsy or improve quality of life. " 01/01/2008 - "There is a clear need for well-designed randomised controlled trials to assess the effect of antidepressants on narcolepsy." 01/01/2005 - "There is a clear need for well-designed randomised controlled trials to assess the effect of antidepressants on narcolepsy." 01/01/2008 - "Antidepressant drugs for narcolepsy." Order ALL the reference details at left...
8.	Tricyclic Antidepressive Agents (Tricyclic Antidepressants)IBA 02/01/1997 - "Medications for the treatment of narcolepsy consist of central nervous system (CNS) stimulants to control the somnolent symptoms and tricyclic antidepressants to control the rapid-eye-movement (REM) sleep related symptoms. " 09/19/1992 - "Besides stimulants against daytime somnolence and tricyclic antidepressants to suppress cataplectic attacks, some new drugs have been administered successfully against the various symptoms of narcolepsy in recent years." 09/01/1998 - "The cataplexy associated with narcolepsy can be managed with tricyclic antidepressants. " 02/01/1999 - "There is no cure for narcolepsy; however, symptomatic relief may be achieved through a trial-and-error combination of amphetamines and tricyclic antidepressants. " 06/01/2005 - "In the past, narcolepsy was primarily treated using amphetamine-like stimulants and tricyclic antidepressants. " Order ALL the reference details at left...
9.	Methylphenidate (Ritalin)FDA LinkGeneric 06/01/2009 - "When methylphenidate was used for disorders other than narcolepsy, such as depression, dependence on the drug and abuse became an issue, and methylphenidate is no longer available for depression. " 02/01/2001 - " (3) According to the results of our literature search, which includes a clinical expert report from Novartis Pharma, the file on methylphenidate in narcolepsy is mainly based on "clinical experience": only three case series, totalling fewer than 200 patients, have been published. " 02/01/2001 - " (2) After many years of off-license use in the treatment of narcolepsy, methylphenidate is now licensed for this indication in France. " 02/01/2001 - "Methylphenidate and narcolepsy: new indication. " 03/01/2000 - "Methylphenidate hydrochloride ('Ritalin') was the prescribers' most popular agent and 'narcolepsy' was the most frequently cited clinical indication for psychostimulants. " Order ALL the reference details at left...
10.	Baclofen FDA LinkGeneric 06/01/2007 - "Differential involvement of GABA(B) receptor subtypes, or differential interactions with GABA(B) receptors, may possibly explain why GHB is effective for treating narcolepsy and is abused whereas baclofen is not." 08/01/2008 - "Differential interactions of glutamate with the GABA(B) receptor mechanisms mediating the effects of GHB and baclofen may explain why GHB is effective for treating narcolepsy and is abused, whereas baclofen is not." 07/01/2009 - "Twenty-six narcoleptic teenagers with recent onset of narcolepsy-cataplexy syndrome who were human leukocyte antigen DQB1 0602 positive were matched for age and sex and received either baclofen or sodium oxybate. " 07/01/2009 - "Narcolepsy: action of two gamma-aminobutyric acid type B agonists, baclofen and sodium oxybate." 07/01/2009 - "This study was performed to evaluate the actions of baclofen and sodium oxybate, two medications with gamma-aminobutyric acid type B (GABA(B)) receptor agonist properties, on symptoms of narcolepsy in drug-naïve teenagers. " Order ALL the reference details at left...

Therapies and Procedures

1.	Transplantation (Transplant Recipients) 06/01/2005 - "In the future, for atypical cases(poorly responsive to therapy), genetic, CSF, and brain imaging studies, and possibly even neuronal transplantation may prove beneficial in the assessment and treatment of idiopathic narcolepsy." Order ALL the reference details at left...
2.	Immunotherapy 06/01/2008 - "Careful titration up to an adequate level is essential both to obtain positive results and avoid adverse effects; 3) A series of new treatments are currently being tested, either in animal models or in humans, They include novel stimulant and anticataplectic drugs, endocrine therapy, and, more attractively, totally new approaches based on the present state of knowledge of the pathophysiology of narcolepsy with cataplexy, hypocretine-based therapies, and immunotherapy." Order ALL the reference details at left...
3.	Renal Dialysis (Hemodialysis) 05/01/1996 - "Effective treatment of narcolepsy with codeine in a patient receiving hemodialysis." Order ALL the reference details at left...
4.	Drug Therapy (Chemotherapy) 02/01/1997 - "While this study did not examine symptom ratings on and off drug therapy, these findings do suggest that narcoleptics may have to utilize behavioral strategies with their medication regimens to effectively cope with narcolepsy's adverse effects on daily life." 04/01/2007 - "BACKGROUND AND PURPOSE: No previous research has examined the psychosocial adjustment of chronic narcolepsy patients following efficacious pharmacotherapy. " 03/30/2004 - "Currently available treatments for narcolepsy are only palliative, symptom-oriented pharmacotherapies. " 01/01/2002 - "The favourable benefit-risk ratio of pharmacotherapy is greater if one considers the reduced risk to society of vehicle crashes and workplace mishaps that might be precipitated by attentional lapses or sleep attacks in the untreated or under-treated patient with narcolepsy." 01/01/2002 - "Benefits and risks of pharmacotherapy for narcolepsy." Order ALL the reference details at left...
5.	Transplants (Transplant) 08/14/2006 - "This study highlights the potential use of transplants as a therapeutical tool in order to treat narcolepsy." 08/01/2009 - "This article reviews the current understanding of narcolepsy and discusses the opportunity to explore the potential use of transplants as a therapeutical tool in order to treat narcolepsy." 09/01/2007 - "In the present review we describe an overview on narcolepsy, the hypocretinergic system, experimental models in narcolepsy and the use of transplants as an alternative therapeutic tool." Order ALL the reference details at left...

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