Barbiturates

07/01/2016 - "A total of 15 citations were identified; 2 citations looked at barbiturates alone; 1 found barbiturates effective in an emergency department setting at treating seizures and preventing return visits. "
11/01/1997 - "In contrast, barbiturates augment function of all types of GABAA receptors, and are ineffective in control of generalized absence seizures, but effective in control of many other seizure types. "
03/01/1988 - "Among the 14 patients, intravenous barbiturates, when administered with a loading dose followed by continuous infusion, were uniformly effective in aborting seizures and producing a burst-suppression EEG pattern. "
03/01/2006 - "Presently, however, there are no data that have unequivocally demonstrated the efficacy of barbiturates in the treatment of neonatal seizures. "
01/01/1993 - "A low incidence of seizures (13%) has been documented in one study using a preventive administration of barbiturates; however, this needs to be confirmed before in order to be recommended. "

08/01/1983 - "Seven patients with normal scintigraphic studies were being treated with barbiturates and hypothermia at levels that attenuated or completely suppressed EEG activity. "
01/01/2022 - "Guidelines recommend medical management involving sedation, hyperosmotic agents, barbiturates, hypothermia, and surgical intervention. "
04/01/2010 - "Current findings support that hypothermia should be initiated as soon as possible, for at least 48 h duration, and that outcome is worse when barbiturates are part of ICU management. "
10/01/2009 - "Very few (ie, 15 of 57; 26%) protocols were capable of distinguishing between direct cerebral protection by the barbiturates and an artifactual, hypothermia-related, effect. "
10/01/2009 - "Our goal was to test the hypothesis that-given the barbiturates' novel ability to reduce brain temperature-the high prevalence of reports describing cerebral protection by barbiturates in animal models are, in part, the result of inadvertent cerebral hypothermia. "

04/01/1983 - "Our experience suggests that barbiturates can be effective in lowering intracranial pressure in patients with otherwise unresponsive intracranial hypertension, and, by doing so, may decrease the mortality in a group of patients considered untreatable by the usual therapeutic modalities."
01/01/2021 - "We have also illustrated the application of these methods, in which they were used to estimate the efficacy of barbiturates prescribed during the first 24 h of an episode of intracranial hypertension. "
01/01/1989 - "Efficacy of barbiturates in the treatment of resistant intracranial hypertension in severely head-injured children."
01/01/1989 - "Efficacy of barbiturates in the treatment of resistant intracranial hypertension in severely head-injured children."
01/01/2016 - "An update on the RESCUEicp study, a randomised trial of DC versus advanced medical management (including barbiturates) for severe and refractory post-traumatic intracranial hypertension is provided. "

01/01/1991 - "Experiments were done to study the influence of the sedation in temporary threshold shift (TS) induced by acoustic overstimulation, as barbiturates were found to improve the brain's tolerance to ischemia. "
12/01/1996 - "The mechanism by which barbiturates protect neurons against ischemia is unclear, particularly when they are given after ischemia or reperfusion begins. "
09/01/1993 - "Conversely, in the event of incomplete ischemia EEG activity in usually present (albeit altered) and metabolic suppression and hence possibly protection can be induced with barbiturates. "
09/01/1989 - "Barbiturates for global and focal ischemia."
09/01/1984 - "The barbiturates have been shown to provide protection in focal ischemia and incomplete global ischemia in which neuronal function is still present, but have not been shown to provide protection following complete global ischemia. "

01/01/2014 - "Dosages were moderate, barbiturates were not used, medication induced burst-suppression not achieved, and treatment improved electroencephalographic status epilepticus patterns temporarily (<6 h). "
02/01/2016 - "Should Barbiturates be Used in Refractory Status Epilepticus?"
06/01/2006 - "We conclude that stimulus sensitivity may appear in the context of refractory status epilepticus treated with high-dose barbiturates. "
01/01/1987 - "[Treatment of status epilepticus in children with short-acting barbiturates]."
01/01/1983 - "Barbiturates in the treatment of status epilepticus."