Cardiac Sudden Death (Sudden Cardiac Arrest)

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1699 relevant articles (101 outcomes, 252 trials/studies) found for this Disease

Description: Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)

Also Known As:

Sudden Cardiac Arrest; Death, Sudden Cardiac; Sudden Cardiac Death; Death, Sudden, Cardiac; Cardiac Arrest, Sudden; Arrest, Sudden Cardiac; Cardiac Arrests, Sudden; Cardiac Death, Sudden; Death, Cardiac Sudden; Sudden Death, Cardiac

Relationship Network

Disease Context: Research Results

Cardiovascular Diseases: 20552

Heart Diseases: 13044

Heart Arrest: 7856

Cardiac Sudden Death: 1699

Signs and Symptoms Pathological Conditions

Pathologic Processes: 2442

Death: 1282

Sudden Death: 2865

Cardiac Sudden Death: 1699

Related Diseases

1.	Myocardial Infarction
2.	Ventricular Tachycardia
3.	Cardiac Arrhythmias (Arrythmia)
4.	Heart Failure
5.	Ventricular Fibrillation

Experts

1.	Bardy, Gust H: 6 articles (10/2008 - 08/2002)
2.	Anderson, Jill: 5 articles (10/2008 - 07/2006)
3.	Mark, Daniel B: 5 articles (10/2008 - 07/2006)
4.	Lee, Kerry L: 5 articles (10/2008 - 07/2006)
5.	Poole, Jeanne E: 5 articles (10/2008 - 07/2006)
6.	Boriani, Giuseppe: 5 articles (07/2007 - 11/2006)
7.	Marks, Andrew R: 4 articles (06/2008 - 07/2002)
8.	Nakajima, Yasuhiro: 4 articles (05/2008 - 05/2004)
9.	Nakajima, Katsuyuki: 4 articles (05/2008 - 05/2004)
10.	Takeichi, Sanae: 4 articles (05/2008 - 05/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cardiac Sudden Death:

1.	Amiodarone (Amiodarona)FDA LinkGeneric 08/01/1995 - "Left ventricular ejection fraction < or = 0.27 and amiodarone treatment were related to greater cardiac mortality and increased risk of sudden cardiac death, whereas beta-blockade was associated with improved survival. " 11/04/1997 - "BACKGROUND: Some randomized clinical trials of amiodarone therapy to prevent sudden cardiac death have had positive results and others have had negative results, but all were relatively small. " 05/01/2009 - "Amiodarone for the prevention of sudden cardiac death: a meta-analysis of randomized controlled trials." 12/01/2002 - "The conflicting results of GESICA and CHF-STAT studies do not support a strategy of "prophylactic" amiodarone therapy in patients with DCM in order to prevent sudden cardiac death. " 11/04/1997 - "Quantitative overview of randomized trials of amiodarone to prevent sudden cardiac death." Order ALL the reference details at left...
2.	Omega-3 Fatty Acids (Omega 3 Fatty Acids)FDA Link 07/01/2003 - "Furthermore, the recent GISSI-Prevention study of 11 324 patients showed a marked decrease in risk of sudden cardiac death as well as a reduction in all-cause mortality in the group taking a highly purified form of omega-3 fatty acids, despite the use of other secondary prevention drugs, including beta-blockers and lipid-lowering therapy. " 09/13/2007 - "This assertion is substantiated by statistical data on sudden cardiac death and by the results of interventional studies on omega-3 fatty acids. " 01/01/2006 - "Based on the present knowledge about the relationship between blood levels of omega-3 fatty acids and sudden cardiac death obtained from studies of 14,000 individuals, a subject with an index below 50 should be advised to increase his/her intake of omega-3 fatty acids. " 07/01/2005 - "The data suggest that the protection offered by n-3 PUFA against sudden cardiac death observed in previous studies is mediated by a direct antiarrhythmic effect of n-3 PUFA." 06/01/2000 - "The recent GISSI (Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico)-Prevention study of 11,324 patients showed a 45% decrease in risk of sudden cardiac death and a 20% reduction in all-cause mortality in the group taking 850 mg/d of omega-3 fatty acids. " Order ALL the reference details at left...
3.	Anti-Arrhythmia AgentsIBA 09/01/1984 - "The development of four new antiarrhythmic drugs offers promise for the treatment of patients who survive an episode of sudden cardiac death. " 11/01/1985 - "[Efficacy of anti-arrhythmia agents for the prevention of cardiac sudden death]" 09/01/2002 - "Overview of randomized trials of antiarrhythmic drugs and devices for the prevention of sudden cardiac death." 04/15/1997 - "During recent years a number of controlled randomised trials have been published showing no or a harmful effect of antiarrhythmic drugs on the prognoses of patients at risk of sudden cardiac death. " 11/26/1993 - "Several studies have demonstrated that class I antiarrhythmic drugs do not reduce, and may increase, sudden cardiac death mortality and total cardiac mortality. " Order ALL the reference details at left...
4.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 01/01/2004 - "Secondary prevention of sudden cardiac death after cardiac events is based on betablockers, ACE inhibitors and antilipemic therapy. " 01/01/2003 - "Most anti-hypertensive therapies, such as the beta blockers or ACE inhibitors, by slowing or interrupting the progression towards atrial and ventricular remodelling might exert some anti-arrhythmic effect, thus reducing the risk of sudden cardiac death in these patients." 12/05/2000 - "Although beta-blockers, angiotensin-converting enzyme inhibitors, and revascularization play a role in prevention of sudden cardiac death, the development and subsequent refinement of the implantable cardioverter-defibrillator has made the most important contribution to its management. " 01/01/1996 - "The prolongation of life in heart failure patients treated with ACE-inhibitors might either derive from retarding the progression of heart failure (CONCENSUS I) or from reducing sudden cardiac death (VHeFT II-trial). " 04/01/1999 - "Patients with class I-IV heart failure treated with ACE inhibitors have fewer recurrent infarctions, a lower incidence of severe congestive heart failure, and a reduced incidence of total cardiovascular death and sudden cardiac death. " Order ALL the reference details at left...
5.	CalciumIBA 01/01/1991 - "Thus, calcium antagonists that exert direct myocardial actions may prove to be particularly effective in the prevention of sudden cardiac death in patients. " 01/01/2006 - "Over the past 5 years, various clinical studies have confirmed the predictive value of the coronary calcium score for both soft (revascularization, MI) and hard (MI and sudden cardiac death) events incrementally and independently of traditional coronary risk factors identified by the Framingham Heart Study. " 08/01/2008 - "As will be discussed, these changes promote the prolongation of the action potential, the enhancement of spatio-temporal gradients of repolarization, the formation of calcium-mediated triggers and conduction abnormalities, all of which combine to form an electrophysiological substrate that is ripe for the genesis of lethal arrhythmias and sudden cardiac death." 04/24/2003 - "Can coronary calcium calculation prevention sudden cardiac death?]" 01/01/1998 - "Of the reported (17 worldwide) patients with documented vasospasm-mediated sudden cardiac death treated with calcium blockers, none have had a recurrent event. " Order ALL the reference details at left...
6.	Fatty Acids (Saturated Fatty Acids)IBA 06/01/2003 - "A brief review of three clinical trials that suggest that these PUFAs prevent sudden cardiac death is also included in order to emphasize the potential importance of these fatty acids in human nutrition. " 11/01/2009 - "Intake of total trans, trans-18:1, and trans-18:2 fatty acids and risk of sudden cardiac death in women." 04/01/2008 - "Epidemiological data indicate that there is a strong association between intake of trans-18 : 2 fatty acids (TFA) and sudden cardiac death. " 01/01/2008 - "The recent literature shows an increase of intervention studies to learn if the fish oil fatty acids can reduce mortality from sudden cardiac death, and the mechanism(s) of such a protective effect. " 07/18/2006 - "CONCLUSIONS: Higher levels of trans-18:2 and lower levels of trans-18:1 fatty acids are associated with higher risks of fatal IHD and sudden cardiac death. " Order ALL the reference details at left...
7.	Lipoproteins (Lipoprotein)IBA 05/01/2008 - "Plasma remnant-like lipoprotein particles or LDL-C as major pathologic factors in sudden cardiac death cases." 03/01/2001 - "[Association of plasma triglyceride-rich lipoprotein remnants with sudden cardiac death]" 03/01/2005 - "Benefits include lower risk of primary cardiac arrest; reduced cardiovascular mortality, particularly sudden cardiac death; reduced triglyceride levels; increased high-density lipoprotein levels; improved endothelial function; reduced platelet aggregability; and lower blood pressure. " 10/01/2007 - "We have previously reported that plasma levels of remnant-like lipoprotein particles (RLP) significantly increased in sudden cardiac death cases with and without coronary atherosclerosis. " 02/01/1999 - "Association of plasma triglyceride-rich lipoprotein remnants with coronary atherosclerosis in cases of sudden cardiac death." Order ALL the reference details at left...
8.	Sotalol (Sotalol Hydrochloride)FDA LinkGeneric 01/01/2000 - "Sotalol had no influence at all on sudden cardiac death, while all the other beta-blockers referred to above have a very marked effect on sudden cardiac death, in fact more marked than on overall mortality. " 11/01/1996 - "Four patients had sudden cardiac death; three of these deaths occurred within the first month, and the last episode of sudden death occurred after 8 years of sotalol therapy. " 07/07/1994 - "As compared with other antiarrhythmic agents, sotalol prevents recurrences of arrhythmia in a higher proportion of patients, particularly among those presenting with ventricular tachycardia and aborted sudden cardiac death. " 08/01/1993 - "A study comparing amiodarone and sotalol in high-risk patients for sudden cardiac death is also needed. " 01/01/1992 - "The known pharmacological profiles and limited controlled clinical studies make amiodarone and sotalol promising candidates for drugs that may improve survival of patients at risk for sudden cardiac death." Order ALL the reference details at left...
9.	azimilideIBA 03/19/1998 - "Azimilide is expected to provide a unique new therapy for the prevention of supraventricular arrhythmias and sudden cardiac death when Phase III clinical trials are complete and safety and efficacy are confirmed." 02/01/2000 - "Azimilide also demonstrated antifibrillatory efficacy in a canine model of sudden cardiac death. " 03/19/1998 - "Sample size is based on the assumption that the all-cause mortality rate (the primary endpoint) for 1 year in placebo patients at high risk for sudden cardiac death (heart rate variability < or = 20 U) is 15% and that azimilide will decrease all-cause mortality by at least 45% in these patients. " 12/01/1993 - "The electrophysiologic and antifibrillatory properties of NE-10064 were studied in vivo in a conscious canine model of sudden cardiac death. " 12/01/1993 - "Protection against programmed electrical stimulation-induced ventricular tachycardia and sudden cardiac death by NE-10064, a class III antiarrhythmic drug." Order ALL the reference details at left...
10.	HDL CholesterolIBA 02/01/2005 - "CONCLUSIONS: Sudden cardiac death was correlated with atherosclerotic heart disease and nephropathy, and to a lesser degree with DAN and HDL cholesterol. " 07/13/1998 - "METHODS: Using nested case-control design and logistic regression analysis, we estimated the association between serum immunoglobulins and the risk of coronary end points (nonfatal or fatal myocardial infarction or sudden cardiac death) in dyslipidemic men (levels of non-high-density lipoprotein cholesterol >5.2 mmol/L [>201 mg/dL]) participating in the Helsinki Heart Study. " 08/01/2000 - "In intervention trials it was without exception possible to influence the development of atherosclerosis by a reduction of the LDL-cholesterol and an increase in HDL-cholesterol and to reduce complications like myocardial infarction, sudden cardiac death, angina or heart failure. " 10/01/2009 - "In a Cox model adjusting for other coronary risk factors (age, systolic blood pressure, smoking, diabetes, serum low-density lipoprotein and high-density lipoprotein cholesterol, body mass index, and exercise-induced myocardial ischemia), men with the D/D or I/D genotype had 1.97 times (95% CI 1.08-3.59, P = .026) higher risk to experience sudden cardiac death (20 events for D/D genotype, 13 events for I/I genotype, and 43 events for I/D genotype) compared with men carrying the I/I genotype. " 12/01/2001 - "For 5608 men and 997 postmenopausal women without clinical evidence of cardiovascular disease (CVD) who had average low-density lipoprotein cholesterol (LDL-C) and below average high-density lipoprotein cholesterol (HDL-C), 20-40 mg/day lovastatin reduced first acute major coronary events (AMCEs) 37% (for those receiving placebo and lovastatin, respectively, 183 and 116 first AMCEs defined as fatal or nonfatal myocardial infarction [MI], unstable angina, or sudden cardiac death; relative risk [RR] 0.63; 95% confidence interval [95% CI] 0.50, 0.79; p < 0.001). " Order ALL the reference details at left...

Therapies and Procedures

1.	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 07/01/2006 - "Implantable cardioverter defibrillators (ICDs) have been proven to be highly efficacious in protecting very high-risk cardiac patients from sudden cardiac death and hence enhancing their overall survival. " 11/01/2000 - "The implantable cardioverter defibrillator (ICD) is highly effective in the treatment of ventricular arrhythmias (VA) responsible for sudden cardiac death. " 01/01/1997 - "OBJECTIVE: The implantable cardioverter-defibrillator (ICD) has dramatically improved survival rates following sudden cardiac death episodes. " 01/01/1993 - "Implantable cardioverter defibrillators have dramatically improved survival rates for patients at risk of sudden cardiac death, but the occurrence of inappropriate shocks remains an unresolved problem. " 08/01/2009 - "The implantable cardioverter defibrillator remains the only therapeutic option of proven efficacy for primary and secondary prophylaxis of sudden cardiac death. " Order ALL the reference details at left...
2.	Defibrillators (Defibrillator) 06/01/1989 - "Thus both subendocardial resection and defibrillator implantation are highly effective in preventing sudden cardiac death. " 12/01/1994 - "The cardioverter defibrillator therapy has proven to be effective in preventing sudden cardiac death. " 08/01/2004 - "Implantable cardiac defibrillators (ICDs) are beneficial for certain patient groups with a history of serious, recurrent ventricular dysrhythmias, with a high risk of sudden cardiac death. " 12/01/2008 - "Surgery and, more recently, implantable cardiac defibrillators have had an impact on sudden cardiac death rates, with improved short- and medium-term survival. " 04/07/1998 - "Public access defibrillation (PAD) is a novel treatment for out-of-hospital sudden cardiac arrest that refers to use of automated external defibrillators by the lay public or by nonmedical personnel such as police. " Order ALL the reference details at left...
3.	Cardiopulmonary Resuscitation (CPR) 10/10/1994 - "Selective use of CPR in the hospital and community training in the use of these new adjunctive techniques should have the greatest impact on improved survival after sudden cardiac arrest." 12/01/2003 - "STUDY OBJECTIVE: Dispatcher-assisted telephone cardiopulmonary resuscitation (CPR) instruction can increase the proportion of sudden cardiac arrest victims who receive bystander CPR and has been associated with improved survival. " 05/01/2006 - "BACKGROUND: The efficacy of cardiopulmonary resuscitation (CPR) is vital for saving lives of victims with sudden cardiac arrest. " 01/01/2008 - "INTRODUCTION: The purpose of this study was to investigate the costs and health status outcomes of intensive care unit (ICU) admission in patients who present after sudden cardiac arrest with in-hospital or out-of-hospital cardiopulmonary resuscitation. " 11/01/2006 - "This is the first study to document the ability of middle school students to learn and retain CCC-CPR and AED skills for adult sudden cardiac arrest victims with such a curriculum." Order ALL the reference details at left...
4.	Resuscitation 11/01/2005 - "There has been considerable interest in analysis of the surface electrocardiogram (ECG) in VF centred on attempts to understand the pathophysiological processes occurring in sudden cardiac death, predicting the efficacy of therapy, and guiding the use of alternative or adjunct therapies to improve resuscitation success rates. " 01/01/2004 - "There has been considerable interest in analysis of the surface electrocardiogram (ECG) in VF centred on attempts to understand the pathophysiological processes occurring in sudden cardiac death, predicting the efficacy of therapy, and guiding the use of alternative or adjunct therapies to improve resuscitation success rates. " 12/01/2006 - "HYPOTHESIS: This study examined a population of nonselected patients presenting to a community hospital following successful resuscitation of sudden cardiac death. " 09/02/2006 - "BACKGROUND AND OBJECTIVE: The aims of the present study were to analyze the prognosis after resuscitation from out-of-hospital sudden cardiac death in patients admitted to the coronary care unit, and to identify the predictor variables of morbi-mortality. " 04/01/1998 - "OBJECTIVE: To study the circumstances and medical profile of out-of-hospital sudden cardiac arrest (SCA) patients in whom resuscitation was attempted by the ambulance service, and to identify causes of SCA in survivors and factors that influence resuscitation success rate. " Order ALL the reference details at left...
5.	Drug Therapy (Chemotherapy) 11/26/1993 - "Antiarrhythmic drug therapy for the prevention of sudden cardiac death has been provided primarily on the basis of trial and error and in some instances based on ill-suited preclinical evaluations. " 10/01/1992 - "The study analysis will address differences in total mortality, cardiac mortality, and sudden cardiac death between patients receiving anti-arrhythmic drug therapy and those receiving placebo. " 07/01/2008 - "Two patients died of sudden cardiac death 10 and 14 days after the administration of the first chemotherapy cycle, respectively, but these deaths were not clearly treatment related. " 05/01/2008 - "The role of antiarrhythmic drug therapy for the prevention of sudden cardiac death." 11/01/2000 - "Anti-arrhythmic agents are not useful as prophylactic drug therapy for reducing mortality in patients at risk for sudden cardiac death. " Order ALL the reference details at left...

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