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1- (1- (4- fluoro- 2- (2- oxopyrrolidin- 1- yl)phenyl)- 3- oxopiperidin- 4- ylcarbamoyl)cyclohexyl furan-2-carboxylic acid amide

a cathepsin K inhibitor; structure in first source

Also Known As:

OST 4077; OST-4077; OST4077

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - 1-(1-(4-fluoro-2-(2-oxopyrrolidin-1-yl)phenyl)-3-oxopiperidin-4-ylcarbamoyl)cyclohexyl furan-2-carboxylic acid amide: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Furans: 85
    - 1-(1-(4-fluoro-2-(2-oxopyrrolidin-1-yl)phenyl)-3-oxopiperidin-4-ylcarbamoyl)cyclohexyl furan-2-carboxylic acid amide: 1

Experts

1.	Ahn, B N: 1 article (08/2006)
2.	Bae, M H: 1 article (08/2006)
3.	Choi, H: 1 article (08/2006)
4.	Chong, W: 1 article (08/2006)
5.	Han, T D: 1 article (08/2006)
6.	Huh, Y: 1 article (08/2006)
7.	Kim, H D: 1 article (08/2006)
8.	Kim, H J: 1 article (08/2006)
9.	Kim, M K: 1 article (08/2006)
10.	Kim, S H: 1 article (08/2006)

Related Diseases

1.	Osteoporosis 08/01/2006 - "OST-4077, an orally active selective human cathepsin K inhibitor, may have the therapeutic potential for the treatment of diseases characterized by excessive bone loss including osteoporosis."
2.	Bone Resorption 08/01/2006 - "Parathyroid hormone-induced bone resorption was inhibited in a dose-dependent manner in thyroparathyroidectomized rats gavaged with a single dose of OST-4077 (ED50, 69 mg/kg). " 08/01/2006 - "OST-4077 suppressed bone resorption induced by rabbit osteoclasts (IC50, 37 nM) but did not affect bone mineralization or cellular alkaline phosphatase activity in MC3T3-E1 cells. "

Related Drugs and Biologics

1.	Cathepsin K
2.	Parathyroid Hormone (Parathormone)
3.	Alkaline Phosphatase