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Sodium Oxybate (gamma Hydroxybutyrate)

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The sodium salt of 4-hydroxybutyric acid. Anesthetic used for both induction and maintenance. It may cause bradycardia and dyskinesias.

Also Known As:

gamma Hydroxybutyrate; Xyrem; Gamma-OH; Köhler Brand of Sodium Oxybate; Orphan Brand of Sodium Oxybate; SERB Brand of Sodium Oxybate; Somsanit; 4 Hydroxybutyrate Sodium; Gamma OH; Oxybate, Sodium; Oxybutyrate, Sodium; Sodium gamma Hydroxybutyrate; 4-Hydroxybutyrate Sodium; Oxybate Sodium; Sodium Oxybutyrate; Sodium gamma-Hydroxybutyrate; gamma-Hydroxybutyrate; Butanoic acid, 4-hydroxy-, monosodium salt

Networked: 351 relevant articles (43 outcomes, 47 trials/studies) for this Drug, Comments

Relationship Network

Drug Context: Research Results

Organic Chemicals: 45
- Carboxylic Acids: 64
  - Hydroxy Acids: 19
    - 3-Hydroxybutyric Acid: 541
      - Hydroxybutyrates: 1
        Sodium Oxybate: 351
        tuliposide A: 2
        6-tuliposide A: 1
        tuliposide D: 1
  - Acyclic Acids
    - Butyric Acids: 6
      - 3-Hydroxybutyric Acid: 541
        Hydroxybutyrates: 1
        Sodium Oxybate: 351
        tuliposide A: 2
        6-tuliposide A: 1
        tuliposide D: 1

Experts

1.	Black, Jed: 6 articles (01/2010 - 11/2004)
2.	Hornfeldt, Carl S: 6 articles (09/2009 - 06/2002)
3.	Nishino, Seiji: 5 articles (03/2010 - 06/2005)
4.	Mignot, Emmanuel: 5 articles (01/2010 - 11/2004)
5.	Dauvilliers, Yves: 5 articles (01/2010 - 12/2004)
6.	Carter, Lawrence P: 5 articles (12/2009 - 01/2004)
7.	Zvosec, Deborah L: 5 articles (09/2009 - 01/2004)
8.	Smith, Stephen W: 5 articles (09/2009 - 01/2004)
9.	Dyer, Jo Ellen: 5 articles (01/2009 - 07/2003)
10.	Rabasseda, X: 5 articles (06/2006 - 06/2004)

Related Diseases

1.	Narcolepsy 09/01/2009 - "The nightly administration of sodium oxybate results in significant reduction in the nocturnal sleep disruption of patients with narcolepsy." 02/01/2002 - "CONCLUSIONS: Sodium oxybate significantly improved symptoms in patients with narcolepsy and was well tolerated." 10/15/2005 - "CONCLUSIONS: When combined with its previously demonstrated anticataplectic effects, the results of the current study indicate sodium oxybate is the first drug to demonstrate efficacy for the 2 major symptoms of narcolepsy." 10/15/2005 - "A double-blind, placebo-controlled study demonstrates sodium oxybate is effective for the treatment of excessive daytime sleepiness in narcolepsy." 03/01/2008 - "Sodium oxybate appears to be an effective and well-tolerated treatment for all the key symptoms of the two forms of narcolepsy." Order ALL the reference details at left...
2.	Cataplexy 09/01/2005 - "CONCLUSIONS: In the largest study of its kind, sodium oxybate was highly effective for the treatment of cataplexy. " 03/01/2006 - "CONCLUSIONS: Sodium oxybate is safe and effective for the treatment of cataplexy. " 03/01/2006 - "In placebo-controlled trials, sodium oxybate demonstrated efficacy in reducing the number of cataplexy attacks. " 03/01/2006 - "Study selection included human trials evaluating safety and efficacy of sodium oxybate for the treatment of cataplexy. " 03/01/2004 - "CONCLUSIONS: This controlled trial provides evidence supporting the long-term efficacy of sodium oxybate for the treatment of cataplexy. " Order ALL the reference details at left...
3.	Reperfusion Injury 05/01/1994 - "Treatment with gamma-hydroxybutyrate (GHB), a compound that we have previously demonstrated to be highly effective in preventing ischemia-reperfusion injury, significantly reduced both the microvascular stasis and leukocyte accumulation in all three vascular beds. " 05/01/2004 - "gamma-hydroxybutyrate (GHB) has been reported to exert protective effects against ischemia-reperfusion injury to various organs. " 10/01/1992 - "We have previously shown that gamma-hydroxybutyrate (GHB) protects the small intestine against ischemia/reperfusion injury. " 05/01/2004 - "gamma-hydroxybutyrate protects the liver from warm ischemia-reperfusion injury in rat." 01/01/1997 - "Gamma-hydroxybutyrate (GHB), an endogenous regulator of energy metabolism, showed beneficial effects on experimental intestinal ischemia/reperfusion injury and liver graft function. " Order ALL the reference details at left...
4.	Brain Ischemia (Cerebral Ischemia) 05/26/2000 - "In conclusion, these results indicate that gamma-hydroxybutyrate provides significant protection against both histological and behavioral consequences of transient global cerebral ischemia in rats." 01/01/2008 - "Gamma-hydroxybutyrate accelerates functional recovery after focal cerebral ischemia." 02/06/2004 - "Effect of late treatment with gamma-hydroxybutyrate on the histological and behavioral consequences of transient brain ischemia in the rat." 05/26/2000 - "Neuroprotective effect of gamma-hydroxybutyrate in transient global cerebral ischemia in the rat." 09/01/1992 - "[Effects of gamma-hydroxybutyrate on monoamine metabolism and protein synthesis after transient global cerebral ischemia]" Order ALL the reference details at left...
5.	Myoclonus (Nocturnal Myoclonus) 03/01/2009 - "We report a 16-year-old patient with severe treatment-refractory posthypoxic myoclonus, which improved markedly with administration of the drug sodium oxybate." 03/01/2009 - "A patient with intractable posthypoxic myoclonus (Lance-Adams syndrome) treated with sodium oxybate." 12/27/2005 - "A single-blind, open-label trial of sodium oxybate for myoclonus and essential tremor." 10/01/2005 - "In a prior article published in this journal, we reported a patient with severe posthypoxic myoclonus whose myoclonus improved with ethanol and also with treatment with sodium oxybate. " 06/01/2005 - "We conducted an open-label, dose-finding, blinded-rating trial of gamma-hydroxybutyric acid (Xyrem) in a single patient with severe alcohol-responsive posthypoxic myoclonus refractory to treatment with standard antimyoclonic agents. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	modafinil (armodafinil)
2.	Sodium Oxybate (gamma Hydroxybutyrate)
3.	Tricyclic Antidepressive Agents (Tricyclic Antidepressants)
4.	gamma-Aminobutyric Acid (GABA)
5.	Hypnotics and Sedatives (Sedatives)
6.	Antidepressive Agents (Antidepressants)
7.	Ethanol (Ethyl Alcohol)
8.	GABA-B Receptors (Receptor, GABA-B)
9.	Fluoxetine (Prozac)
10.	Amphetamines

Related Therapies and Procedures

1.	Anesthesia
2.	Intravenous Injections
3.	Stents
4.	Drug-Eluting Stents
5.	Warm Ischemia

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