Leukocyte Immunoglobulin-like Receptor B1

A receptor for HISTOCOMPATIBILITY ANTIGENS CLASS I that also functions as a receptor for the UL18 protein, an MHC class I homolog expressed by human CYTOMEGALOVIRUS. It consists of four Ig-like C2 domains and is expressed primarily by B-cells and MONOCYTES, as well as DENDRITIC CELLS; its interaction with MHC1 functions to down-regulate the immune response.

Also Known As:

Networked: 57 relevant articles (0 outcomes, 7 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	López-Botet, Miguel: 4 articles (01/2020 - 10/2011)
2.	An, Zhiqiang: 3 articles (01/2021 - 01/2020)
3.	Arase, Hisashi: 3 articles (11/2020 - 12/2017)
4.	Kuśnierczyk, Piotr: 3 articles (06/2019 - 12/2016)
5.	Noyola, Daniel E: 3 articles (12/2018 - 12/2012)
6.	Muntasell, Aura: 3 articles (11/2013 - 10/2011)
7.	Fan, Jing: 2 articles (03/2022 - 01/2021)
8.	Gu, Aidong: 2 articles (03/2022 - 01/2021)
9.	Li, Jiayan: 2 articles (03/2022 - 01/2021)
10.	Song, Fangnan: 2 articles (03/2022 - 01/2021)

Related Diseases

1.	Malaria 12/07/2017 - "falciparum-infected erythrocytes isolated from patients with severe malaria were more likely to interact with LILRB1 than erythrocytes from patients with non-severe malaria, although an extended study with larger sample sizes is required to confirm this finding. " 11/01/2020 - "Structural basis for RIFIN-mediated activation of LILRB1 in malaria." 09/01/2006 - "Increase in annexin V-positive B cells expressing LILRB1/ILT2/CD85j in malaria." 01/01/2023 - "Repeated malaria exposure was associated with expansion of an atypical, CD56neg population of NK cells that differed transcriptionally, epigenetically, and phenotypically from CD56dim NK cells, including decreased expression of PLZF and the Fc receptor γ-chain, increased histone methylation, and increased protein expression of LAG-3, KIR, and LILRB1. "
2.	Disease Progression 11/01/2020 - "However, the regulatory mechanism of LILRB1 underlying the disease progression of adenocarcinoma remains vague. " 06/01/2018 - "In this study we investigated whether HLA-G, KIR2DL4, LILRB1 and LILRB2 polymorphisms may influence susceptibility to endometriosis and disease progression. "
3.	Rheumatoid Arthritis 08/15/2005 - "In this study, we screened for polymorphisms of LILRB1 and examined their association with SLE and rheumatoid arthritis (RA). " 01/01/2015 - "The paradox of high availability and low recognition of soluble HLA-G by LILRB1 receptor in rheumatoid arthritis patients." 08/15/2005 - "Extensive polymorphisms of LILRB1 (ILT2, LIR1) and their association with HLA-DRB1 shared epitope negative rheumatoid arthritis."
4.	Respiratory Syncytial Virus Infections 07/01/2015 - "Further studies are needed to define the role of LILRB1+ NK in response to RSV and to confirm an association between LILRB1 polymorphisms and the risk of severe RSV infection. " 07/01/2015 - "In this study the NK and T cell phenotypes, LILRB1 gene polymorphisms and KIR genotypes of infants hospitalized with RSV infection were analyzed. " 07/01/2015 - "Our results suggest that LILRB1 participates in the pathogenesis of RSV infection. " 07/01/2015 - "LILRB1 genotype distribution of the rs3760860 A>G, and rs3760861 A>G single nucleotide polymorphisms differed between infants with RSV infection and healthy donors, whereas no differences in any of the KIR genes were observed. "
5.	Liver Neoplasms (Liver Cancer) 03/24/2022 - "Our study revealed that the mRNA expression of LILRB1, LILRB2, LILRB3, and LILRB5 was downregulated, while compared with normal tissues, the mRNA expression of LILRB4 was upregulated in liver cancer tissues. "

Related Drugs and Biologics

1.	HLA-G Antigens (HLA G)
2.	Proteins (Proteins, Gene)
3.	Hypoxia-Inducible Factor 1
4.	Protein Isoforms (Isoforms)
5.	Messenger RNA (mRNA)
6.	DNA (Deoxyribonucleic Acid)
7.	Immunoglobulins (Immunoglobulin)
8.	Leukocyte Immunoglobulin-like Receptor B1
9.	Natural Killer Cell Receptors
10.	Ligands

Related Therapies and Procedures

1.	Immunotherapy
2.	Therapeutics
3.	Transplantation