Amides

Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant & Hackh's Chemical Dictionary, 5th ed)

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Networked: 2487 relevant articles (101 outcomes, 265 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zhou, Jinyuan: 61 articles (11/2023 - 08/2003)
2.	Zhang, Yi: 34 articles (03/2024 - 07/2015)
3.	Jiang, Shanshan: 32 articles (11/2023 - 07/2015)
4.	Sun, Phillip Zhe: 30 articles (12/2023 - 02/2007)
5.	Heo, Hye-Young: 26 articles (05/2024 - 07/2015)
6.	van Zijl, Peter C M: 20 articles (01/2022 - 08/2003)
7.	Wen, Zhibo: 17 articles (04/2024 - 01/2011)
8.	Lin, Liangjie: 16 articles (02/2024 - 01/2021)
9.	Zaiss, Moritz: 16 articles (12/2023 - 04/2014)
10.	Togao, Osamu: 14 articles (10/2023 - 01/2013)

Related Diseases

1.	Neoplasms (Cancer) 03/04/2023 - "In this study, GAA was modified at the carboxyl group to synthesize a series of amide compounds, and the in vitro anti-tumor activities of the derivatives were investigated. " 01/01/2022 - "For this purpose, previously identified anti-inflammatory compound i.e., Phenylcarbamoylpiperidine-1,2,4-triazole amide derivatives by our own group were selected for their anti-cancer potential via detailed Computational studies. " 04/15/2021 - "In our previous study, we demonstrated that the amide derivatives of pyxinol are promising modulators against Pgp-mediated MDR in cancer. " 03/05/2021 - "In this study, twenty-seven 3,4-dihydropyrimidin-2(1H)-one C5 amide derivatives were synthesized and their cancer cell growth inhibitory activity was examined against MCF-7, HT-29 and MOLT-4 cells and also NIH/3T3 non-cancer cells by MTT assay. " 10/01/2019 - "This study demonstrates, for the first time, that C-H stretching and amide I bands are of little to no significance in the classification of the colon malignancy, based on the Gini importance values by random forest (RF). "
2.	Pain (Aches) 12/01/2020 - "The evidence of the plasma stability of the amide-linked hybrids previously reported prompted us to investigate their pain-relieving mechanism of action. " 02/01/2020 - "Pharmacological potential of alkylamides from Acmella oleracea flowers and synthetic isobutylalkyl amide to treat inflammatory pain." 11/15/2017 - "The SP1-7 amide 1 (Arg1-Pro2-Lys3-Pro4-Gln5-Gln6-Phe7-NH2) was previously shown to be superior to the endogenous SP1-7 in all experimental pain models where the two compounds were compared. " 08/30/2017 - "The heptapeptide SP1-7 amide (2, Arg1-Pro2-Lys3-Pro4-Gln5-Gln6-Phe7-NH2) is often more efficacious than 1 in experimental pain models. " 10/01/1996 - "Amide local anaesthetics are commonly used to relieve surgical wound pain. "
3.	Seizures (Absence Seizure) 06/01/1984 - "For those N-alkyl amides tested, 4-amino-N- amylbenzamide (6) was the most potent against maximal electroshock seizures (MES): ED50 = 42.98 mg/kg; however, the N- cyclohexylbenzamide (8) showed the greatest protective index (PI = TD50/ED50), 2.8. " 04/01/1999 - "The amides (12-14) showed protection against MES and/or scMet seizures in mice. " 08/01/2021 - "DL-3-hydroxy-3-phenylpentanamide (HEPP) and DL-3-hydroxy-3-(4'chlorophenyl)-pentanamide (Cl-HEPP) are phenyl-alcohol-amides that are metabotropic GABAB receptor (MGBR) antagonists and protective against absence seizures. " 11/01/1995 - "2-(4-Phenylpiperazine)-4-phthalimidobutyric acid and three N-substituted amides of this acid displaced protection against MES and scMet-induced seizures." 11/01/2002 - "The present study investigates the activity of four gamma-hydroxybutyric acid amide analogues (BM-68, BM-74, BM-75 and BM-76) in two models of chemically induced seizures, i.e. "
4.	Body Weight (Weight, Body) 01/01/2018 - "Administration of (Lys8GluPAL)apelin-13 amide and pGlu(Lys8GluPAL)apelin-13 amide for 28 days significantly reduced food intake and decreased body weight. " 03/01/2005 - "Structure-activity relationship studies directed toward the optimization of 4,5-diarylimidazole-2-carboxamide analogs as human CB1 receptor inverse agonists resulted in the discovery of the two amide derivatives 24a and b (hCB1 IC50 = 6.1 and 4.0 nM) which also demonstrated efficacy in overnight feeding studies in the rat for reduction in both food intake and overall body weight." 01/01/2019 - "Novel nonapeptide GLP (28-36) amide derivatives with improved hypoglycemic and body weight lowering effects." 12/01/2020 - "pGlu(Lys8 Glu-PAL)apelin-13 amide treatment partly reversed body weight loss induced by STZ and normalized circulating insulin. " 05/15/2007 - "Further optimization provided the imidazole 2-hydroxy-cyclohexyl amide 45, which exhibited hCB-1 K(i)=3.7nM, and caused significant appetite suppression and robust, dose-dependent reduction of body weight gain in industry-standard rat models."
5.	Glioma (Gliomas) 11/08/2023 - "In conclusion, our study not only identified GA-amide as an effective and safe agent for treating glioma but also shed light on the underlying mechanisms of GA-amide from the perspective of cytoskeletal homeostasis." 05/15/2024 - "Maps of Guan and amide CEST derived from 3DSOS were demonstrated on a low-grade glioma patient. " 10/01/2014 - "Amide exchange could be detected with lower saturation power than has previously been reported in glioma, but it was a weak signal source with no detectable contrast from normal brain tissue. " 11/08/2023 - "Moreover, GA-amide exhibited significant efficacy in inhibiting tumor growth across various in vivo glioma models, encompassing transgenic and primary patient-derived xenograft (PDX) models. " 10/09/2020 - "MATERIAL AND METHODS FTIR was used to investigate the morphological and biochemical properties of human astrocytes (HA), microglia (HM1900), glioma cells (U87), and glioblastoma cells (BT325) cultured in vitro to simulate the infiltration area, with the use of multi-peak fitting and principal component analysis (PCA) of amide I of FTIR spectra and the use of hierarchical cluster analysis (HCA). "

Related Drugs and Biologics

1.	Protons (Proton)
2.	Fatty Acids (Saturated Fatty Acids)
3.	Esters
4.	APT
5.	Peptides (Polypeptides)
6.	Insulin (Novolin)
7.	Prodrugs
8.	Proteins (Proteins, Gene)
9.	Local Anesthetics
10.	Glucagon-Like Peptide 1 (GLP 1)

Related Therapies and Procedures

1.	Therapeutics
2.	Punctures
3.	Photochemotherapy (Photodynamic Therapy)
4.	Oral Administration
5.	Intravenous Infusions