Increased serum cholesterol esterification rates predict coronary heart disease and sudden death in a general population.

Abstract

OBJECTIVE:

Lecithin:cholesterol acyltransferase (LCAT) is thought to be important in reverse cholesterol transport. However, its association with coronary heart disease (CHD) and sudden death is controversial.

APPROACH AND RESULTS:

We prospectively studied 1927 individuals from the general population. Serum concentrations of apolipoprotein A-I, A-II, B, C-II, C-III, E, and LCAT activity measured as a serum cholesterol esterification rate were evaluated. We documented 61 events of CHD and sudden death during 10.9 years of follow-up. After adjustment for age and sex, LCAT activity was significantly associated with the risk of CHD and sudden death (hazard ratio, 3.02; 95% confidence interval, 1.49-6.12; P=0.002). In multivariate analysis adjusted for age, sex, current smoking status, history of diabetes mellitus, body mass index, systolic blood pressure, serum total cholesterol, and serum high-density lipoprotein cholesterol concentrations, the hazard ratio of LCAT activity for the risk of CHD and sudden death remained significant (hazard ratio, 3.07; 95% confidence interval, 1.35-7.01; P=0.008). However, when it was analyzed for men and women separately, this association remained significant only in women.

CONCLUSIONS:

Increased LCAT activity measured as a serum cholesterol esterification rate was a risk for CHD and sudden death in a Japanese general population.

• Authors: Shin-ichiro Tanaka, Tomoyuki Yasuda, Tatsuro Ishida, Yoshio Fujioka, Takeshi Tsujino, Tetsuo Miki, Ken-ichi Hirata
• Journal: Arteriosclerosis, thrombosis, and vascular biology (Arterioscler Thromb Vasc Biol) Vol. 33 Issue 5 Pg. 1098-104 (May 2013) ISSN: 1524-4636 [Electronic] United States
• PMID: 23430610 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cholesterol Esters
• Phosphatidylcholine-Sterol O-Acyltransferase

Topics

• Adult
• Aged
• Cholesterol Esters (blood)
• Coronary Disease (blood, etiology)
• Death, Sudden (etiology)
• Female
• Humans
• Male
• Middle Aged
• Phosphatidylcholine-Sterol O-Acyltransferase (metabolism)
• Prospective Studies
• Sex Characteristics