Superhelical DNA (Supercoiled DNA)

Circular duplex DNA isolated from viruses, bacteria and mitochondria in supercoiled or supertwisted form. This superhelical DNA is endowed with free energy. During transcription, the magnitude of RNA initiation is proportional to the DNA superhelicity.

Also Known As:

Networked: 59 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Feng, Fude: 2 articles (05/2019 - 07/2018)
2.	Ji, Jinkai: 2 articles (05/2019 - 07/2018)
3.	Wu, Tiantian: 2 articles (05/2019 - 07/2018)
4.	Zhang, Yajie: 2 articles (05/2019 - 07/2018)
5.	Huang, Yun: 1 article (07/2018)
6.	Li, Zhiliang: 1 article (07/2018)
7.	Schanze, Kirk S: 1 article (07/2018)
8.	Yuan, Hao: 1 article (07/2018)
9.	Ashley, Rachel E: 1 article (10/2017)
10.	Berger, James M: 1 article (10/2017)

Related Diseases

1.	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 01/01/1998 - "In the present study, we present evidence suggesting that the molecular basis for the anti-proliferative activity of these drugs is the inhibition of topoisomerase II. The NBQ-2 derivatives inhibited the relaxation of supercoiled DNA plasmid pRYG mediated by purified human topoisomerase II. Inhibition of the decatenation of kinetoplast DNA mediated by partially purified topoisomerase II extracted from the human histiocytic lymphoma U937 (a cell line previously shown to be sensitive to the drugs) was also caused by these drugs. "
2.	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 06/01/2006 - "The preliminary biological activity studies show that the Zn(II)P has photo-toxicity on human chronic myelogenous leukemia cell (K562) and could cleave supercoiled DNA (pBR 322 DNA), while the Cu(II)P has inferior biological activity. "
3.	Cicatrix (Scar) 01/01/2017 - "SCAR 4 and 5 were both found to be capable of inhibiting the supercoiled DNA relaxation mediated by Top 1. Interaction studies showed that SCAR 4 and 5 can bind to DNA through electrostatic interactions while SCAR 6 is able to bind covalently to DNA. "
4.	Neoplasms (Cancer) 11/15/2002 - "Role of tumor suppressor p53 domains in selective binding to supercoiled DNA." 09/17/1999 - "Preferential binding of tumor suppressor p53 to positively or negatively supercoiled DNA involves the C-terminal domain." 08/01/1991 - "Interaction between ionizing radiation and supercoiled DNA within human tumor cells." 04/01/1982 - "Avian tumor virus supercoiled DNA was isolated from infected quail tumor cells and molecularly cloned in pBR322. " 10/26/2023 - "Topoisomerase 1 (Top1) is an essential enzyme involved in unwinding supercoiled DNA, and it serves as a key target for several anti-cancer drugs. "
5.	Infections 01/01/1980 - "Cleavage of superhelical DNA from a lambda pi B mutant phage was observed after infection of either strain whereas superhelical DNA from a wild type phage was only cleaved after infection of JG28. " 01/01/1979 - "Infectious supercoiled DNA could be recovered from 16 h after infection. " 06/01/2001 - "For the outcome of a hepatitis B virus (HBV) infection, the viral L envelope protein with its pre-S domain performs pivotal functions by mediating attachment of HBV to liver cells, envelopment of viral capsids, release of (sub)viral particles, regulation of supercoiled DNA amplification, and transcriptional transactivation. " 10/01/1980 - "With different doses of cycloheximide to cause different degrees of inhibition, the number of viral supercoiled DNA duplexes detected in the cells at 11 h showed an apparent correlation with the amount of progeny virus produced in the 12- to 22-h period of infection. " 08/15/2006 - "The results indicate that the acridine analogs bearing substituted carboxamides and bulky 9-amino functionalities are able to inhibit herpes infections as well as inhibit topoisomerase II relaxation of supercoiled DNA. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Type II DNA Topoisomerases (Topoisomerase II)
3.	Kinetoplast DNA (kDNA)
4.	Type I DNA Topoisomerases (Topoisomerase I)
5.	Proteins (Proteins, Gene)
6.	Enzymes
7.	A-Form DNA (A-DNA)
8.	Singlet Oxygen
9.	Antiviral Agents (Antivirals)
10.	Adenosine Triphosphate (ATP)

Related Therapies and Procedures

1.	Therapeutics