Klotho Proteins

Membrane bound glucuronidase enzymes that may play a role in activation of FIBROBLAST GROWTH FACTORS, and in the regulation of a variety of cell signaling pathways.

Also Known As:

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Gan, Lu: 1 article (09/2017)
2.	Zhou, Qiaoling: 1 article (09/2017)
3.	Benchetrit, Sydney: 1 article (08/2011)
4.	Bernheim, Jacques: 1 article (08/2011)
5.	Lafage-Proust, Marie-Hélène: 1 article (03/2010)

Related Diseases

1.	Chronic Renal Insufficiency 03/01/2010 - "Compared to normal tissue, hyperplastic parathyroid glands of patients with chronic kidney disease on dialysis express lower levels of FGFR1 and Klotho proteins. " 09/28/2017 - "To analyze the levels of serum calcium, phosphate, fibroblast growth factor 23 (FGF23), and Klotho proteins in patients with chronic kidney disease (CKD), and to investigate the correlations of FGF23 and Klotho proteins with cardiac complicates in patients with chronic kidney disease-mineral and bone disorder (CKD-MBD). Methods: A total of 180 CKD-MBD patients were enrolled for this study. "
2.	Chronic Kidney Disease-Mineral and Bone Disorder (Renal Rickets) 09/28/2017 - "To analyze the levels of serum calcium, phosphate, fibroblast growth factor 23 (FGF23), and Klotho proteins in patients with chronic kidney disease (CKD), and to investigate the correlations of FGF23 and Klotho proteins with cardiac complicates in patients with chronic kidney disease-mineral and bone disorder (CKD-MBD). Methods: A total of 180 CKD-MBD patients were enrolled for this study. "
3.	Neoplasms (Cancer) 10/31/2023 - "Further clinical development of Klotho-based assays will require careful identification of specific tumor subtypes where Klotho proteins may be most valuable as diagnostic or prognostic tools." 10/31/2023 - "Klotho proteins, αKlotho, βKlotho, and γKlotho, exert tumor-suppressive activities via the fibroblast growth factor receptors and multiple cell-signaling pathways. "
4.	Inflammation (Inflammations) 11/02/2022 - "While these results draw attention to potential relationships between α-Klotho proteins and inflammatory markers in HD patients, our cross-sectional study could not confirm the pathogenic link between α-Klotho, inflammation, and cardiovascular mortality."
5.	Hypertension (High Blood Pressure) 08/01/2011 - "In addition, the hormonal affect of circulating FGF23 and Klotho proteins on vascular reactivity, either directly on endothelial cell functions or indirectly by modulating the brain endothelin-1-dependent sympathetic nervous system activity, has contributed to understanding their role in the pathophysiology of hypertension and atherosclerotic vasculopathies. "

Related Drugs and Biologics

1.	Fibroblast Growth Factor-23
2.	calcium phosphate
3.	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)