Mitochondrial Permeability Transition Pore

A multiprotein inner mitochondrial complex which opens only under certain pathological conditions (e.g., OXIDATIVE STRESS) uncoupling the membrane leading to APOPTOSIS and MITOCHONDRIAL TRANSMEMBRANE PERMEABILITY-DRIVEN NECROSIS particularly in CARDIOMYOCYTES during MYOCARDIAL REPERFUSION INJURY.

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Networked: 807 relevant articles (24 outcomes, 68 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ovize, Michel: 28 articles (11/2020 - 01/2005)
2.	Yellon, Derek M: 15 articles (10/2014 - 12/2003)
3.	Bernardi, Paolo: 13 articles (01/2020 - 05/2007)
4.	Molkentin, Jeffery D: 12 articles (01/2021 - 09/2007)
5.	Gao, Qin: 11 articles (05/2018 - 01/2005)
6.	Xia, Qiang: 11 articles (03/2014 - 01/2005)
7.	Hausenloy, Derek J: 10 articles (01/2015 - 12/2003)
8.	Davidson, Sean M: 10 articles (10/2014 - 03/2006)
9.	Sahach, V F: 10 articles (01/2008 - 01/2002)
10.	Di Lisa, Fabio: 8 articles (01/2020 - 07/2002)

Related Diseases

1.	Ischemia 01/01/2017 - "Growing number of studies provide strong evidence that the mitochondrial permeability transition pore (PTP), a non-selective channel in the inner mitochondrial membrane, is involved in the pathogenesis of cardiac ischemia-reperfusion and can be targeted to attenuate reperfusion-induced damage to the myocardium. " 11/01/2016 - "The purpose of this study was to determine whether Zn2+ is involved in endoplasmic reticulum (ER) stress inhibition-induced cardioprotection against ischemia/reperfusion (I/R) injury by modulation of the mitochondrial permeability transition pore (mPTP) opening. " 02/01/2022 - "The opening of the mitochondrial permeability transition pore (PTP) has been proposed to play a critical role in activating cell death in many settings, including cardiac ischemia and reperfusion. " 01/01/2022 - "This was associated with the inhibition mitochondrial permeability transition pore opening and increased resistance of the isolated heart to ischemia/reperfusion in these animals. " 01/01/2021 - "We tested the hypothesis that 8-Br is also protective under clinically relevant conditions (regional ischaemia) when applied either before ischemia or at the beginning of reperfusion, and this effect is associated with the mitochondrial permeability transition pore (MPTP). "
2.	Mitochondrial Diseases (Mitochondrial Disease) 01/01/2023 - "In addition, SAHA treatment improved myocardial cell mitochondrial swelling inhibited mitochondrial membrane potential diminution and the openness of the mitochondrial permeability transition pore, and protected against mitochondrial dysfunction following I/R injury. " 02/15/2022 - "Targeting mitochondrial permeability transition pore ameliorates PM2.5-induced mitochondrial dysfunction in airway epithelial cells." 12/01/2017 - "Further investigation of the mechanisms demonstrated that thevetiaflavone decreases overproduction of ROS and ameliorates ROS‑mediated mitochondrial dysfunction, including collapse of mitochondrial membrane potential and mitochondrial permeability transition pore opening. " 11/01/2023 - "In this study, the results suggest that C12 (100 μM) induces upregulation of cytosolic and mitochondrial Ca+2 levels and triggers mitochondrial dysfunction through the generation of mitochondrial ROS (mROS), disruption of mitochondrial transmembrane potential (ΔΨm), and opening of the mitochondrial permeability transition pore (mPTP). " 01/01/2012 - "Recent biochemical studies implicate opening of the mitochondrial permeability transition pore (mPTP) in Aβ-mediated mitochondrial dysfunction. "
3.	Reperfusion Injury 08/01/2008 - "We tested our hypothesis that postischemic conditioning (PostC) is effective in salvage of ischemic skeletal muscle from reperfusion injury and the mechanism involves inhibition of opening of the mitochondrial permeability transition pore (mPTP). " 12/01/2015 - "The aims of this study were to evaluate whether the delayed application of low-pressure reperfusion could reduce lethal reperfusion injury and whether the inhibition of the opening of the mitochondrial permeability transition pore is involved in this protection. " 02/01/2008 - "4. The findings of the present study indicate that HSYA protects the myocardium against ischaemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening. " 12/01/2005 - "The aim of the present study was to determine whether the anti-ischemic agent TMZ might modulate mitochondrial permeability transition pore (mPTP) opening and limit lethal ischemia-reperfusion injury. " 12/01/2023 - "The essential role of the mitochondrial permeability transition pore in cell death coupled with the pro-survival function of SGK-1 raise the prospect that its therapeutic modulation could beneficially impact conditions associated with ischemia-reperfusion injury. "
4.	Myocardial Ischemia (Ischemic Heart Diseases) 01/12/2021 - "As it also acts on the opening of mitochondrial permeability transition pore (mPTP), CsA has been evaluated for ischemic heart diseases (IHD). " 01/01/2021 - "Mitochondrial permeability transition pore (mPTP) opening is a key event in cell death during myocardial ischemia reperfusion. " 06/01/2019 - "Increasing evidence has indicated that opening of the mitochondrial permeability transition pore (mPTP) has a vital role in myocardial ischemia/reperfusion (I/R) injury. " 05/20/2018 - "To investigate the role of mitochondrial permeability transition pore (MPTP) opening in mediating the effect of endomorphine-1 postconditioning to alleviate myocardial ischemia-reperfusion (IR) injury in rats. " 05/01/2018 - "Myocardial ischemia damages cardiac myocytes in part via opening of the mitochondrial permeability transition pore. "
5.	Hypoxia (Hypoxemia) 02/01/2014 - "This finding improves our understanding of the mechanism of mitochondrial permeability transition pore opening in cells in response to hypoxic preconditioning, and will be helpful in further developing new pharmacological agents targeting hypoxia-reoxygenation injury and mitochondria-mediated cell death. " 11/05/2021 - "In this study, we performed a series of interaction and colocalization assays and found that, after mitochondrial translocation, Drp1 may promote the excessive opening of the mitochondrial permeability transition pore (mPTP) after hypoxia. " 02/01/2022 - "Experiments on mitochondrial permeability transition pore (mPTP) using isolated mitochondria revealed that mitochondrial membrane was fragile in the Mg-deficient group, implying that cardiac function decline through hypoxia/reoxygenation injury is associated with mitochondrial function. " 11/25/2020 - "Following a prolonged exposure to hypoxia-reoxygenation, a partial disruption of the ER-mitochondria tethering by mitofusin 2 (MFN2) knock-down decreases the Ca2+ transfer between the two organelles limits mitochondrial Ca2+ overload and prevents the Ca2+-dependent opening of the mitochondrial permeability transition pore, i.e., limits cardiomyocyte cell death. " 09/01/2020 - "Hypoxia/reoxygenation exacerbates drug-induced cytotoxicity by opening mitochondrial permeability transition pore: Possible application for toxicity screening."

Related Drugs and Biologics

1.	Atractyloside
2.	5-hydroxydecanoic acid
3.	Cyclosporine (Ciclosporin)
4.	Adenosine Triphosphate (ATP)
5.	Phosphotransferases (Kinase)
6.	KATP Channels
7.	Leptin
8.	Reactive Oxygen Species (Oxygen Radicals)
9.	Cyclophilins (Cyclophilin)
10.	Caspase 3 (Caspase-3)

Related Therapies and Procedures

1.	Ischemic Postconditioning
2.	Endurance Training
3.	Percutaneous Coronary Intervention
4.	Induced Heart Arrest (Cardioplegia)
5.	Therapeutics