Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein

A caspase-like cysteine endopeptidase that also exhibits ubiquitin ligase activity. It contains an N-terminal DEATH DOMAIN, two IMMUNOGLOBULIN-LIKE DOMAINS, and localizes to the perinuclear region of MONOCYTES, where it functions in activation of NF-KAPPA B; it also binds to and activates TRAF6. Chromosomal translocations involving the MALT1 and BIRC2 genes are associated with MALT LYMPHOMA, and mutations in the MALT1 gene are associated with Type 12 IMMUNODEFICIENCY SYNDROMES.

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Networked: 70 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Beyaert, Rudi: 8 articles (11/2018 - 03/2013)
2.	Hailfinger, Stephan: 6 articles (02/2022 - 01/2013)
3.	Krappmann, Daniel: 6 articles (11/2018 - 10/2009)
4.	Turvey, Stuart E: 5 articles (12/2021 - 11/2015)
5.	Bornancin, Frédéric: 5 articles (12/2020 - 04/2015)
6.	Staal, Jens: 5 articles (11/2018 - 07/2014)
7.	Schulze-Osthoff, Klaus: 4 articles (02/2022 - 04/2016)
8.	Lu, Henry Y: 4 articles (12/2021 - 01/2018)
9.	Régnier, Catherine H: 4 articles (12/2020 - 04/2015)
10.	Afonina, Inna S: 4 articles (11/2018 - 09/2015)

Related Diseases

1.	Neoplasms (Cancer) 06/15/2023 - "In contrast, stable silencing of endogenous MALT1 through RNA interference attenuates these aggressive cancer cell phenotypes, as well as migration, invasion, and tumor-forming ability, in poorly differentiated HCC cell lines with higher paracaspase expression. " 06/15/2023 - "MALT1 paracaspase is a druggable signaling molecule whose dysregulation has been linked to hematological and solid tumors. " 06/01/2023 - "Aberrant MALT1 activity is critical for NF-κB-dependent survival and proliferation of malignant cancer cells, which is fostered by paracaspase-catalyzed inactivation of negative regulators of the canonical NF-κB pathway like A20, CYLD and RelB. " 06/01/2023 - "The paracaspase MALT1 has emerged as a key regulator of immune signaling, which also promotes tumor development by both cancer cell-intrinsic and -extrinsic mechanisms. " 06/01/2023 - "Function and targeting of MALT1 paracaspase in cancer."
2.	Marginal Zone B-Cell Lymphoma (MALT Lymphoma) 01/08/2015 - "Our studies reveal a novel paracaspase-mediated oncogenic gain-of-function mechanism in the pathogenesis of MALT lymphoma. " 07/05/2023 - "Mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1) can function as a paracaspase to cleave specified substrates and it is predicted to interact with Nrf2. " 01/01/2019 - "Following activation of CD4+ T cells, however, N4BP1 undergoes rapid cleavage at Arg 509 by the paracaspase named mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1). " 05/24/2016 - "Mucosa-associated-lymphoid-tissue lymphoma-translocation gene 1 (MALT1), a paracaspase and essential regulator for nuclear factor kB (NF-κB) activation, plays an important role in innate and adaptive immunity. " 12/27/2011 - "The mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase, a key component of the Carma1/Bcl10/MALT1 signalosome, is critical for NF-κB signaling in multiple contexts. "
3.	Lymphoma (Lymphomas) 08/25/2023 - "Thus, MALT1 paracaspase acts as a bifurcation point for enhancing transcriptional and post-transcriptional gene expression in malignant lymphomas. " 03/01/2015 - "The paracaspase mucosa-associated lymphoid tissue 1 (MALT1) has been widely recognized to play crucial role in lymphocyte activation, development and the generation of lymphomas through the modulation of innate and adaptive immune responses. " 01/22/2015 - "Activity-based probes for detection of active MALT1 paracaspase in immune cells and lymphomas." 12/15/2013 - "Molecular pathways: targeting MALT1 paracaspase activity in lymphoma." 12/01/2021 - "Germline pathogenic variants impairing the caspase recruitment domain family member 11 (CARD11)-B cell chronic lymphocytic leukemia/lymphoma 10 (BCL10)-MALT1 paracaspase (MALT1) (CBM) complex are associated with diverse human diseases including combined immunodeficiency (CID), atopy, and lymphoproliferation. "
4.	B-Cell Lymphoma (Lymphoma, B Cell) 10/01/2018 - "Specific covalent inhibition of MALT1 paracaspase suppresses B cell lymphoma growth." 12/01/2014 - "Targeting B-cell lymphomas with inhibitors of the MALT1 paracaspase." 11/03/2015 - "The paracaspase MALT1 cleaves and removes negative checkpoint proteins, amplifying lymphocyte responses in NF-κB activation and in B-cell lymphoma subtypes. " 01/01/2013 - "The mucosa-associated lymphoid tissue protein-1 (MALT1, also known as paracaspase) is a protease whose activity is essential for the activation of lymphocytes and the growth of cells derived from human diffuse large B-cell lymphomas of the activated B-cell subtype (ABC DLBCL). " 12/01/2014 - "The protease activity of the paracaspase Malt1 has recently gained interest as a drug target for immunomodulation and the treatment of diffuse large B-cell lymphomas. "
5.	Inflammation (Inflammations) 01/01/2018 - "A CARD10-Dependent Tonic Signalosome Activates MALT1 Paracaspase and Regulates IL-17/TNF-α-Driven Keratinocyte Inflammation." 04/15/2015 - "Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation." 11/20/2014 - "Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation." 02/01/2016 - "Human paracaspase 1 (PCASP1), better known as mucosa associated lymphoid tissue lymphoma translocation 1 (MALT1), plays a key role in immunity and inflammation by regulating gene expression in lymphocytes and other immune cell types. " 11/28/2023 - "Constitutive activation of the MALT1 paracaspase in conventional T cells of Malt1TBM/TBM (TRAF6 Binding Mutant = TBM) mice causes fatal inflammation and autoimmunity, but the involved targets and underlying molecular mechanisms are unknown. "

Related Drugs and Biologics

1.	Monoclonal Antibodies
2.	Proteins (Proteins, Gene)
3.	Peptide Hydrolases (Proteases)
4.	NF-kappa B (NF-kB)
5.	Antigen Receptors (Antigen Receptor)
6.	Transcription Factors (Transcription Factor)
7.	T-Cell Antigen Receptors (T-Cell Receptor)
8.	Guanylate Kinases
9.	Inhibitor of Apoptosis Proteins
10.	TNF Receptor-Associated Factor 6 (TRAF6)

Related Therapies and Procedures

1.	Therapeutics
2.	Immunomodulation