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aegeline

main alkaloid of aegle Marmelos correa leaves; structure in first source

Also Known As:

N-(2-hydroxy-2(4-methoxyphenyl)ethyl)-3-phenyl-2-propenamide

Networked: 9 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 140
- Amides: 2487
  - aegeline: 9

Experts

1.	Narender, Tadigoppula: 2 articles (01/2018 - 09/2015)
2.	Narender, T: 2 articles (11/2011 - 03/2007)
3.	Shah, Bhagyabhumi: 1 article (05/2024)
4.	Solanki, Nilay: 1 article (05/2024)
5.	Chen, Ji: 1 article (04/2024)
6.	Chen, Xin: 1 article (04/2024)
7.	Dong, Mingxin: 1 article (04/2024)
8.	Liu, Xuequan: 1 article (04/2024)
9.	Zhang, Han-Ting: 1 article (04/2024)
10.	Zhang, Lu: 1 article (04/2024)

Related Diseases

1.	Insulin Resistance 01/01/2018 - "In our present study, we have evaluated the β3-AR activity of novel N-acyl-1-amino-3-arylopropanol synthetic mimics of aegeline and its beneficial effect in insulin resistance. " 01/01/2018 - "Aegeline inspired synthesis of novel β3-AR agonist improves insulin sensitivity in vitro and in vivo models of insulin resistance." 09/05/2015 - "Therefore, multiple targets of aegeline in the improvement of insulin sensitivity of the skeletal muscle cells may be suggested. "
2.	Obesity 04/01/2019 - "Preclinical studies have reported possible therapeutic potential for aegeline against obesity and diabetes. "
3.	Hypercholesterolemia 01/01/2019 - "LOX-1, the Common Therapeutic Target in Hypercholesterolemia: A New Perspective of Antiatherosclerotic Action of Aegeline." 01/01/2019 - "This study was planned to address whether aegeline (AG) could bind to LOX-1 with a higher affinity and modulate the uptake of Ox-LDL in hypercholesterolemia. "
4.	Colitis 05/20/2024 - "Aegeline attenuates TNBS-induced colitis by suppressing the NFƙB-mediated NLRP3 inflammasome pathway in mice." 05/20/2024 - "Suggestive of the findings, aegeline reduced the damage to the colon by downregulating transcriptional genes and enzymes leading to inflammation and mitigated TNBS-induced colitis probably through the NFƙB-mediated NLRP3 inflammasome pathway." 05/20/2024 - "The study aimed to investigate the effectiveness of aegeline in alleviating 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis through the NFƙB-mediated NLRP3 inflammasome pathway. "
5.	Ischemic Stroke 04/24/2024 - "Our study discovered the neuroprotective effect of aegeline as a novel PAM targeting GluN1/2A NMDAR, which provides a potential opportunity for the development of therapeutic agents for ischemic stroke."

Related Drugs and Biologics

1.	Inflammasomes
2.	Neuroprotective Agents
3.	Sulfonic Acids
4.	oxidized low density lipoprotein
5.	sym-trinitrobenzene
6.	Hypoglycemic Agents (Hypoglycemics)
7.	Amides
8.	Cytokines
9.	Triglycerides (Triacylglycerol)
10.	Sucrose (Saccharose)