Cold Urticaria

Various skin flares developing after exposure to cold temperature. While most are characterized by a limited episodic cutaneous condition characterized by URTICARIAL WHEALS, such as in allergic urticaria, other types are more severe and generalized and rarely familial, e.g., cryopyrin-associated periodic syndromes.

Also Known As:

Networked: 208 relevant articles (13 outcomes, 27 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Chronic Urticaria
2.	Anaphylaxis (Anaphylactic Shock)
3.	Erythema
4.	Urticaria (Hives)
5.	Familial dermographism

Experts

1.	Maurer, Marcus: 15 articles (01/2022 - 03/2009)
2.	Metz, Martin: 7 articles (12/2021 - 01/2010)
3.	Maurer, M: 5 articles (03/2018 - 12/2007)
4.	Krause, Karoline: 4 articles (01/2021 - 01/2011)
5.	Giménez-Arnau, Ana: 4 articles (07/2019 - 01/2010)
6.	Zuberbier, Torsten: 4 articles (01/2018 - 09/2002)
7.	Altrichter, Sabine: 3 articles (01/2022 - 01/2011)
8.	Bizjak, Mojca: 3 articles (01/2022 - 01/2021)
9.	Terhorst-Molawi, Dorothea: 3 articles (01/2022 - 01/2021)
10.	Church, Martin K: 3 articles (07/2019 - 03/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cold Urticaria:

1.	Omalizumab (Xolair)FDA Link 08/01/2019 - "The cold urticaria patient gained complete symptom relief 10 days after the first dose of omalizumab; the quality of life improved substantially with no side effects of the treatment. " 01/01/2017 - "Omalizumab is effective in cold urticaria-results of a randomized placebo-controlled trial." 08/01/2013 - "Effective treatment of idiopathic chronic cold urticaria with omalizumab: report of 3 cases." 01/01/2022 - "Cold urticaria was managed by H1-antihistamines in 95.67% (95% CI, 92.47% to 97.54%; I2 = 38%) of patients and omalizumab in 5.95% (95% CI , 2.55% to 13.27%; I2 = 83%) of patients. " 12/01/2021 - "Omalizumab in cold urticaria in children: Retrospective case series of 13 patients, review of the literature."
2.	Histamine (Histamine Dihydrochloride)FDA Link 01/01/1989 - "These results suggest that alpha-FMH may be useful in the treatment of severe cold urticaria especially in combination with histamine exhaustion of mast cells using cold water." 01/01/2012 - "Cold urticaria patients exhibit normal skin levels of functional mast cells and histamine after tolerance induction." 09/01/1995 - "In the cold urticaria patients, an up to 80-fold increase of histamine was observed, with peak levels 20-30 min after challenge. " 01/01/1994 - "The investigations demonstrated that the test was always positive in cold urticaria and that a high percentage of patients had a rise in blood histamine. " 01/01/1992 - "Blood histamine levels following graded cold challenge in atypical acquired cold urticaria."
3.	Histamine Antagonists (Antihistamines)IBA 01/01/2023 - "Cold urticaria was considered, and the patient was prescribed nonsedating antihistamines for a week. " 01/01/2016 - "Second-generation H1 antihistamines are the first line of treatment in cold urticaria; however, patients who are unresponsive to initial treatment with H1 antihistamines may require further management options. " 05/01/2012 - "Critical temperature threshold measurement for cold urticaria: a randomized controlled trial of H(1) -antihistamine dose escalation." 06/01/2010 - "Efficacy and tolerability of second- and third-generation antihistamines in the treatment of acquired cold urticaria: a meta-analysis." 04/01/2003 - "Treatment of primary acquired cold urticaria (CU) is quite difficult because of variable clinical effectiveness and side effects of classic antihistamines. "
4.	IceIBA 11/01/2004 - "Cold urticaria following an ice application: a case study." 09/01/2002 - "Patients with a negative ice cube test may have represented systemic cold urticaria (atypical acquired cold urticaria) induced by general body cooling. " 01/01/1996 - "We conclude that the diagnosis of cold urticaria can be based on history taking alone and the three ice cube tests (prognosis value, indication of reaction threshold). " 01/01/1996 - "Among these patients, 104 met the criteria for the diagnosis of cold urticaria: positive test with 3 ice cubes placed on the skin for 5, 10 and 15 minutes or positive immersion test (immersion in 4 degrees C water for 15 minutes). " 12/01/1992 - "In conclusion, the ice cube test should be performed for 3 to 5 minutes to diagnose cold urticaria in children. "
5.	Cyproheptadine (Periactin)FDA Link 04/01/1980 - "The role of cyproheptadine in the treatment of cold urticaria." 12/01/1971 - "Treatment of cold urticaria with cyproheptadine." 01/01/1981 - "[Therapy of cold urticaria with cyproheptadine (pizotifene) (author's transl)]." 04/01/1980 - "Histamine release in cold urticaria was studied before and after therapy with cyproheptadine to determine whether any effect upon histamine release could be distinguished from end-organ receptor-site blockade. " 04/01/1979 - "[Results of the treatment in cases of cold urticaria, cold pruritus and cold rhinitis with peritol (zyproheptadinhydrochlorid) (author's transl)]."
6.	rupatadineIBA 01/01/2016 - "Rupatadine 20 mg and 40 mg are Effective in Reducing the Symptoms of Chronic Cold Urticaria." 01/01/2016 - "In conclusion, rupatadine 20 and 40 mg significantly reduced the development of chronic cold urticaria symptom without an increase in adverse effects. " 01/01/2010 - "Rupatadine and its effects on symptom control, stimulation time, and temperature thresholds in patients with acquired cold urticaria." 09/01/2009 - "Treatment of acquired cold urticaria with rupatadine." 09/01/2013 - "This study evaluates the effectiveness and safety of rupatadine in chronic urticaria (CU) and acquired cold urticaria (ACU), through a systematic review of the literature. "
7.	Cetirizine (Zyrtec)FDA LinkGeneric 05/01/2005 - "The patient continues to present clinical manifestations of cold urticaria, although he has experienced some improvement and his tolerance to cold has increased after treatment with cetirizine." 10/01/2003 - "Treatment of acquired cold urticaria with cetirizine and zafirlukast in combination." 09/01/1992 - "The efficacy of the new nonsedating antihistamines loratadine and cetirizine was compared in a randomized, single-blind, crossover, controlled study with that of the classical antihistamines cyproheptadine and ketotifen in seven patients with primary acquired cold urticaria (ACU). " 01/01/2007 - "To study the significance of LTC4 vs. histamine, 6 patients with cold urticaria were challenged with the ice cube test before and after ingestion of 10 mg cetirizine (antihistamine), 10 mg montelukast (leukotriene antagonist) or a combination of both drugs. "
8.	Ketotifen (Ketotifene)FDA Link 12/01/1985 - "It is concluded that ketotifen may have a place in the treatment of primary acquired cold urticaria." 01/01/1984 - "[Treatment of acquired cold urticaria with ketotifen]." 06/01/1995 - "Our data demonstrated that ketotifen was as effective as cyproheptadine in the treatment of cold urticaria in Thai children." 06/01/1995 - "Cold urticaria in Thai children: comparison between cyproheptadine and ketotifen in the treatment." 07/01/1989 - "Terbutaline and ketotifen in cold urticaria in a child."
9.	Loratadine (Alavert)FDA Link 09/01/1992 - "The efficacy of the new nonsedating antihistamines loratadine and cetirizine was compared in a randomized, single-blind, crossover, controlled study with that of the classical antihistamines cyproheptadine and ketotifen in seven patients with primary acquired cold urticaria (ACU). "
10.	AstemizoleIBA 11/15/1986 - "20 patients, 12 suffering from chronic urticaria, 2 from acute urticaria, 1 from pressure urticaria, 2 from cold urticaria and 3 from urticaria factitia were treated in an open pilot study with the new H1-antihistamine Astemizole. " 11/15/1986 - "Astemizole proved in this study to be a very effective antihistamine being able to achieve good results even in hard to cure cases like cold urticaria. "

Therapies and Procedures

1.	Therapeutics 05/01/2012 - "Measurement of CTT allows for individualized risk management and therapy in patients with cold urticaria." 08/01/2005 - "Cold urticaria; disease course and outcome--an investigation of 85 patients before and after therapy." 10/01/2003 - "We tested this hypothesis in 2 patients with severe systemic cold urticaria poorly responsive to conventional therapy. " 11/01/2001 - "Therapy of cold urticaria may prove to be difficult. " 11/01/1983 - "Our results suggest that absorbable compounds that can inhibit mast cell degranulation may be efficacious in cold urticaria and of particular value in treating patients who do not respond to standard therapy."
2.	Cardiopulmonary Bypass (Heart-Lung Bypass) 01/28/1982 - "Management of cold urticaria during hypothermic cardiopulmonary bypass." 02/01/1988 - "We here report on a patient having a severe cold urticaria who because of angina required myocardial revascularization: She was successfully operated in normothermic cardiopulmonary bypass with cardioplegia." 11/01/1986 - "Possible etiologies include activation of complement anaphylatoxins during cardiopulmonary bypass, cardiac asthma, cold urticaria syndrome, exacerbation of preoperative bronchospastic disease, allergic reactions, drug-induced histamine release and beta-adrenergic blockade induced bronchospasm. "
3.	Cryotherapy (Therapy, Cold) 09/01/2013 - "A peculiar subset of cold urticaria secondary to exposure to ultra-freeze temperatures developing in patients treated with cryotherapy is reported. " 10/01/2021 - "Report of a Case of Cold Urticaria Following Cryotherapy - Need for Screening for Untoward Effects of Cryotherapy in Physical Therapy Clinical Practice."
4.	Cryosurgery 01/01/2023 - "Preoperative testing for tissue response to cryosurgery will prevent complications like cold urticaria. " 01/01/2023 - "Cold urticaria formation after applying cryosurgery has never been reported in the literature to the best of the authors' knowledge. " 01/01/2023 - "Iatrogenic cold urticaria induced by tetrafluoroethane cryosurgery for gingival depigmentation: A rare case report." 12/01/2019 - "We could demonstrate that cold urticaria can manifest as oesophageal angio-oedema in AF patients undergoing cryoablation. " 12/01/2019 - "Due to missing peri-atrial lesions, activation of cold urticaria during cryoablation rather than procedure-associated alterations was diagnosed. "
5.	Physical Therapy Modalities (Physical Therapy Technique) 10/01/2021 - "Report of a Case of Cold Urticaria Following Cryotherapy - Need for Screening for Untoward Effects of Cryotherapy in Physical Therapy Clinical Practice."