|1.||Zoulim, Fabien: 6 articles (08/2013 - 02/2002)|
|2.||Dandri, Maura: 5 articles (07/2010 - 09/2006)|
|3.||Petersen, Joerg: 4 articles (07/2010 - 09/2006)|
|4.||Lutgehetmann, Marc: 4 articles (07/2010 - 09/2006)|
|5.||Freitas, Natalia: 3 articles (09/2015 - 01/2015)|
|6.||Gudima, Severin O: 3 articles (09/2015 - 01/2015)|
|7.||Menne, Stephan: 3 articles (09/2015 - 01/2015)|
|8.||Mason, William S: 3 articles (05/2015 - 09/2004)|
|9.||Zhang, Yong-Yuan: 3 articles (01/2015 - 10/2003)|
|10.||Volz, Tassilo: 3 articles (07/2010 - 09/2006)|
05/18/2015 - "However, CHB infection cannot be completely eradicated, due to the persistence of covalently closed circular DNA in the nucleus of infected hepatocytes, which may explain HBV reactivation. "
02/17/2004 - "The mechanisms that control the nuclear pool of viral covalently closed circular DNA (cccDNA) transcriptional template of HBV, which must be eliminated to eradicate infection, have been difficult to resolve. "
09/01/1994 - "In another three woodchucks, though productive infection was just as rapidly cleared, viral covalently closed circular DNA remained for weeks to months after other indicators of virus infection had disappeared from the liver. "
09/01/2008 - "Rolling circle amplification, a powerful tool for genetic and functional studies of complete hepatitis B virus genomes from low-level infections and for directly probing covalently closed circular DNA."
12/02/2015 - "Fruit trees of different Brazilian regions displaying virus-like symptoms were evaluated for infection by circular DNA viruses. "
|2.||Chronic Hepatitis B
01/01/2014 - "Persistence of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) under current antiviral therapy is a major barrier to eradication of chronic hepatitis B (CHB). "
01/01/2012 - "Validation of a sensitive and specific real-time PCR for detection and quantitation of hepatitis B virus covalently closed circular DNA in plasma of chronic hepatitis B patients."
07/01/2009 - "Evidence that methylation of hepatitis B virus covalently closed circular DNA in liver tissues of patients with chronic hepatitis B modulates HBV replication."
06/01/2009 - "Validation of a sensitive and specific real-time PCR for detection and quantitation of hepatitis B virus covalently closed circular DNA in plasma of chronic hepatitis B patients."
06/01/2008 - "To quantitatively detect hepatitis B virus covalently closed circular DNA (HBV cccDNA) in sera of chronic hepatitis B patients with a newly established assay. "
10/01/2008 - "Hepatitis B virus covalently closed circular DNA in the serum of patients with hepatitis B, peripheral mononuclear cells (PBMC) and liver tissue distribution. "
01/01/2008 - "The final goal in hepatitis B therapy is eradication of the hepatitis B virus (HBV) replication template, the so-called covalently closed circular DNA (cccDNA). "
11/01/1984 - "Hepatitis B virions in plasma (Dane particles) are known to contain small circular DNA molecules. "
01/01/2014 - "[Quantitative determination of HBsAg in blood sera and hepatitis B virus covalently closed circular DNA in liver tissue as markers of chronic viral hepatitis B activity]."
01/01/2013 - "Uracil DNA glycosylase counteracts APOBEC3G-induced hypermutation of hepatitis B viral genomes: excision repair of covalently closed circular DNA."
|4.||Hepatocellular Carcinoma (Hepatoma)
10/01/2006 - "Quantification of hepatitis B virus covalently closed circular DNA in patients with hepatocellular carcinoma."
06/01/2001 - "Detection of covalently closed circular DNA in hepatoma cell lines and in primary hepatocytes indicated that an intracellular replication cycle independent from the transferred linear viral genome was established. "
02/01/2001 - "Hepatitis B virus (HBV) virion and covalently closed circular DNA formation in primary tupaia hepatocytes and human hepatoma cell lines upon HBV genome transduction with replication-defective adenovirus vectors."
05/01/2010 - "Treatment of DHBV particles with endosome prepared from duck liver led to cleavage of the large envelope protein, and such viral preparation could generate a small amount of covalently closed circular DNA in LMH cells, a chicken hepatoma cell line resistant to DHBV infection. "
01/01/2009 - "In this study, we found that IL-6 was able to effectively suppress hepatitis B virus (HBV) replication and prevent the accumulation of HBV covalently closed circular DNA (cccDNA) in a human hepatoma cell line. "
09/01/1998 - "The aim of this study was to investigate the effect of fractionated radiation treatment, given in daily doses similar to those administered clinically, on the stability of extrachromosomal circular DNA molecules in cancer cells. "
08/01/2009 - "Small polydispersed circular DNA contains strains of mobile genetic elements and occurs more frequently in permanent cell lines of malignant tumors than in normal lymphocytes."
05/03/2000 - "These analysis showed that the fused TR region contains a large but variable number of TR units (ranging from 16 to 75) and that the viral genome is present as extrachromosomal circular DNA in these tumors in vivo, with occasional ladders of heterogeneous linear termini reflecting lytic replication. "
05/01/1999 - "Extrachromosomal circular DNA molecules are prevalent in cancer cells and harbor amplified genes, such as oncogenes and drug resistance genes, that can provide a selective growth advantage to cancer cells. "
01/01/1992 - "The procedure should be useful as a routine screen of primary tumor cells for the presence of extrachromosomal circular DNA and should permit the preparation of specific probes ot aid in their detailed characterizations."
|1.||DNA (Deoxyribonucleic Acid)
|2.||Antiviral Agents (Antivirals)
|3.||Hepatitis B Surface Antigens (HBsAg)
|5.||Hepatitis B e Antigens
|7.||Interleukin-6 (Interleukin 6)
|8.||Viral Envelope Proteins
|9.||RNA (Ribonucleic Acid)
|1.||Highly Active Antiretroviral Therapy (HAART)
|3.||Transplantation (Transplant Recipients)