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Local Anesthetics

Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
Also Known As:
Anesthetics, Local; Anesthetics, Topical; Anesthetic, Local; Anesthetics, Conduction Blocking; Conduction Blocking Anesthetics; Topical Anesthetics; Anesthetics, Conduction-Blocking; Conduction-Blocking Anesthetics; Local Anesthetic
Networked: 5966 relevant articles (576 outcomes, 786 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Manchikanti, Laxmaiah: 86 articles (01/2022 - 01/2002)
2. Pampati, Vidyasagar: 59 articles (01/2022 - 01/2002)
3. Cash, Kimberly A: 44 articles (11/2020 - 05/2007)
4. Singh, Vijay: 31 articles (01/2015 - 01/2002)
5. Falco, Frank J E: 26 articles (01/2015 - 03/2008)
6. McManus, Carla D: 23 articles (01/2015 - 07/2004)
7. Hirsch, Joshua A: 22 articles (01/2022 - 10/2003)
8. Ilfeld, Brian M: 21 articles (01/2022 - 06/2002)
9. Kaye, Alan D: 19 articles (01/2022 - 04/2013)
10. Knezevic, Nebojsa Nick: 14 articles (01/2022 - 05/2011)

Related Diseases

1. Pain (Aches)
2. Postoperative Pain
3. Wounds and Injuries (Trauma)
4. Neuralgia (Stump Neuralgia)
5. Low Back Pain (Lumbago)

Related Drugs and Biologics

1. Steroids
2. Analgesics (Analgesic Drugs)
3. Opioid Analgesics (Opioids)
4. Lidocaine (Xylocaine)
5. Bupivacaine (Bupivacaine Hydrochloride)
6. Anesthetics (Anesthetic Agents)
7. Adrenal Cortex Hormones (Corticosteroids)
8. Ropivacaine (Naropin)
9. Dexmedetomidine
10. Carticaine (Articaine)

Related Therapies and Procedures

1. Analgesia
2. Injections
3. Epidural Injections
4. Nerve Block (Nerve Blocks)
5. Catheters